Another nice study illustrating that targeting responses to the nasal mucosa could be superior to systemic administration. The CAF09b adjuvant plus recombinant protein in an i.n. vaccine induced better nasal IgA and CD8 responses than i.m. mRNA.
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In vivo challenge after vaccination also showed strong protection for the i.n. administered vaccine, although protection wasn’t compared to the i.m. vaccine. Further evidence for targeting the local mucosa to facilitate protective immunity.
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