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chrislbgraham.bsky.social
Research Fellow at University of Warwick. Open Science, Proteins and Lipids.
17 posts 104 followers 260 following
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We have updated ConservFold. Now it can plot conservation onto whole protein complexes and can set the cutoffs you’d like! Thought it might be useful for people. colab.research.google.com/drive/1Lv-ak... @crodrigueslab.bsky.social

submitted 16 days ago • 0 comments

Beta-lactams covalently bind to Penicillin Binding Proteins and have been the mainstay of antimicrobial chemotherapy for decades. In this new paper with colleagues @Bicycle_tx we show a new way to hit old targets: rdcu.be/eoaRI

submitted 22 days ago • 0 comments

"Revolutionary"? More like reclaiming wisdom! 👏 French farmers & scientists prove nature-based farming (no #pesticides, no synthetics), the way humans farmed for centuries, still delivers steady yields, stable incomes & boosts biodiversity after 30 years. #ClimateAction f24.my/BCO5.BS

submitted 23 days ago • 1 comment

Another great collaboration where we studied the type IV SS of CPRs, which certainly opens new avenues for the study of these enigmatic (mostly epibiotic) organisms! @frvalera.bsky.social www.microbiologyresearch.org/content/jour...

submitted 24 days ago • 0 comments

AlphaFold’s success builds on decades of tech advances, massive efforts to collect, curate, and share structural data, and rigorous benchmarking. What will it take to see a similar leap in structural ensemble prediction? @stephanieaw.bsky.social and I share some thoughts here 👇 Feedback is welcome!

submitted 43 days ago • 1 comment

Just released a pre-print: www.biorxiv.org/content/10.1... We simulate lipid membrane toroids of bacteria, representing the point where one cell splits into two. We see they are stable and then look at how a key protein might behave at them @crodrigueslab.bsky.social @pstansfeld.bsky.social

submitted 47 days ago • 0 comments

Just released a pre-print: www.biorxiv.org/content/10.1... We simulate lipid membrane toroids of bacteria, representing the point where one cell splits into two. We see they are stable and then look at how a key protein might behave at them @crodrigueslab.bsky.social @pstansfeld.bsky.social

submitted 47 days ago • 0 comments

ChimeraX daily builds can predict small complexes of proteins, nucleic acids and small molecules using Boltz on your Mac, Windows or Linux computer without Nvidia graphics. www.rbvi.ucsf.edu/chimerax/dat...

submitted 49 days ago • 3 comments

Nature research paper: The distribution of subsurface microplastics in the ocean https://go.nature.com/4iHBBKS

submitted 50 days ago • 1 comment

A huge, new resource for plasmid research - PlasmidScope is a database of 852,000 #plasmid sequences with a rich set of annotations, automated online analysis and interactive visualisation academic.oup.com/nar/article/...

submitted 58 days ago • 4 comments

Introducing SAVEMONEY, AKA ‘Simple Algorithm for Very Efficient Multiplexing of Oxford Nanopore Experiments for You’ A new tool offering a faster, cheaper computational approach to democratise whole-plasmid sequencing. buff.ly/ov7YumB

submitted 66 days ago • 1 comment

Here our new preprint on the LPS holo-translocon doi.org/10.1101/2025... , collaboration with Yves Quentin @JulieMarcoux @fronzeslab.bsky.social @pstansfeld.bsky.social - @cbitoulouse.bsky.social

submitted 69 days ago • 1 comment

New preprint! FtsEX-EnvC is a Type VII ABC transporter that activates the periplasmic enzymes needed to break the peptidoglycan layer during cell division. We tested the importance of structural features underpinning activation and the auto-inhibition mechanism that keeps it all in check.

submitted 73 days ago • 0 comments

Enzymes found in landfills around the world may be able to break down plastic waste. By using metagenomics and machine learning, a global collection of plastic biocatalytic enzymes has been identified. Plastics may not be forever, anymore. In PNAS Nexus: academic.oup.com/pnasnexus/ar...

submitted 86 days ago • 4 comments

Two esteemed colleagues both declared to me to eat more fries and more wine if we need to live longer. It’s gonna be a great Tuesday! I also hope the cafeteria adds more fried foods to the menu www.nature.com/articles/s41...

submitted 86 days ago • 0 comments

London April 11th and 12th, I’m doing a tiny workshop (I’ll be there the Saturday) with my friend on how to do PCR on worms plastic poop. It could be interesting if anyone wants to teach anyone a bit of hands on science on a weekend. PCR: barcode bacterial DNA www.eventbrite.co.uk/e/pcr-barcod...

submitted 89 days ago • 0 comments

pubs.acs.org/doi/10.1021/... New paper from the lab! Thanks to Fabrizio Alberti and his lab for the great collaboration and to Michael Tadesse for all his hard work!! Thanks @warwicklifesci.bsky.social, MIBTP and BBSRC for funding!

submitted 93 days ago • 0 comments

Come to the opening of the Warwick Integrated Structural Biology Symposium! @uni-of-warwick.bsky.social @warwicklifesci.bsky.social

submitted 106 days ago • 0 comments

A really nice tool, like others that Artyom has produced. Highly recommend.

submitted 114 days ago • 0 comments

Join us at the next Science on the Hill event on Tuesday 25 February. We’ll delve into how different biological systems combat attacks from other organisms - highlighting the human and plant immune systems. Find out more and book your place bit.ly/435PAGo

submitted 118 days ago • 0 comments

come and join in !

submitted 120 days ago • 0 comments