Recently presented our work on how spatial transcriptomics + genetics can reveal putative causal tissue structures for complex traits.
📄 Preprint: https://doi.org/10.1101/2025.05.02.651876
#spatialbiology #genomics #genetics @lifesciences-ge.bsky.social
📄 Preprint: https://doi.org/10.1101/2025.05.02.651876
#spatialbiology #genomics #genetics @lifesciences-ge.bsky.social
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🧰 Our tool: the upcoming R package STEAM.
• 8 organs
• 31 spatial datasets
• 32 human diseases
• 152 trait-tissue pairs
• 2 brain sc/snRNA-seq datasets
💡 We used @opentargets.org for curated gene lists with genetic associations.
🔄 These two structures are known to engage in crosstalk: damage to one can affect the other.