We discovered that in addition to its well known role in delaying the cell cycle as part of the spindle checkpoint, Mad3, has a separate role in promoting chromosome alignment on the spindle in budding yeast meiosis.
Comments
Log in with your Bluesky account to leave a comment
We found that Mad3 binds the Stu1 (CLASP) microtubule regulator through its degenerate TOGL1 domain. We showed that Mad3-Stu1 association rescues the segregation of chromosomes that lack crossovers or fail to biorient in meiosis I.
Comments