alphafold.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Demis Hassabis this April: AlphaFold is helping to bring the end of all disease "within reach, maybe within a decade or so." I doubt there is a single drug developer who thinks this. Seems a bit irresponsible to me.

submitted 9 days ago • 18 comments

@visscherlab.bsky.social was once a nerdy kid from Alabama. Thanks to great public schools & NIH funding, she grew up to fight Alzheimer’s & restore sight. This is what American science makes possible. When we fight for science, we fight for each other. ❤️ #StandUpForScience zurl.co/qRS11

submitted 10 days ago • 0 comments

Have you ever been frustrated by how hard it is to tinker with AlphaFold 3? Here's a (hopefully) simple repo to instal locally on laptop/single-GPU and a handy notebook to play around with! github.com/chaitjo/alph...

submitted 13 days ago • 1 comment

Stand for Science! 📢

submitted 11 days ago • 1 comment

Must read. Shattered Science: The Scientific Research Lost Amid the Trump Administration’s NIH Cuts @anniewaldman.bsky.social @asiafields.bsky.social @ashleyclarkejourno.bsky.social

submitted 14 days ago • 9 comments

InterPro just got one of its biggest updates ever. Now with 1.8 billion AI-driven protein annotations, AlphaFold-based TED domains, and viral proteins from the Big Fantastic Virus Database (BFVD). See it all at www.ebi.ac.uk/interpro 🖥️🧬 @interprodb.bsky.social

submitted 14 days ago • 0 comments

Despite huge protein databanks and the use of AI tools like AlphaFold, a new previously overlooked covalent bonding motif has been revealed. #ChemSky #BioSky

submitted 15 days ago • 1 comment

AlphaFold models can be better than homology models. www.sciencedirect.com/science/arti...

submitted 16 days ago • 0 comments

#alphafold 🙃🤣 X-ray structure of MED23 : 2018 AF2 : 2021 In this particular case (MED23), AF2 just accurately predicts what was already known experimentally 🫣 #justsaying

submitted 16 days ago • 1 comment

Unlocking life’s secrets, one molecule at a time! ✨ AlphaFold reveals protein shapes, revolutionizing our understanding of biology & disease. 🧬 #biotech Source: https://phys.org/news/2025-06-protein-affinity-role-ai-drug.html

submitted 16 days ago • 0 comments

Must watch to understand AlphaFold 3 youtu.be/XpIMuCeEtSk?...

submitted 17 days ago • 0 comments

New lab preprint - Delora Baptista tested AlphaFold 2 and 3 for the prediction of structures of host-pathogen interactions and then applied these to study convergence of binding and molecular mimicry in host-pathogen vs. host-host interactions. www.biorxiv.org/content/10.1...

submitted 17 days ago • 1 comment

#StarTalk We Solved the Protein Folding Problem… Now What? www.youtube.com/watch?v=hJ4L... Neil, Chuck & Gary O’Reilly learn about Nobel-prize-winning Alphafold, the protein folding problem, & how solving it could end disease with AI researcher & Chief AI Officer of Isomorphic Labs, Max Jaderberg.

submitted 17 days ago • 0 comments

DeepMind’s new AlphaFold upgrade maps protein structures in minutes—speeding up drug discovery. The future of biotech is quantum-fast! 💊🧬 #DeepMind

submitted 17 days ago • 0 comments

This may be true.

submitted 18 days ago • 0 comments

We cannot continue to live in fantasy land and think we’re going to just innovate, innovate, innovate and ignore the atrocities happening in our own cities; poverty, hunger, abuse, and so much more. We can innovate and care at the same time.

submitted 18 days ago • 0 comments

Boltz-2 now predicts molecular binding affinity at newfound speed and accuracy - and it's open source! The permissive MIT license allows commercial drug developers to apply proprietary data and offers an advance over the structure prediction capabilities of AlphaFold 3. tinyurl.com/37c96c6y

submitted 20 days ago • 1 comment

AI’s approval for breast cancer risk prediction marks a new era in precision medicine. Progress like this must always be matched with strong clinical oversight and ethical care. Where might your scanned data end up? Privacy is needed with progress. www.insideprecisionmedicine.com/topics/oncol...

