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Structural Basis for Cas9-Directed Spacer Acquisition in Type II-A CRISPR-Cas Systems https://www.biorxiv.org/content/10.1101/2025.06.12.659315v1

submitted 16 hours ago • 0 comments

The mechanism of ribosomal recruitment during translation initiation on Type 2 IRESs https://www.biorxiv.org/content/10.1101/2025.06.11.659010v1

submitted 1 day ago • 0 comments

MITF maintains genome stability in non-melanocytic cell lineages and suppresses Hippo pathway signaling https://www.biorxiv.org/content/10.1101/2025.06.09.658599v1

submitted 1 day ago • 0 comments

Stalled translation on transcripts cleaved by RNase L activates signaling important for innate immunity https://www.biorxiv.org/content/10.1101/2025.06.10.658914v1

submitted 1 day ago • 0 comments

HSV-1 orchestrates host RAP80 ubiquitination by ICP0 and UL36USP to promote viral survival https://www.biorxiv.org/content/10.1101/2025.06.10.658793v1

submitted 1 day ago • 0 comments

DNA extracted from boiled archival fish bones yields high quality whole genome sequencing data https://www.biorxiv.org/content/10.1101/2025.06.10.658604v1

submitted 1 day ago • 0 comments

Structures reveal how the Cas1-2/3 integrase captures, delivers, and integrates foreign DNA into CRISPR loci https://www.biorxiv.org/content/10.1101/2025.06.10.658980v1

submitted 1 day ago • 0 comments

Recombinant Expression and Purification of Plasmodium Heme Detoxification Protein in E. coli: Challenges and Discoveries https://www.biorxiv.org/content/10.1101/2025.06.11.659033v1

submitted 1 day ago • 0 comments

DAPL1 deficiency impairs autophagy in retinal pigment epithelium to drive age-dependent retinal pathologies https://www.biorxiv.org/content/10.1101/2025.06.09.658638v1

submitted 1 day ago • 0 comments

Fibrillin-Related Proteins Control Calcium Homeostasis in Dystrophic Muscle Across Species https://www.biorxiv.org/content/10.1101/2025.06.09.658655v1

submitted 1 day ago • 0 comments

Defective plasticity in dermatomyositis patients muscle stem cells is associated with sustained intrinsic inflammatory signaling and disruption of the histone H3.3 chromatin loading pathway https://www.biorxiv.org/content/10.1101/2025.06.09.658580v1

submitted 1 day ago • 0 comments

Unlocking River Biofilm Microbial Diversity: A Comparative Analysis of Sequencing Technologies https://www.biorxiv.org/content/10.1101/2025.06.09.658576v1

submitted 1 day ago • 0 comments

MuRF1 partners with TRIM72 to impair insulin signalling in skeletal muscle cells https://www.biorxiv.org/content/10.1101/2025.06.08.658491v1

submitted 2 days ago • 0 comments

TrAEL-seq captures DNA replication dynamics in mammalian cells https://www.biorxiv.org/content/10.1101/2025.06.09.658559v1

submitted 2 days ago • 0 comments

APOBEC3A deaminase catalyzes site-specific editing of transfer RNAs https://www.biorxiv.org/content/10.1101/2025.06.10.658825v1

submitted 2 days ago • 0 comments

Exapted CRISPR-Cas12f homologs drive RNA-guided transcription https://www.biorxiv.org/content/10.1101/2025.06.10.658865v1

submitted 2 days ago • 0 comments

The unique molecular recognition features of Siglec-10: structural insights into sialoglycan and antibody interactions https://www.biorxiv.org/content/10.1101/2025.06.10.658867v1

submitted 2 days ago • 0 comments

A male-drive female-sterile system for the self-limited control of the malaria mosquito Anopheles gambiae https://www.biorxiv.org/content/10.1101/2025.06.10.658817v1

submitted 2 days ago • 0 comments

Loss of Ythdf3 causes Danon disease-like features https://www.biorxiv.org/content/10.1101/2025.06.10.658803v1

submitted 2 days ago • 0 comments

PARP1 and PARP2 are dispensable for DNA repair by microhomology-mediated end-joining during mitosis. https://www.biorxiv.org/content/10.1101/2025.06.09.658719v1

submitted 3 days ago • 0 comments

Loss of nephronophthisis-associated nephrocystin-1 impairs DNA damage repair in kidney organoids https://www.biorxiv.org/content/10.1101/2025.06.09.658557v1

submitted 3 days ago • 0 comments

DDX3X acts as a selective dual switch regulator of mRNA translation in acute ER stress https://www.biorxiv.org/content/10.1101/2025.06.08.658532v1

submitted 3 days ago • 0 comments

SARS-CoV-2 reshapes mA methylation in long non-coding RNAs of human lung cells https://www.biorxiv.org/content/10.1101/2025.06.08.658496v1

submitted 3 days ago • 0 comments

A Transient Increase in Cardiomyocyte Protein O-GlcNAcylation Enhances Susceptibility to Pressure Overload-Induced Cardiac Remodeling https://www.biorxiv.org/content/10.1101/2025.06.04.657956v1

submitted 4 days ago • 0 comments

Metabolic tuning enables immediate adaptation to energy stress in yeast https://www.biorxiv.org/content/10.1101/2025.06.06.658098v1

submitted 4 days ago • 0 comments

Proteomic analysis of bronchoalveolar lavage fluid after lung transplantation associates stable allograft function with less lung damage at 12 months https://www.biorxiv.org/content/10.1101/2025.06.08.658472v1

