“NIH researchers found that exercise triggers mitochondrial DNA release in muscle, activating immune pathways that boost fat-burning fibers and fight obesity—but this same response may worsen fatigue in long COVID and #ME/CFS through immune overactivation.” www.cell.com/trends/endoc... - ThreadSky

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valebodi.bsky.social • 5 days ago

“NIH researchers found that exercise triggers mitochondrial DNA release in muscle, activating immune pathways that boost fat-burning fibers and fight obesity—but this same response may worsen fatigue in long COVID and #ME/CFS through immune overactivation.” https://www.cell.com/trends/endocrinology-metabolism/abstract/S1043-2760(25)00119-5

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valebodi.bsky.social•5 days ago

“Although the effect of exercise on health is generally beneficial, individual responses to physical activity may be different depending on their pre-existing condition. Fatigue and immune aberrancies are characteristics of patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS),

valebodi.bsky.social•5 days ago

a well-studied disorder estimated to affect up to 1% of the population and now may be even more prevalent as it has been likened to long COVID [17,18]. A recommendation for individuals with fatigue may be to improve fitness by exercise training, but clinical experience for patients with #ME/CFS

valebodi.bsky.social•5 days ago

suggests otherwise [19]. Individuals with ME/CFS, and possibly those with long COVID, can experience post-exertional malaise (PEM), a debilitating exacerbation of fatigue symptoms following minimal physical or cognitive exertion [20]. While the mechanism of this phenomenon remains unclear,

valebodi.bsky.social•5 days ago

mitochondrial dysfunction and dysregulated immune activation have been suggested to contribute to this deleterious response to exercise (21-23]. Such subgroups of patients highlight the importance of targeted prescription of physical activity.

landseasky.bsky.social•1 day ago

Fascinating. That fits how awful it feels to have post-exertional malaise with dysautonomia/POTS. It makes me wonder what is helpful about the targeted physical therapy for post-viral dysautonomia vs general exercise recommendations, insofar as the mitochondrial DNA release aspect.

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