A network medicine approach to investigating #ME/CFS pathogenesis in severely ill patients: a pilot study www.frontiersin.org/journals/hum... Ron W. Davis & Wenzhong Xiao @openmedf.bsky.social - ThreadSky

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valebodi.bsky.social • 54 days ago

A network medicine approach to investigating #ME/CFS pathogenesis in severely ill patients: a pilot study https://www.frontiersin.org/journals/human-neuroscience/articles/10.3389/fnhum.2025.1509346/full Ron W. Davis & Wenzhong Xiao @openmedf.bsky.social

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onaalbizu.bsky.social•53 days ago

Individuals met the International Consensus Criteria for ME/CFS (ME-ICC)

valebodi.bsky.social•54 days ago

This pilot study harnessed the power of network medicine to unravel the complex pathogenesis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). By utilizing a network analysis on whole genome sequencing (WGS) data from the Severely Ill Patient Study (SIPS), we identified ME/CFS-

valebodi.bsky.social•54 days ago

associated proteins and delineated the corresponding network-level module, termed the SIPS disease module, together with its relevant pathways. This module demonstrated significant overlap with genes implicated in fatigue, cognitive disorders, and neurodegenerative diseases. Our pathway analysis

valebodi.bsky.social•54 days ago

revealed potential associations between ME/CFS and conditions such as COVID-19, Epstein–Barr virus (EBV) infection, neurodegenerative diseases, and pathways involved in cortisol synthesis and secretion, supporting the hypothesis that ME/CFS is a neuroimmune disorder. Additionally, our findings

valebodi.bsky.social•54 days ago

underscore a potential link between ME/CFS and estrogen signaling pathways, which may elucidate the higher prevalence of ME/CFS in females. These findings provide insights into the pathogenesis of ME/CFS from a network medicine perspective and highlight potential therapeutic targets.

valebodi.bsky.social•54 days ago

Further research is needed to validate these findings and explore their implications for improving diagnosis and treatment.

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