Biotech is discovering the awesome power of fractional factorial designs (or similar randomized designs) and I'm all for it. en.wikipedia.org/wiki/Fractio... www.nature.com/articles/s41... - ThreadSky

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ekernf01.bsky.social • 19 days ago

Biotech is discovering the awesome power of fractional factorial designs (or similar randomized designs) and I'm all for it.

https://en.wikipedia.org/wiki/Fractional_factorial_design

https://www.nature.com/articles/s41587-024-02403-z

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neurostats.org•8 days ago

It's not about fractional factorial designs exactly though compressed sensing did draw out connections to that, group testing etc.. from mid 20th century.

I suspect BROAD experimental design folks are calling a lot more things compressed sensing than might be the case though.

neurostats.org•8 days ago

It is primarily about sampling signals such that sparse additive/functional regression can recover the original signal. The key thing being the signal can be dense in ambient space as long as it can be sparsely represented in some other representation.

https://users.soe.ucsc.edu/~afletcher/EE293/Week1Readings/Papers_Week1_and_Week2/Baraniuk_SPMag2007.pdf

neurostats.org•8 days ago

This has been directly used in designing experiments to learn fitness landscapes in protein design. But it's possible that others invoke 'CS' branding even if it is just regular regression doing the signal estimation.

neurostats.org•8 days ago

CS is about making something like FFD work in high dimensions and where the sparsity isn't obvious in the canonical basis/representation.

ekernf01.bsky.social•8 days ago

I admit I don't know compressed sensing. But you're right, there is a difference between the factorial design community testing a small number of factors and worrying about interactions versus the compressed sensing community testing way more and worrying about too many main effects.

neurostats.org•8 days ago

The math for why it works is definitely related for both to answe 'how many measurements do you need to make for this to work?' But they might merely be reinventing that here. But also I totally agree that fractional designs are underutilized in bio experiments.

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