charlesbj.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Excited to unveil Boltz-2, our new model capable not only of predicting structures but also binding affinities! Boltz-2 is the first AI model to approach the performance of FEP simulations while being more than 1000x faster! All open-sourced under MIT license! A thread… 🤗🚀

submitted 10 days ago • 10 comments

Delighted to announce the release of Boltz-2, which demonstrates unprecedented accuracy in predicting structure and binding affinity! Congrats to Sara Passaro, @gcorso.bsky.social + @jeremywohlwend.bsky.social on this stunning achievement! 📄Paper: bit.ly/boltz2-pdf 💻Code: github.com/jwohlwend/bo...

submitted 10 days ago • 1 comment

Monash just got a huge upgrade - How a $60m computer called MAVERIC could change Australia’s AI future www.afr.com/technology/h...

submitted 11 days ago • 0 comments

First day in the UK (after 10 odd years). Greggs is an instant favourite 👏. Instant anti-favourite is £3.9 for a coffee, oddly has the same effect as drinking a coffee, except that you walk away looking like deer in headlights.

submitted 16 days ago • 1 comment

Australia should pay attention to what Trump did to Harvard. Excellent piece from the VC of the University of Sydney. It would be very popular for Labor to heavily invest in Uni Ed and Science (opposite Trump). Support international students and scientists. www.sydney.edu.au/news-opinion...

submitted 20 days ago • 0 comments

International students, as well as our brilliant domestic students, are the bedrock of our research and innovation sector. They're valuable beyond words. We should welcome them arms wide open.

submitted 20 days ago • 0 comments

New study of calcitonin and amylin receptors bound to cagrilintide out of the labs of Denise Wootten & Patrick Sexton. Work driven by Jason Cao, @bluesocks81.bsky.social, and Rachel Johnson, et al. @ccemmp-outreach.bsky.social Happy to have been involved 🎉 www.nature.com/articles/s41...

submitted 66 days ago • 0 comments

Excited to share that our work on a family of pore-forming proteins is now live in Science Advances! We show structural snapshots across the entire pore-forming pathway for a cholesterol-dependent cytolysin-like (CDCL) bicomponent system.

submitted 78 days ago • 3 comments

Teeny tiny by day, bigly by night...

submitted 95 days ago • 0 comments

Saved a bee. 😎 That's the post.

submitted 96 days ago • 0 comments

Sigh... the "protein folding problem" ≠ "structure predicition".

submitted 99 days ago • 3 comments

Hot days (and grid atlases) are for a cold knock off beer... 🍻

submitted 110 days ago • 0 comments

Injecting arbitrary experimental data into AlphaFold has been a missing feature. With high-throughput crystallography yielding 1000s of structures/year (@covid_moonshot) & cryoET making 😍 but low-res in situ models, it's also become a necessary one for scaling up structural biology. Hence ROCKET👇!

submitted 112 days ago • 2 comments

I've decided to start posting more mundane stuff to try and dilute some of the doom scrolling. Enjoying a bruschetta snack, nice view, and cucumber and yuzu G&T. Cheers.

submitted 112 days ago • 2 comments

Do you like the beaches hot and your electron microscopy cold? 👇

submitted 117 days ago • 0 comments

Very happy to share our protocol for pair correlation microscopy of intracellular molecular transport. Congratulations @julissasv.bsky.social and thanks to Enrico, @digmanlab.bsky.social, Francesco, Ash! www.nature.com/articles/s41...

submitted 128 days ago • 0 comments

I am very happy to share our latest work on the detailed cryo-EM structure of the NDH-PSI supercomplex of spinach. Thanks to Werner Kühlbrandt, Alex Hahn and @mpibp.bsky.social ! 🍃❄️🔬 You can find the paper in open access in Nature Structural and Molecular Biology: www.nature.com/articles/s41...

submitted 140 days ago • 4 comments

🚨 Save the Date! 🚨 I'm thrilled to announce the Prato Conference on Pore Forming Proteins, happening this June in the stunning city of Prato, Italy! 🙏 Please share or repost this to help us reach as many people as possible—especially those who would love to attend!

