i've also been doing a lot of reflecting on the 10 year anniversary of Drop-Seq! for example on the incredible exponential increase we've seen since then, from 1e4 cells to 1e8 cells in ten years, an unbelievable rate of progress! almost an order of magnitude every two years for tens years
tl;dr Huntington’s disease (and other neurodevelopmental diseases) chiefly arise from the accumulation of somatic repeat expansions in the genome, and the RNA and protein alterations come much later. As such Steven is optimistic for drug therapies that can stop the expansions before disease
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