ferag.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

We’re excited to share our review: "Next-generation genetic screens in kinetoplastids", now published in NAR! It covers a range of perturbation methods—from RNAi to prime editing—as well as emerging assay technologies like scRNA-seq and image-activated cell sorting. academic.oup.com/nar/article/...

submitted 1 day ago • 0 comments

Better late than never, but I am thrilled to share our newest research from the Treeck lab!!! www.nature.com/articles/s41...

submitted 1 day ago • 2 comments

A new paper from the Institute for Protein Design at UW presents RFpeptides, an extension of RoseTTAFold2 and RFdiffusion for de novo design of macrocyclic peptide binders www.nature.com/articles/s41...

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The rich are different because of the way we’ve been shaped by all the things that come with wealth: entitlement, impunity, narcissism, isolation, inability to share power, unwillingness to take criticism, to name a few. https://trib.al/Ep5QHmT

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AND IT'S DONE! A 🧵 on our recent article now out in @natsmb.nature.com! Co-led with @abbybartlett.bsky.social, Pagliarini Lab, @judisimcox.bsky.social, we find ACAD10/11 are NOT like other acyl-CoA dehydrogenases and instead catabolize atypical lipids called 4-hydroxy acids 🤯 doi.org/10.1038/s415...

submitted 2 days ago • 2 comments

Explore the important role of #genomics and data-driven technologies for accelerating advances in #AMRresearch, at our Antimicrobial Resistance meeting! #AMR2026 Discover the latest developments informing a dynamic global response to controlling this crisis. 🗓️ 23–25 March 2026 📎 bit.ly/3SWzJUm

submitted 4 days ago • 0 comments

Limited to US-only candidates.

submitted 4 days ago • 1 comment

The new #RDKit blog post, inspired by a question from @valencekjell.com, looks at the impact of molecular size on similarity thresholds. greglandrum.github.io/rdkit-blog/p...

submitted 5 days ago • 3 comments

🚨 Results of CACHE Challenge #4 are in! 🚨 This challenge focused on identifying novel hits for CBLB, a cancer immunotherapy target that has so far proven difficult to identify novel chemical scaffold for. Read the press release here: conscience.ca/news/cache-c...

submitted 8 days ago • 0 comments

CACHE4 results are out! All previously known CBLCB ligands shared the same scaffold. Congrats to Keunwan Park who successfully designed a chemically novel series, to the experimental team at @thesgc.bsky.social and thanks to @conscience-network.bsky.social for greasing the wheels! bit.ly/4mYNe3r

submitted 8 days ago • 0 comments

MICROEXONS! 💪 Not only are they included in neuronal transcripts, but they are also alternatively spliced between neuron types! We unpack their regulation and function 👇 @emboreports.org www.embopress.org/doi/full/10....

submitted 8 days ago • 1 comment

Inverse protein folding—designing sequences from structures—remains tough. In my latest post, I discuss MapDiff, an innovative diffusion-based approach by Bai and coauthors that significantly advances protein design and engineering. Full details here: open.substack.com/pub/bravoaba...

submitted 7 days ago • 0 comments

Published now. doi.org/10.1242/jcs....

submitted 14 days ago • 1 comment

Adding fatty acids is indeed a great AF3 trick for many membrane proteins

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🔥 Time for my first bioML blog post! This one is for all the folks getting into ML-for-protein-design. ✨ "Just know stuff, proteinML edition" kidger.site/thoughts/jus... This is intended as a curriculum-with-context, as a starting point for the field. 1/2

submitted 35 days ago • 1 comment

Highly cross-reactive and competent effectors dominate the CD8+ T cell response in Trypanosoma cruzi infection @jimmunol.bsky.social academic.oup.com/jimmunol/adv...

submitted 6 days ago • 1 comment

🚀 After two+ years of intense research, we’re thrilled to introduce Skala — a scalable deep learning density functional that hits chemical accuracy on atomization energies and matches hybrid-level accuracy on main group chemistry — all at the cost of semi-local DFT ⚛️🔥🧪🧬

submitted 6 days ago • 3 comments

Microsoft researchers achieved a breakthrough in the accuracy of DFT, a method for predicting the properties of molecules and materials, by using deep learning. This work can lead to better batteries, green fertilizers, precision drug discovery, and more. www.microsoft.com/en-us/resear...

