Multiple types of condensates coexist within one nucleus, potentially interacting mechanically through modulating the chromatin network– we found that wetting condensates bundle and stiffen chromatin, constraining the size of non-wetting condensates.
Comments
Surface tension and stiffness– not just binding affinity or location– shape genome structure.
Elastocapillarity offers a physical basis for mesoscale nuclear morphology, with implications for gene regulation and disease.