How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 new studies, we trace #glioblastoma heterogeneity to a spatial cancer cell trajectory w. multimodal cell atlassing bit.ly/4mkrWgs & predict plasticity w. snRNA/ATAC+deep learning bit.ly/3FbI6Ic 🧵 - ThreadSky

bayraktarlab.bsky.social • 19 days ago

How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 new studies, we trace #glioblastoma heterogeneity to a spatial cancer cell trajectory w. multimodal cell atlassing https://bit.ly/4mkrWgs & predict plasticity w. snRNA/ATAC+deep learning https://bit.ly/3FbI6Ic 🧵

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mhaniffa.bsky.social•18 days ago

Awesome work 👏🏾👏🏾👏🏾

bayraktarlab.bsky.social•17 days ago

Thanks Muzz!

barakrotblat.bsky.social•17 days ago

congrats!👏👏

halloulab.bsky.social•17 days ago

Amazing work! Many congratulations Omer @bayraktarlab.bsky.social and to the whole team 👏😀!!

bayraktarlab.bsky.social•17 days ago

Thanks Adrien!

q9f.bsky.social•19 days ago

📌

christophertape.bsky.social•18 days ago

Epic work Omer + team 👏

bayraktarlab.bsky.social•18 days ago

Thanks Chris!

bayraktarlab.bsky.social•19 days ago

Over the past 3 years, we led a fantastic @wellcomeleap.bsky.social collaboration w. @oliverstegle.bsky.social, Behjati, Mall, Mair, @jamesbriscoe.bsky.social & @juliosaezrod.bsky.social labs. We created a massive multiomic atlas & new comp models to discover human GB biology https://www.gbmspace.org/

bayraktarlab.bsky.social•19 days ago

Glioblastoma (GB) is a rapidly fatal brain tumour. Within each GB tumour, cancer cells exist across diverse cellular states + can switch their states (i.e. plasticity) + are thought to make tumour subtypes….

bayraktarlab.bsky.social•19 days ago

BUT despite elegant work, we still don’t know how/why cancer cells diversify & transition across states. Do cancer cells follow a defined trajectory across tumours? Or is it a chaos of unrestrained plasticity? Treatments will continue to fail if we lack this basic understanding

bayraktarlab.bsky.social•19 days ago

In paper 1, we tackled this big question. We created the GBM-space, the most comprehensive atlas of human GB. It uniquely pairs single cell + spatial modalities to bridge the cell, tissue and genetic basis of GB. Led by the amazing team of Grant, Tannia, Fani & Olga

bayraktarlab.bsky.social•19 days ago

Integrating these modalities, we interpreted human GB biology from scratch. We mapped GB heterogeneity to a spatially-patterned trajectory of cancer cells in tissue, where they transition from developmental-like towards glial injury response & hypoxia states.

bayraktarlab.bsky.social•19 days ago

It started with single nuclei RNA-seq. Profiling >1 million cells, we saw within each tumour that cancer cells vary from developmental progenitor-like states (e.g.NPC/OPC) to those marked by gliosis (i.e. glial injury response) & hypoxia Yet, the spatial/tissue context was the key…

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