We tested for the first time whether such an arrangement is common for analogs in cosmological simulations (TNG & EAGLE). Turns out that no, the observed system is highly unexpected. At a level of 0.3%! Even considering the look-elsewhere effect (that analogs might be weird in some other sense).
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Of course we have also prepared a press release: https://www.aip.de/news/andromedas-asymmetrical-challenge-cosmology
And feel free to contact me if you have any questions!