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alexr.bsky.social
personalized cancer immunotherapy = genomics + immunology + machine learning + oncology (pirl.unc.edu)
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Where can I find a digitized form of the Byblos syllabary?

submitted 11 hours ago • 0 comments

The only uses for AI that have really stuck for me are: (1) generating Python plotting code with Claude & o3 (2) literature search and research brainstorming with ChatGPT Deep Research / o3 & Future House tools Both extremely high value! (Broader vibe coding usually a time sink)

submitted 1 day ago • 2 comments

I really don't agree. I really think that hoping that a space not filled with Nazis would have a nicer community vibe rather than being abusive and abrasive is not, I dunno, some kinda failing, it's a good thing to want and to strive towards. We spend our time here, why not want it to be pleasant?

submitted 1 day ago • 6 comments

As mass firings decimate US federal agencies, what does it mean for the FDA to phase out animal testing requirements? My latest for The Scientist.

submitted 4 days ago • 2 comments

It’s time: @benjamingvincent.bsky.social and I are going to do a cancer immunotherapy / cool research / accelerating future medicine podcast. Any tips for getting started?

submitted 10 days ago • 1 comment

I think this poster at AACR may have flown under the radar, but Tempus has a great dataset for (mostly) unbiased estimation of prevalence of rare fusion driven cancers and for NUT carcinoma they found that ~2/3 of cases are misdiagnosed: aacrjournals.org/cancerres/ar...

submitted 11 days ago • 0 comments

Friday futureposting: “concierge” medicine is surprisingly low in ambition, it’s still rare to develop a new therapy even with nearly unlimited resources. As we sink deeper into techno-oligarchy, motivated patronage will let us speedrun glacial therapeutic development timelines.

submitted 11 days ago • 1 comment

We're still waiting for another round of experiments to fully resolve this but here are some preliminary results: {mRNA, peptide + CpG} >>> {peptide + polyIC, peptide + montanide} STING agonist does not significantly enhance CpG Upcoming data with poly-ICLC +/- montanide

submitted 11 days ago • 3 comments

Riff Cohen great for playing “guess the language” with my kids (Is she playing any shows in France this summer?)

submitted 11 days ago • 0 comments

Our pre-print on investigating variation in South Asian genomes is now out! Thank you to @mikeschatz.bsky.social, @rajivmccoy.bsky.social and @aabiddanda.bsky.social for all their work on this. 🧵 A thread on the key results and takeaways from our work:

submitted 12 days ago • 2 comments

x-posting things here and comparing with X (x.com/iskander/sta...), Quality is pretty good on bsky but wish the quantity was 10x+ higher How do I get the responses/engagement up on these kinds of technical idealism threads?

submitted 12 days ago • 0 comments

IV administered mRNA encoding of bispecific antibodies with LNP targeting for liver expression: pmc.ncbi.nlm.nih.gov/articles/PMC...

submitted 12 days ago • 1 comment

Is there a consolidated calendar of international klezmer festivals?

submitted 12 days ago • 0 comments

@azforeman.bsky.social what do you think of Pimsleur?

submitted 12 days ago • 0 comments

Besides 2A linkers and IRES’s, what else do viruses use to break apart polyproteins?

submitted 13 days ago • 2 comments

Let’s dream a bit. How would you dramatically reorg biotech research / drug development to make dramatically faster progress towards curative therapies? (Don’t say “use AI”, hypothesis/candidate generation under current structure isn’t a bottleneck)

submitted 14 days ago • 4 comments

Do non-presenting MHC-like molecules evolve from classical MHC or vice versa? My guess is that since they’re often closer to MHC-I, which derives from MHC-II, that molecules like MICA are an evolved loss of binding groove / TCR reactivity. Does that make sense?

submitted 15 days ago • 0 comments

Has anyone made oral vaccines by engineering antigens into saponin expressing plants?

submitted 17 days ago • 0 comments

I’ve gotten so much deeper into T-cell culture, TCR sequencing, single chain trimers, TCR-T generation, &c than I ever expected to a few years ago. Now getting into TCR bispecifics, all this stuff is great. TODO: look at more TCRs in PDB, get better at using structure prediction

submitted 20 days ago • 1 comment

Is there a children’s book of collective nouns? (Just learned it’s a “roll of armadillos”)

submitted 20 days ago • 0 comments