So, either M31 is an extreme outlier to cosmological expectations, or an outright challenge to the cold dark matter model of cosmology. What speaks for the latter is that the unexpected lopsidedness is on top of the existence of a plane of satellites around M31, which already challenges the model.
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Of course we have also prepared a press release: https://www.aip.de/news/andromedas-asymmetrical-challenge-cosmology
And feel free to contact me if you have any questions!