submitted 4 days ago • 0 comments

Remodeling of tRNA modification in Trypanosoma cruzi life forms https://www.biorxiv.org/content/10.1101/2025.06.07.658256v1

submitted 4 days ago • 0 comments

RNA Dynamics Regulate Transcriptional Condensate Vivacity to Drive Gene Coordination https://www.biorxiv.org/content/10.1101/2025.06.06.658161v1

submitted 5 days ago • 0 comments

Minimal activation of the p53 DNA damage response by a modular cytosine base editor enables effective multiplexed gene knockout in induced pluripotent stem cells https://www.biorxiv.org/content/10.1101/2025.06.05.656583v1

submitted 5 days ago • 0 comments

Targeting Langerhans cells using a modular mannosylated nucleic acid-based vaccine platform https://www.biorxiv.org/content/10.1101/2025.06.04.657560v1

submitted 5 days ago • 0 comments

MRTF-dependent cytoskeletal dynamics drive efficient cell cycle progression https://www.biorxiv.org/content/10.1101/2025.06.06.657372v1

submitted 5 days ago • 0 comments

H3K4me1 directs H3K36me2 and H3K36me3 deposition in land plants https://www.biorxiv.org/content/10.1101/2025.06.06.658275v1

submitted 5 days ago • 0 comments

Competing 5' splice sites of SRC1/HEH1 are marked for alternative splicing by U5 and U6 snRNAs during the B to Bact transition of the spliceosome https://www.biorxiv.org/content/10.1101/2025.06.06.658024v1

submitted 5 days ago • 0 comments

Quantitative Assessment of Protein-DNA Interactions via SYBR Green Fluorescence https://www.biorxiv.org/content/10.1101/2025.06.06.658291v1

submitted 5 days ago • 0 comments

A novel Notch and WNT signaling mechanism contribute to pediatric DCM: a pathway to new therapeutics. https://www.biorxiv.org/content/10.1101/2025.06.07.658396v1

submitted 5 days ago • 0 comments

Regulation of essential hepatocyte functions and identity by super-enhancers in health and disease https://www.biorxiv.org/content/10.1101/2025.06.04.657826v1

submitted 5 days ago • 0 comments

The apoptosis gene BCL-X splice isoforms have opposing effects in diabetic kidney disease: potential treatment target and prognostic value https://www.biorxiv.org/content/10.1101/2025.06.06.658276v1

submitted 5 days ago • 0 comments

Advancing Ligand Binding Affinity Prediction with Cartesian Tensor-Based Deep Learning https://www.biorxiv.org/content/10.1101/2025.06.04.657800v1

submitted 5 days ago • 0 comments

Atypical features of the disordered N-terminal region of a bacterial outer membrane copper transporter. https://www.biorxiv.org/content/10.1101/2025.06.04.657848v1

submitted 6 days ago • 0 comments

Structures of EHD2 filaments on curved membranes provide a model for caveolar neck stabilization https://www.biorxiv.org/content/10.1101/2025.06.05.658037v1

submitted 6 days ago • 0 comments

Uncovering Host-Parasite Dynamics: Gene Expression Shifts in Hematodinium-infected Chionoecetes bairdi in Response to Temperature ... https://www.biorxiv.org/content/10.1101/2025.06.05.658092v1

submitted 6 days ago • 0 comments

Negative epistasis limits current codon optimization approaches https://www.biorxiv.org/content/10.1101/2025.06.03.657573v1

submitted 6 days ago • 0 comments

Dynamic DnaA-DnaB interactions at oriC coordinate the loading and coupled translocation of two DnaB helicases for bidirectional replication https://www.biorxiv.org/content/10.1101/2025.06.05.657979v1

submitted 6 days ago • 0 comments

IL-18 inhibition enlarges lesions, necrotic cores and thickens fibrous caps in Jak2V617F clonal hematopoiesis-driven atherosclerosis. https://www.biorxiv.org/content/10.1101/2025.06.03.657754v1

submitted 6 days ago • 0 comments

Designing a broad-spectrum four-helix bundle targeting different strains of SARS-CoV-2 Spike Receptor Binding Domains with ACE2-like binding interface https://www.biorxiv.org/content/10.1101/2025.06.04.657798v1

submitted 6 days ago • 0 comments

The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome https://www.biorxiv.org/content/10.1101/2025.06.03.656903v1

submitted 6 days ago • 0 comments

Transcriptome-wide RNA accessibility mapping reveals structured RNA elements and pervasive conformational rearrangements under stress https://www.biorxiv.org/content/10.1101/2025.06.05.658101v1

submitted 7 days ago • 0 comments

RNA structure directs RNA partitioning and is actively disrupted inside stress granules to enable cellular recovery https://www.biorxiv.org/content/10.1101/2025.06.05.658090v1

submitted 7 days ago • 0 comments

SOX2 and SOX9 as Transcriptional Regulators of human Galectin-3 in SW1353 Cells: Potential Implications for Osteoarthritis https://www.biorxiv.org/content/10.1101/2025.06.03.657610v1

submitted 8 days ago • 0 comments

Dcaf17 knockdown integrates mitochondrial-lysosomal dysfunction with ferroptosis, NLRP3 inflammasome signaling and necroptosis https://www.biorxiv.org/content/10.1101/2025.06.04.657829v1

submitted 8 days ago • 0 comments