Low-dose Rapamycin trial in PCS
RAP is mTOR inhibitor at high dose, immunomodulatory effect at low doses. Effects in viral activation, reverses immunosenescence, stabilices inflamatory cytokines.
Dose: single weekly dose of 1mg (2w)+ 2mg (2w)+ 4mg for 2 months
David Putrino
#MECFSConference2025
RAP is mTOR inhibitor at high dose, immunomodulatory effect at low doses. Effects in viral activation, reverses immunosenescence, stabilices inflamatory cytokines.
Dose: single weekly dose of 1mg (2w)+ 2mg (2w)+ 4mg for 2 months
David Putrino
#MECFSConference2025
Comments
Already 30 participants in.
Not acepted renal/hepatic dysfunction
The final idea is a COMBINATION THERAPIES APPROACH
This is a T cell dysfuntion. There is also B cell dysregulation. They are our reasonable targets.