cijilim.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

AND IT'S DONE! A 🧵 on our recent article now out in @natsmb.nature.com! Co-led with @abbybartlett.bsky.social, Pagliarini Lab, @judisimcox.bsky.social, we find ACAD10/11 are NOT like other acyl-CoA dehydrogenases and instead catabolize atypical lipids called 4-hydroxy acids 🤯 doi.org/10.1038/s415...

submitted 15 hours ago • 2 comments

Take #3... Happy to share our latest work from Ye Liu. Control of 3' Splice Site Selection in S. cerevisiae by a Highly Conserved Amino Acid within the Prp8 α-finger Domain Ye Liu, Joshua C Paulson, Aaron A Hoskins www.biorxiv.org/content/10.1...

submitted 7 hours ago • 2 comments

Postdoc positions open in my lab (Francis Crick Institute) to study 1. initiation of DNA replication. 2. chromatin replication/epigenetic inheritance. Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists. Deadline 3 August 2025. crick.wd3.myworkdayjobs.com/External/job...

submitted 3 days ago • 1 comment

www.kpbs.org/podcasts/kpb...

submitted 3 days ago • 0 comments

Great job opportunity at The Center for Integrative Genomics, Lausanne University, Switzerland unil.ch/cig/en/home.... For a tenure-track Assistant Professor position. More details for how to apply are here nature.com/naturecareer...

submitted 6 days ago • 0 comments

Check out our latest preprint with the Qi lab on the structure and disease physiology of the human ERAD complex. Outstanding work by Leo, a cell physiologist whom we successfully tempted into structural biology! Preprint: www.biorxiv.org/content/10.1...

submitted 7 days ago • 4 comments

Interested in a postdoc position combining computational protein design and molecular simulation? There is an open position in my group at the MRC-LMB in Cambridge, UK. www.nature.com/naturecareer... Feel free to message me with any questions.

submitted 7 days ago • 0 comments

Scientists looking to move to Canada 🇨🇦: @sfuscience.bsky.social has funding for some faculty positions for this. Deadline soon (june 30). www.sfu.ca/vpacademic/a...

submitted 7 days ago • 0 comments

📢 We are hiring for two new Faculty roles to join the ICR community. Learn more and apply today ⬇️🧵

submitted 7 days ago • 1 comment

The videos for the recent CCP4 Study Weekend 2025 are now available on YouTube. www.youtube.com/playlist?lis...

submitted 13 days ago • 0 comments

The amazing Sofia Lövestam initiated the below project, when she became interested in the vault particles that we sometimes observe in #cryoEM images of brain-derived #amyloid filaments. www.biorxiv.org/content/10.1...

submitted 26 days ago • 2 comments

If you are an established scientist interested in moving the UK, the Royal Society Faraday Fellowships can support this. royalsociety.org/news/2025/05... If you are interested in moving to University of Warwick School of Life Sciences via this fellowship, get in touch! #microsky #microscopy

submitted 11 days ago • 0 comments

Registration now open for the Midwest Enzyme Chemistry Conference 2025. Registration Link: lnkd.in/ggHMWrF5 Event Date: September 27, 2025 Location: University of Wisconsin - Milwaukee It's free to register Kindly share as we want to grow this amazing community of mechanistic enzymologists.....

submitted 25 days ago • 2 comments

A message from Carl Sagan from 1995—some of his last prophetic words.

submitted 12 days ago • 223 comments

Reminder: Nobel-prize winning PCR (1983), used in basically all genetic tech today, was only possible because of extremophile bacterium discovered in 1964 in Yellowstone funded by a small ~$80k NSF grant with no obvious application at the time. #science 🧪 www.richmondscientific.com/how-a-discov...

submitted 14 days ago • 22 comments

New from Jingyi's lab! www.biorxiv.org/content/10.1...

submitted 25 days ago • 0 comments

🧬💊 @science.org Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase | Science www.science.org/doi/10.1126/... @sternberglab.bsky.social @isaacwitte.bsky.social eitzingersimon.bsky.social + al. #CRISPR #Medicine #Science #Evolution #Genome #evoCAST

submitted 36 days ago • 0 comments

📣 🥳 🧑‍💻 Our department is hiring: Tenure-Track Assistant Professor / Associate Professor in Bioinformatics at Aarhus University, Denmark Deadline June 1st Thanks for sharing! mbg.au.dk/en/news-and-...

submitted 38 days ago • 0 comments

SMLM shows us how close molecules are, but just because two molecules are close doesn’t mean they’re bound. This new probabilistic framework changes that. They can actually quantify interactions at the single-molecule level. Fascinating! www.pnas.org/doi/abs/10.1...

submitted 38 days ago • 0 comments

Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals. www.science.org/doi/10.1126/...

submitted 38 days ago • 6 comments

Great story about our local student chapter of @asbmb.bsky.social here in @uwbiochem.bsky.social. I'm very happy to advise these amazing future scientists! biochem.wisc.edu/2025/05/08/a...

submitted 42 days ago • 0 comments

Gene regulatory interactions are assumed to be finely tuned. Yet, making (strong) promoters from random DNA sequences is remarkably easy ! De novo evolved promoters in E. coli exhibit low noise by default. 1/2

submitted 44 days ago • 1 comment

About time!

