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cedricboeckx.bsky.social
Evolution, Genetics, Cognitive Science, Language
607 posts 1,864 followers 253 following
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Important new work from @nccrlanguage.bsky.social offering evidence for a special (social) Umwelt for human language acquisition 🧪👇

New work by @nccrlanguage.bsky.social members @franziswegdell.bsky.social @carolinefryns.bsky.social J. Schick @sabinestoll.bsky.social @zuberbuehler.bsky.social S. Townsend: The evolution of infant-directed communication: Comparing input across all great apes, revealing an important shift in us 🧪

One thing that makes humans remarkable is baby talk. And that might be one reason why we have language. Here's my story [Gift link] nyti.ms/4k5duXd

New work by @nccrlanguage.bsky.social members @franziswegdell.bsky.social @carolinefryns.bsky.social J. Schick @sabinestoll.bsky.social @zuberbuehler.bsky.social S. Townsend: The evolution of infant-directed communication: Comparing input across all great apes, revealing an important shift in us 🧪

“A global map for introgressed structural variation and selection in humans” New preprint by Evan Eichler, @ee-reh-neh.bsky.social and collaborators, identifying structural variants introgressed from other hominins & associated with adaptive signatures 🧪🧬

How do non-coding variants in enhancers lead to disease? Happy to share our recent work, led by @ewholling.bsky.social, in which we discovered that poised chromatin sensitizes enhancers to aberrant activation by non-coding mutations, contributing to disease. www.biorxiv.org/content/10.1... 1/

Very interesting @ecoevorxiv.bsky.social study by @sabinestoll.bsky.social @balthasarbickel.bsky.social & colleagues @nccrlanguage.bsky.social arguing that increased vocal accommodation (as a sign of homophily) facilitated the evolution of vocal production learning in the hominin lineage 🧪

Congrats @akanksha-jain.bsky.social @graycamplab.bsky.social & Treutlein lab on publishing this @nature.com study on early brain organoid development, with insights into processes underlying brain regionalization 🧪🧠🧬🧫 www.nature.com/articles/s41...

Re-reading the latest version of this preprint on H. longi/Denisovans by X. Ni @chrisbstringer.bsky.social and colleagues, in light of the two important Harbin skull studies led by Qiaomei Fu that came out this week 🧪💀🧬 www.biorxiv.org/content/10.1...

Terrific Wilkins-Bernal-Medawar Prize Lecture by @matthewcobb.bsky.social royalsociety.org/science-even... Only a few months left to finally get a copy of his forthcoming biography of F. Crick

A 3D view of apical radial glia finding their way in the developing human cortex. A stunning video shared by @gessicagoncalves.bsky.social who cultures organotypic cortical slices to study cell dynamics during human cortex development.

Morphodynamics of human early brain organoid development @nature.com @akanksha-jain.bsky.social @graycamplab.bsky.social nature.com/articles/s41...

My latest story is based on papers in @science.org and @cp-cell.bsky.social revealing Homo longi aka 'Dragon Man' was a Denisovan - or is it the other way around? Featuring @benceviola.bsky.social, @fridowelker.bsky.social and @chrisbstringer.bsky.social. www.nationalgeographic.com/history/arti...

Textbooks: “Enhancers are just a bunch of TFBSs” But how do they REALLY work? New paper with many contributors here @berkeleylab.lbl.gov, @anshulkundaje.bsky.social, @anusri.bsky.social A 🧵 (1/n) Free access link: rdcu.be/erD22

About 70,000 years ago, a new study suggests, our species learned to live just about anywhere. Later, that ability helped our ancestors expand from Africa across the world. Here’s my story on the human niche [Gift link] nyti.ms/3ZBc7ID

Dragon Man was a Denisovan! DNA and proteins both confirm it, giving this mysterious human lineage a face at long last. Here’s my story. [Gift link] nyti.ms/44nQq1i

1/5 Why do all non-Africans descended from a group that left Africa 50k ago? In @nature.com we model 120k years of human niche dynamics. From 70ka, a big expansion of the human niche in Africa likely equipped later OOA dispersals with a unique ecological flexibilty. www.nature.com/articles/s41...

Interesting Science Advances study probing the genetics of human brain geometry (beyond volume), using data from @ukbiobank.bsky.social 🧪🧠🧬

Powerful new method (Capture-C MPRA) to simultaneously characterize promoter interactions and regulatory activity. Preprint by @colinearnould.bsky.social @nadavahituv.bsky.social & collaborators 🧪🧬

Nice piece by @mehr.nz on the special(ized) character of human auditory perception underlying musicality; contains very good points re: cross-species (dis)analogies (e.g. why bird ‘song’ may be a misnomer) 🧪

Our paper on gene regulatory networks controlling hypothalamic and prethalamic development is now out in Cell Reports./1 www.cell.com/cell-reports...

A look at the developing human embryonic forebrain in 3D! Post-doc @stochastalive.bsky.social shares this week's image showing a dorsal view of the human embryonic forebrain at Carnegie Stage 16 (~6 weeks post conception). Major regions marked by FOXG1, WNT8B, PAX6, and SHH are displayed.

How do brain circuits evolve? We started looking for some answers by using synapse-resolution cross-species comparative connectomics on an entire olfactory circuit 👇 bit.ly/44aVm9E

🔔 Proud to share the preprint of my PhD work in the Petridou group @nicolettapetridou.bsky.social @embl.org ✨ “A closed feedback between tissue phase transitions and morphogen gradients drives patterning dynamics” 🐟 🔁 📶 🔗 www.biorxiv.org/content/10.1... #devbio #biophysics 🧵⤵️

Our new work is now out in AJHG "Natural selection acting on complex traits hampers the predictive accuracy of polygenic scores in ancient samples." Great collaboration with @delvecchyo.bsky.social and Emilia Huerta-Sanchez, led by Valeria Añorve-Garibay.

Why do so many disease risk variants show no regulatory effects in GTEx and/or other standard eQTL studies? What do we mean when we say a regulatory effect is "context-specific" and how do we define the context? We explored these questions using brain organoids and oxygen stress.