submitted 151 days ago • 2 comments

"PhD enrollments decline in Australia as economic pressures discourage prospective students." Nearly three-quarters of University of Melbourne graduate students said food security was their top concern.

submitted 151 days ago • 1 comment

@dtegunov.bsky.social @dabiophysicist.bsky.social ... just casually following your discussion and this popped up. Worth testing for tilt series alignment? zju3dv.github.io/MatchAnything/

submitted 153 days ago • 1 comment

👋 #teamtomo Has anyone managed to compile stopgap from src? I'm a noob at MATLAB... Trying to debug and troubleshoot, but can't recompile edited code, so not making much progress 😅... #cryoET #cryoEM

submitted 159 days ago • 0 comments

Bier, Brot, und Wurst. 😍 Prost! Happy holidays.

submitted 167 days ago • 1 comment

How proximal is proximity labeling❓ Using DNA nanorulers we found that TurboID/BioID are largely contact labeling, while APEX2 also bears a major contact labeling pathway in parallel with diffusive labeling. www.biorxiv.org/content/10.1... Special thanks to @aliceyting.bsky.social for discussions

submitted 179 days ago • 2 comments

Unicore identifies single-copy protein structures across genomes using Foldseek, bypassing slow structure predictions by utilizing 3Di predictions from ProstT5, enabling rapid phylogenetic inference at the tree-of-life scale. 1/n 📄 www.biorxiv.org/content/10.1... 💾 github.com/steineggerla...

submitted 175 days ago • 2 comments

🎄 xmas preprint 🎄 we are excited to share our cryo-EM structure of UBR4 in complex with KCMF1 and CALM1. the PQC ligase forms a massive ubiquitination arena, primed to amplify ubiquitin chains (E4 activity) and boost degradation of defective proteins. www.biorxiv.org/content/10.1...

submitted 177 days ago • 4 comments

1/ Thrilled to announce Dr. Elizabeth Wright as the inaugural winner of the June Almeida Award for #cryoem! 🎉Elizabeth’s pioneering work in both cryo-ET methods and structural virology made her a perfect fit for this award. Congrats, Elizabeth!

submitted 181 days ago • 1 comment

👋 #skybrain, can anyone point me to useful resources for common non-canonical/non-natural amino acids? I'm looking for a collated summary of ncAA with descriptions of their uses/applications. I've exhausted google... #biochemistry #proteins

submitted 182 days ago • 2 comments

High-resolution template matching of the human ribosome in situ by Lippincott-Schwartz Lab @hhmijanelia.bsky.social @hhmi.bsky.social. >40 conformations within together reveal molecular dynamics of the elongation cycle with previously unknown bending and “spring-like” motion.

submitted 195 days ago • 1 comment

Putting all conference organisers on notice - this is how spaced posters should be... Think accessibility. But also, people actually need room to stand beside their poster and present it without inconveniencing their neighbouring colleagues.

submitted 187 days ago • 2 comments

Super excited to preprint our work on developing a Biomolecular Emulator (BioEmu): Scalable emulation of protein equilibrium ensembles with generative deep learning from @msftresearch.bsky.social ch AI for Science. www.biorxiv.org/content/10.1...

submitted 192 days ago • 22 comments

The PDBs for our TSC structure are now available! To put the size of TSC in perspective, here's a ribosome... this thing is enormous. 🤩 #cryoEM #mTORC1 #TSC rcsb.org/3d-view/9CE3 science.org/doi/10.1126/sciadv.adr5807 @luptoncj.bsky.social

submitted 191 days ago • 1 comment

Scalable emulation of protein equilibrium ensembles with generative deep learning www.biorxiv.org/content/10.1... No code is available yet, but sounds huge. Effectively does MD-sim, but fast!

submitted 192 days ago • 0 comments

We’ve had nearly 3 years of review, review, review. We need reviews, but it’s blindingly obvious that Australian research needs much greater Government investment while those reviews are done. This was true 3 years ago. Still true now. By @drjr.bsky.social

submitted 199 days ago • 3 comments

We’re excited to release a major update to the Boltz repo: v0.3.0. This release contains several important new features, including our confidence model and memory-efficient inference. Give it a try! github.com/jwohlwend/bo...

submitted 200 days ago • 2 comments