submitted 43 days ago • 1 comment

Thanks, Kelly, for sharing this picture. Looking forward to many more amazing science and wonder times in future meetings.

submitted 50 days ago • 0 comments

I’m both grateful and mad that this awesome woman paused her metastatic breast cancer fight to fly to DC and lobby for research funding. Janet Ramsey has had her life prolonged by clinical trials and is pushing our representatives to keep investing in life saving discoveries.

submitted 53 days ago • 2 comments

Five of our faculty discuss what inspires their research, their drive to innovate, and their entrepreneurial pursuits on and off the @uwmadison.bsky.social campus: biochem.wisc.edu/2025/04/14/f...

submitted 62 days ago • 0 comments

Interested in postdoc opportunities in Seattle, WA? Join us May 6th for Seattle DROP, a virtual event about biomedical research in Seattle. Hear from recruiting faculty, finding the right mentor and enjoy lunch on us via a delivery voucher within the US! Registration: tinyurl.com/seattledrop25

submitted 67 days ago • 1 comment

RFDiffusion2: a diffusion model that scaffolds enzyme active sites at the atomic level enables the generation of functional de novo enzymes www.biorxiv.org/content/10.1...

submitted 72 days ago • 0 comments

New preprint on 3D heterochromatin architecture in human cells! Great collab with @sergiocruzleon.bsky.social & @johannesbetz.bsky.social from @hummerlab.bsky.social, @marinalusic.bsky.social & the Turoňová lab. Many thanks to my supervisor @becklab.bsky.social. bioRxiv: tinyurl.com/3a74uanv 🧵👇

submitted 73 days ago • 3 comments

Congratulations to our lab's very own @elliott.weix.us on being awarded a Goldwater Scholarship! He's really an amazing and very accomplished young scientist and I couldn't be more proud of him 🥳🥳 ! news.wisc.edu/three-uw-mad...

submitted 74 days ago • 2 comments

Our department is looking to hire an Associate/Full Professor in the field of Virology. Please share and apply if you are intersted. Also happy to answer any questions recruit.ap.uci.edu/JPF09552

submitted 74 days ago • 0 comments

Swinging lever mechanism of myosin shown by time-resolved cryoEM www.nature.com/articles/s41... so glad to finally be able to share this with the community! @astburycentre.bsky.social @astbury-bsl.bsky.social @stemuench.bsky.social @snmcmillan.bsky.social @davidklebl.bsky.social

submitted 74 days ago • 2 comments

Excited to share our preprint “BoltzDesign1: Inverting All-Atom Structure Prediction Model for Generalized Biomolecular Binder Design” — a collaboration with @martinpacesa.bsky.social, @Zhidian Zhang, @Bruno E. Correia, and @sokrypton.org 🧬 Code will be released in a couple weeks

submitted 76 days ago • 5 comments

📢New opportunity for Lab technician!📢 If you're interested in #telomeres and #genomestability, and would like to join our team @gimmfoundation.bsky.social, don't miss this chance! Application details at gimm.pt/jobs/technic...

submitted 77 days ago • 0 comments

BoltzDesign1: Inverting All-Atom Structure Prediction Model for Generalized Biomolecular Binder Design by @yehlincho.bsky.social @martinpacesa.bsky.social @sokrypton.org 🧶🧬 www.biorxiv.org/content/10.1...

submitted 77 days ago • 1 comment

We’re looking for a multi-skilled Fluidic Automation Bioengineer to join John O’Neill’s group in the LMB’s Cell Biology Division, to develop novel platforms for drugging the circadian clock in cultured cells and tissues over many days. www.nature.com/naturecareer... Closes 24 APR #ScienceJobs

submitted 77 days ago • 0 comments

Tenure-track Faculty position just opened up in my department! If you want to be part of a dynamic group who is excited about science, apply. For more details, visit www.usherbrooke.ca/emplois/offr... Please share in your networks! #microsky

submitted 77 days ago • 0 comments

🔬 New from the Farnung Lab: We established a fully in vitro reconstituted chromatin replication system and report the first cryo-EM snapshots of the human replisome engaging nucleosomes. Brilliant work by @felixsteinruecke.bsky.social with support from @jonmarkert.bsky.social! tinyurl.com/replisome

submitted 78 days ago • 10 comments

Madison, WI #HandsOff 🥰🥰🥰

submitted 78 days ago • 12 comments

Could there be a better way to introduce ourselves to the Bluesky community than sharing our new review on the topic that fascinates us the most, the telomeric RNA TERRA? Check it out in the latest Telomeres and Telomerase collection of the Cold Spring Harbor Perspectives in Biology! ⬇️⬇️⬇️

submitted 78 days ago • 1 comment

A guide for Single Particle Tracking: from sample preparation and image acquisition to the analysis of individual trajectories https://www.biorxiv.org/content/10.1101/2025.04.03.647105v1

submitted 80 days ago • 0 comments

Yesterday we held the UW-Madison Indigenous Research Forum. I’m proud my postdoc Yowelunh McLester-Davis for organizing the conference, and to former Simcox lab undergrad Mariaya Jackson for winning second place award for a flash talk. My heart is full and ready to rise another day.

submitted 81 days ago • 1 comment