We often talk about IFNa and IFNb interchangeably as type I IFNs but it's becoming more and more clear that they're not at all interchangeable, and that they may even have opposing functions. IFNb seems to be surprisingly toleragenic in certain contexts. @lozanzi.bsky.social
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Ivan Zanoni
#WeekendRead! #InterferonPower! Stunnenberg Pickkers Kox, Keramati &co show @natimmunol.bsky.org that 2 LPS injections in volunteers mimic the proinflammatory & immunosuppressive phases of #sepsis & found that IFNb treatment restores immune responsiveness in the suppressive phase!
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