Excited to share! @yeshapatel.bsky.social and I report...
Mutations in RNAP confer antibiotic resistance via transcriptome remodeling.
Repression of branched chain amino acid and Pyr pathways increases β-lactam resistance in B. subtilis.
#MicroSky #AMR #antibiotics
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00039-7
Mutations in RNAP confer antibiotic resistance via transcriptome remodeling.
Repression of branched chain amino acid and Pyr pathways increases β-lactam resistance in B. subtilis.
#MicroSky #AMR #antibiotics
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00039-7
Comments
Both BCAA (fatty acid synthesis) and CTP directly support membrane biogenesis.
#MicroSky #AMR #antibiotics
Consistently, we previously reported...
https://journals.asm.org/doi/10.1128/mbio.00475-23