As an engineer at heart, I wondered how we would scale up if we found a non-toxic, bioactive analogue. That led us to 𝗯𝗶𝗼𝗰𝗮𝘁𝗮𝗹𝘆𝘀𝗶𝘀 (think immobilised enzymes) - screening lipases and esterases to reach, in 1 step, a key intermediate: Taginitol C. This work was patented.
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Europe PMC https://europepmc.org/article/PAT/FR2941697
Google Patents
https://patents.google.com/patent/FR2941697A1/en