submitted 23 days ago • 0 comments

Good night alphafold you're the only good LLM alphafold we love you alphafold

submitted 23 days ago • 0 comments

CEOs are lying to you about AI and telling you they aren’t concerned about the massive job loss that is too happen. Behind closed doors they’re confessing it will happen. They need you to build their models and agents before they let you go. This is why they are silent. Sound the alarm now. 🚨

submitted 26 days ago • 1 comment

Earlier this year, with Google DeepMind, we held the AlphaFold Education Summit to increase and strengthen global capacity through train-the-trainer sessions & the co-development of further #AlphaFold training. Now, we can share the free course materials with you: www.ebi.ac.uk/training/mat... 🧪🖥️🧬

submitted 28 days ago • 0 comments

Our paper on testing #Alphafold predictions and structural phylogenetics of a #photosystem subunit is now published in @pplplantarum.bsky.social. Work by @tomdongmin.bsky.social, with JW Murray & D Pretorius at Imperial. onlinelibrary.wiley.com/doi/full/10.... @qmulse.bsky.social @qmul.ac.uk 🌳

submitted 29 days ago • 0 comments

In our latest study we used alphafold 3 to predict the interaction between HKU5 virus spike protein and its receptor, ACE2. Using a 2021-based dataset, AF3 produced a new interface that has now been validated by other groups with cryoEM. What other new interactions can AF3 show us? rdcu.be/en7Dy

submitted 29 days ago • 0 comments

Excited to share that our EndoMap project is now out! A fun collaboration with Miguel Gonzalez-Lozano from the @harperlabhms.bsky.social. Explore our #AlphaFold structural interactome of #XLMS complexes in endosomes-> endomap.hms.harvard.edu and read about it here-> www.nature.com/articles/s41...

submitted 29 days ago • 0 comments

New work @harvard by Miguel Gonzalez-Lozano @harperlabhms.bsky.social & @ernstschmid.bsky.social in Johannes Walter lab charts structural interactome of endosomes. #XL-MS #Alphafold Funded by @asapresearch.parkinsonsroadmap.org & NIH. Science continues-despite attacks www.nature.com/articles/s41...

submitted 29 days ago • 0 comments

The war on science in the US is already having an effect on private sector research like AlphaFold. Bears repeating but the private sector builds on top of things created by academic research for the public good. This hurts everyone.

submitted 29 days ago • 2 comments

If technology corporations treat AI disruption as progress only, and ignore its consequences, they risk destabilizing the very societies that enable their success. Disruption without support is a recipe for collapse. In ignoring substantial job loss, ecologically everyone loses.

submitted 30 days ago • 0 comments

Great work highlighting how important it is to carry out experimental structure determination instead relying on AlphaFold predictions. #crystallography #structure #biology #chemistry www.nature.com/articles/s41...

submitted 32 days ago • 1 comment

I believe in science

submitted 33 days ago • 507 comments

AlphaFold predictions accelerate protein structure determination but require experimental validation. Many align with crystallographic maps, but discrepancies occur, highlighting the importance of confidence assessment & verification for accurate structural insights.

submitted 33 days ago • 0 comments

Looping around #structuralbiology #Alphafold #AI #sciencehumor #protein #scicomm

submitted 34 days ago • 0 comments

“AI is an Apex Predator” - Christopher Lafayette

submitted 32 days ago • 0 comments

⚕️ MedSky ⚕️ French AI model rivals Google’s AlphaFold in drug discovery France’s Sorbonne University and Qubit Pharmaceuticals, a Sorbonne spin-off, have announced the “world’s most powerful” AI model for molecular simulation in pharmaceutical chemistry.

submitted 36 days ago • 0 comments

Some salad news: The code (github.com/mjendrusch/salad) is now somewhat cleaned up and there is a Colab notebook for running a full salad -> ProteinMPNN -> AlphaFold2 pipeline to design proteins like those in the image: colab.research.google.com/github/mjend... More improvements coming soon!

submitted 36 days ago • 0 comments

AlphaFold und andere Proteinstruktur-Vorhersageprogramme halluzinieren manchmal wild drauf los. Xavier Robert et al. von der Université de Lyon programmierten mit FoldScript einen Web-Server, der solche "Halluzinationen" entlarvt … Andrea Pitzschke stellt ihn vor: www.laborjournal.de/editorials/3...

submitted 35 days ago • 0 comments

Exploring the Structural Diversity and Evolution of the D1 Subunit of Photosystem II Using AlphaFold and Foldtree onlinelibrary.wiley.com/doi/10.1111/...

submitted 35 days ago • 0 comments