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adamlmaclean.bsky.social
Assistant professor @USC. Modeling cell fate with dynamical systems & statistical inference. What makes a stem cell? macleanlab.usc.edu he/him
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next time I reply to a conceptually tricky reviewer 2 question, for which I have a less-than-perfect answer, I am sorely tempted to steal this line. "Having been weaned intellectually on these distinctions and others like them, I could scarcely be more aware of their import and force" - T.S. Kuhn

I'm stoked to submit my next paper to... Evolution <html_ent glyph="@amp;" ascii="&amp;"/> Development

Celebrate every win. Ideally with beer. Congratulations to Anupam. His first postdoc paper out of the lab was accepted today. Coming soon..…

Thanks to everyone who attended #SysBioSC2025. There's nothing quite like gathering people together in a room to dig deep into fascinating science and learn new things. Big 🙏 to the NSF-Simons Center at UCI who made it possible. (emerging into the CA sun sure helps too) #SingleCell #Genomics

New article is out! Sleep deprivation is bad for the brain transcriptome, but how quickly can a little sleep reverse this effect? A team effort and fun collaboration with @stephaniehicks.bsky.social (a thread) pubmed.ncbi.nlm.nih.gov/40315180/

I wrote about how we must stand and fight against the threat of eugenics. Fueled by white nationalism and scientific racism, these beliefs are factually wrong and ethically abhorrent. This fight includes supporting efforts to diversify our workforce & science. To stop now would be a deep betrayal.

I'm excited to announce that we have been able to reduce the registration fee for last-minute applicants to $30 due to funding climate uncertainty. Deadline: 4/30 **Systems Biology of Single Cells** 2025, May 8-9, 2025 at UC Irvine, don't miss out 😎 cellfate.uci.edu/2025sysbiosc/

Out now! Modeling the dynamics of EMT reveals genes associated with pan-cancer intermediate states and plasticity #SingleCell #Genomics #MathOnco www.nature.com/articles/s41...

TWO days left to register and submit your abstracts to **Systems Biology of Single Cells** 2025, taking place May 8-9, 2025 @UCIrvine don't miss out 😎 cellfate.uci.edu/2025sysbiosc/

I know there's like, some stuff going on in the world, but it really concerns me how we aren't talking more about the truly insidious, hideous nature of Aptos. Wow, if you thought Calibri could hurt...

Another satisfied Reviewer #2...

Inspired by @sciencehomecoming.bsky.social and ahead of the #StandUpforScience2025 March 7, I wrote a piece for the Bonner County Daily Bee on impact science funding has on daily lives and opportunities of rural Idahoans (and beyond) >> Text in 🧵 🧪 🏠 bonnercountydailybee.com/news/2025/ma... 1/n

#SingleCell #Genomics #MLsky #StatsSky

🌟 Systems Biology of Single Cells 🌟 at UC Irvine, May 8-9, 2025 Submit your abstracts for contributed talks or posters today! - developing theories of cell state dynamics? - integrating multiomic and spatial data at atlas scale? - engineering cells for therapeutics? ...and much much more

Lol this sign "Do not bring food into the library Food residue will attract mice Mice will acquire knowledge in the library Get into university Then replace you" 😂

Thanks to everyone for a fantastic meeting #SACB2025 @cancersysbio.bsky.social (I sure needed an injection of great science in *these times*) @mathcancer.bsky.social closing out the show...

The immunology session at #SACB2025 continues with @adamlmaclean.bsky.social discussing cell-cell interactions in tumor metastasis

My 'Nobel Prize' @mcgill.ca Physics Colloquium is available ! So ... Is Machine Learning Physics ? I explore Hopfield's work, how it relates to Spin glasses and how you can derive RBM. You'll also hear about the Netflix problem and Pavlov's dog experiments :). www.physics.mcgill.ca/seminars/onl...

Applications for this "Black Leaders in Cancer" #PhD studentship with our lab @icrlondon.bsky.social close on Thursday... if you know of someone who might be interested please do pass the link on.

This absolutely breaks my heart. The NINDS diversity team is top notch and their support has been instrumental for the career of many scientists.

"...applications of model discovery in biology are among the most exciting, precipitated by the astounding quantities of biological data and the extent to which we do not know the structure of most biological networks; there is a lot to learn." #SingleCell #MLsky journals.plos.org/ploscompbiol...

There's plenty left wanting in scientific publishing and yes, great change is sorely needed. But! is there anything so egregious as... *(Author list continued on next page)*

Why aren't we this honest in (most) modern scientific writing?

Yes, they can hallucinate papers that don't exist, discuss results that seem to be imaginary, and can be confusing and inconsistent. But talking to tenured professors may still be helpful

COMING SOON... 👀

A bit later than usual but, going over last year's posts, I found three themes even when, in my mind, most of the posts are authors giving their recent publications a different spin, turns out that there is a bit more diversity than I remember

Transapocalyptic ride to school...

but what happened to said uncrowded industry? did anyone discover its carrying capacity?

Happy new year! may you live this year as boldly as PNAS did its font color choices in 2014.

The incredible life story of Jewel Plummer Cobb, told by my inimitable colleague & friend @staceyfinley.bsky.social www.sciencedirect.com/science/arti...

Is there such a thing as good eggnog?

Reading a Scientific American article from 1976 and tbh the ads are as interesting as the science

Transition paths across the EMT landscape are dictated by network logic. A 🧵 on the perils of ignoring logic in ODE models of gene regulatory networks (GRNs) 🌟 also read on if you like: EMT, bifurcations, multistability, or Waddington-esque landscapes www.biorxiv.org/content/10.1...

Really don't think we needed another existential threat to humanity this year.

The 2025 SMB Annual Meeting is now accepting proposals for minisymposia, which are due January 16, 2025. Minisymposia can have up to three co-organizers and up to eight speakers. 2025.smb.org/submit #SMB2025 🧪

Super-awkward for the US justice system to have a case where the defendant AND victim were both rich white guys because now they have to actually go through the whole process.

Here is a #math #poetry competition for students: www.ams.org/learning-car... Deadline is February 2, 2025. Please spread wide and far!