At first glance that pic didn't make me think Demolition Man, it made me think it arrives in the mail in a discreet unlabeled package.
More seriously though, what helped my wrist and hands was switching to a small Wacom for everything -- not just art, but everything I'd use a mouse for.
I fully moved over to vertical mice, and replace the teflon on all of them with glass skates, and it's made such a difference in the amount of stamina I have for computer tasks.
I know glass skates sound like a Gamer thing but if you have motor issues that make fine control more of a strain, they greatly reduce the friction to the point that you aren't tensing up your wrist for micro-movements anywhere near as often to avoid overshooting...
Otherwise: avoid the current logitech vertical mice options, their drivers turn on mouse acceleration (because it's assumed you would only use those products if you have really extreme motor issues I guess?) and they're deprecating the previous version of their software that doesn't do that.
bonus: get the same mouse in right-handed and left-handed variants so you can dual-wield vertical mouses (mice?)
the benefit to that is if you use your non-dominant hand for most tasks (such as clicking web links and navigating files) then you don't wear out your dominant hand for precise input :D
I have one of these and i do love it but for a while i kept doing a thing where i would reach for it and smack it off my desk because it was taller than i was used to
dead serious about how much better vertical mice are for your wrists though, good lord. the first time i tried it in less than a week i was feeling way less pain and stress in my wrist
The going from worry about long term damage to my wrist from computer to actually I feel normal in like a week made me a firm advocate for vertical mice a few years ago
Funny story - messed up my wrist marathoning Diablo 2 the weekend before 3 came out. Had to switch to vertical mice. 10 years later, messed up my thumb through excessive trackball use. Wore a special brace for a few months, and it fixed not only my thumb but my supposedly incurable wrist.
Alternatively, they got Trackball mice where you control the ball with your thumb! Been using those for work and it's actually very comfortable considering you're not moving your wrist at all!
i've always wanted to invest in one of these but I've gotten way too used to the convenience of my gaming mouse having 8 buttons. It surprises me there's still no mouse out there that tries to do the same but vertical
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More seriously though, what helped my wrist and hands was switching to a small Wacom for everything -- not just art, but everything I'd use a mouse for.
the benefit to that is if you use your non-dominant hand for most tasks (such as clicking web links and navigating files) then you don't wear out your dominant hand for precise input :D