Published today in Nature Medicine. In one of the world’s largest RCTs of its kind (n=3,936), a smartphone app teaching 5 key cognitive-behavioral therapy skills improved subthreshold depression—and the effects lasted 6 months. www.nature.com/articles/s41... - ThreadSky

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toshi-frkw.bsky.social • 38 days ago

Published today in Nature Medicine. In one of the world’s largest RCTs of its kind (n=3,936), a smartphone app teaching 5 key cognitive-behavioral therapy skills improved subthreshold depression—and the effects lasted 6 months.

https://www.nature.com/articles/s41591-025-03639-1

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toshi-frkw.bsky.social•38 days ago

All five skills of behavioral activation, cognitive restructuring, problem solving, assertion training and behavior therapy for insomnia worked differentially for depression (primary outcome), anxiety, insomnia and well-being. The follow-up rate was 97% at week 6 and adherence to the app was 84%.

toshi-frkw.bsky.social•38 days ago

The master protocol design, involving four 2x2 factorial trials, and the digital platform contributed to the successful completion of this RESiLIENT trial. Scalable. Affordable. Global. @wlutzpsyres.bsky.social @pimcuijpers.bsky.social @alexiswhitton.bsky.social @masasakata.bsky.social

joarhalvorsen.bsky.social•38 days ago

Just read the protocol of the trial the other day (to learn more about adaptive platform trials). Congratulations on an impressive trial!

pablorom.bsky.social•37 days ago

📌

louisemewton.bsky.social•37 days ago

Wow, fantastic work! How on earth did you get those follow up rates in an online trial? I'll have to read the paper.

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