Really nice results from the Olsen group, evaluating the pre-accumulation method, which multiplies Orbitrap duty cycle at short transients and allows >70 Hz repetition rates.
They then combined it with PhiSDM spectral processing, mitigating the resolution sacrifice.
https://www.biorxiv.org/content/10.1101/2025.02.20.639277v1
They then combined it with PhiSDM spectral processing, mitigating the resolution sacrifice.
https://www.biorxiv.org/content/10.1101/2025.02.20.639277v1
Comments
I believe it makes a good case for the potential of the technique though.
Perhaps easier with new hardware.
Recall the paper on full mass range phiSDM on GPUs from Mann lab last year. Looks like the field is embracing monster computers for acquisition as well.
The Stellar parallelisation is similar to our original plan for the Astral ion processor, before we added the extra IRM trapping stage.