Let's talk about a party—where drugs don't hit the dance floor but finely tune #EpithelialMechanics by hitting actomyosin cortex! 🧬💊 Here's our guide to doing drugs 🧵 - ThreadSky

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epimechfc.bsky.social • 3 days ago

Let's talk about a party—where drugs don't hit the dance floor but finely tune #EpithelialMechanics by hitting actomyosin cortex! 🧬💊
Here's our guide to doing drugs 🧵

Comments

epimechfc.bsky.social•3 days ago

If you like this poster, you can download it from here:
https://github.com/nchahare/epimechfc/blob/main/epimech.pdf

epimechfc.bsky.social•3 days ago

With drugs you can understand morphogenesis: @MorphoLab_AS_AR et. al. described the role of contractlity in follicle patterning in avian skin using drugs like blebbistatin and Calyculin.

epimechfc.bsky.social•3 days ago

or learn general physics of tissues: @xaviertrepat.bsky.social lab showed a novel phenomenon of active wetting/dewetting using drugs like blebbistatin and Y27632

epimechfc.bsky.social•3 days ago

or do rheology of the tissues and connect it to molecular scale:
@gcharras.bsky.social lab performed stress relaxation experiments in combination with drugs. For interfering with specific crosslinkers, they used shRNA.

epimechfc.bsky.social•3 days ago

The poster above is a simplification. The regulation of actomyosin cortex involves many moving parts. For details check out this latest review by @sshekhr lab

epimechfc.bsky.social•3 days ago

It can get even more complicated because there's cytoskeletal crosstalk. Read this classical review about Rho GTPases in cell biology by Etienne-Manneville and Hall.

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