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crolltristan.bsky.social
Structural biologist and lover of all things biochemistry. Principal Scientist at Altos Labs. Developer of ISOLDE for macromolecular modelling in cryo-EM and Xtal maps: https://tristanic.github.io/isolde/
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Possibly the most evergreen Onion article in history: theonion.com/recession-pl...

submitted 45 days ago • 0 comments

Had a very long social media break after the last #SynchrotronMugMadness and the bird site's decent into horror. So hello bluesky, I'm a staff structural biologist helping @imperiallifesci.bsky.social solve protein structures with #crystallography and #CryoEM. Please enjoy these protein crystals 💎

submitted 162 days ago • 3 comments

Kids were complaining that their gaming laptop was getting a bit sluggish… 😳🤢

submitted 170 days ago • 1 comment

Interviewer: Can you explain this gap on your CV? Evolutionary biology: Well, yeah… but then I’ll have two *new* gaps you’ll want me to explain.

submitted 179 days ago • 0 comments

🎄 xmas preprint 🎄 we are excited to share our cryo-EM structure of UBR4 in complex with KCMF1 and CALM1. the PQC ligase forms a massive ubiquitination arena, primed to amplify ubiquitin chains (E4 activity) and boost degradation of defective proteins. www.biorxiv.org/content/10.1...

submitted 180 days ago • 4 comments

You know what they say about never releasing on a Friday… what does it say about me that I’m releasing on the last Friday before Christmas? 😬 Anyway, ISOLDE builds for ChimeraX 1.9 are now up. Enjoy!

submitted 181 days ago • 1 comment

An interesting finding that some types of HPV infection might be preventing cancer (as opposed to the ones that can cause it). Also features G.K. Chesterton and a brief cameo by RFK Jr.

submitted 183 days ago • 1 comment

Man… the fact that there’s a *second* ring galaxy visible in the gap? The sci-fi story (where these are the still-growing explosions from the past firing of some unimaginably powerful galaxy-killing beam weapon) practically writes itself.

submitted 185 days ago • 0 comments

Rare sighting of wild G-protein in Virginia

submitted 189 days ago • 5 comments

submitted 190 days ago • 0 comments

Structural biology people: @ucsfchimerax.bsky.social has entered the building.

submitted 197 days ago • 2 comments

Very excited to present the structural and mechanistic basis for stress response silencing by the monster E3 ligase SIFI. www.biorxiv.org/content/10.1...

submitted 199 days ago • 8 comments

Discussing Bluesky migration in terms of liberal flight misses the simple fact that most people use social media for fun not influence and this platform, unlike X and cruddified Facebook, doesn’t feel like you’re wading through shit to reach your friends. It’s not that deep.

submitted 215 days ago • 295 comments

… has anyone coined the term “Xit” yet?

submitted 216 days ago • 2 comments

For ISOLDE users who like to live on the edge: I uploaded dev builds for ChimeraX 1.8.dev… yesterday. While most things seem fine, if you want to use the “isolde add aa” command then *don’t* use this version. Something badly broken, killing the ChimeraX session.

submitted 449 days ago • 1 comment

Bugfix released! Unrelated, but I’d strongly recommend updating to ChimeraX 1.7.1 (particularly for Mac users - the 1.7 release inadvertently left out the Metal2 OpenMM implementation; 1.7.1 should get you back up to full speed).

submitted 510 days ago • 1 comment

Ahh, the pitfalls of software design… turns out ISOLDE breaks when you try to load an MTZ file containing only map coefficients (because I basically never use it that way myself, so didn’t notice when I broke it). Will try to push a fixed version out tomorrow.

submitted 511 days ago • 0 comments

Excited to share our first preprint of 2024! 🎉 researchsquare.com/article/rs-3... This study focuses on PDCoV, an emerging enteric pathogen. We generated anti-spike mAbs & investigated their inhibitory mechanisms using structural & functional studies. #virology #cryoEM

submitted 524 days ago • 2 comments

<ahem> This thing on?

submitted 524 days ago • 2 comments