submitted 6 days ago • 2 comments

Another triumph for scientists fighting to protect people from HIV - a new drug that virtually stops transmission. Could be the breakthrough that ends AIDS. Scientists did their job. Now politicians must do theirs by ensuring access to those who need it most. www.nbcnews.com/news/amp/rcn...

submitted 6 days ago • 0 comments

New hope for hard-to-treat fungal infections: Phase 2b results show #Olorofim is effective and well-tolerated in patients with few or no treatment options. Read in The Lancet Infectious Diseases 👉 www.sciencedirect.com/science/arti... #IFD #Antifungals #ClinicalTrials

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🚨New publication alert! 🚨Our latest study on GPM6a variants and its role in neuron development is just out 🧠✨🔗 Read it here: sciencedirect.com/science/arti...

submitted 133 days ago • 1 comment

Molecular glue meets antibody: next-generation antibody–drug conjugates

submitted 8 days ago • 0 comments

My latest @newscientist.com cartoon

submitted 10 days ago • 20 comments

New preprint! Deacon is a versatile tool for filtering FASTA/FASTQ files and streams at hundreds of megabases per second using minimizers, built with rapid metagenomic host depletion in mind, but equally useful for search. github.com/bede/deacon

submitted 11 days ago • 5 comments

TIME CHANGE - Because of a public holiday, we have moved the next seminar to Monday June 16 at 3pm CET. Tune in to hear from Dr. Lucía Chemes (@unsamoficial.bsky.social) and Julian van Gerwen (@julianvangerwen.bsky.social). Register to attend: tinyurl.com/PMCseminar2 (1/2)

submitted 18 days ago • 1 comment

“Since COVID governments have started to realise that without diagnostics there is no means of stopping transmission...” On the EMJ podcast, Rosanna Peeling discusses diagnostics in #GlobalHealth & managing disease control & #pandemic preparedness. www.emjreviews.com/microbiology...

submitted 11 days ago • 0 comments

The Fungal Kingdom as a Rosetta Stone for biological discovery – a long-time Current Biology advisory board member, Joseph Heitman, introduces the special issue on ‘The Fungi’. www.cell.com/current-biol...

submitted 13 days ago • 1 comment

Dynamic excision of the F13 hlb-converting prophage in Staph. aureus is critical for full virulence, new study reveals. Loss of F13 restores β-hemolysin expression and enhances pathogenicity, while locking the prophage impairs infection. #MicroSky ✍️ O. Poupel & coll @pasteur.fr 📖 shorturl.at/F1W3t

submitted 11 days ago • 1 comment

🚀 Healx is launching a new blog series on practical, open-source workflows for drug discovery! First up: a KNIME + ChEMBL pipeline to explore compound-target interactions. Big thanks to #RDKit, ChEMBL, UniChem & KNIME! 🧪 Read more: medium.com/low-code-for...

submitted 12 days ago • 1 comment

Drugit: crowd-sourcing molecular design of non-peptidic VHL binders

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🚀 Our paper on the updated PrankWeb, a web app for protein binding site prediction using P2Rank, is out in @narjournal.bsky.social. Now with docking integration! 👨‍💻 Try it: prankweb.cz 📄 Paper: doi.org/10.1093/nar/... 💻 GitHub: github.com/cusbg/prankweb Developed at @cusbg.bsky.social

submitted 14 days ago • 2 comments

Bursaries to support reference genome enthusiasts to attend our new #Biodiversity25 conference 💰 Apply by 14 July to be considered - abstracts welcome! 📩 Participate in discussion to strengthen #biodiversity data dissemination, and the analysis of #eukaryotic genomes at scale🌳 📎 bit.ly/4j3vAZ9

submitted 13 days ago • 0 comments

How do dormant cells keep their proteostasis in check? @gzaffagnini.bsky.social & our PhD student Stephanie Rosswag take a deep dive in our featured review @cp-trendsbiochem.bsky.social Don’t miss it! - EB www.sciencedirect.com/science/arti...

submitted 13 days ago • 0 comments

From UGA Research News - Kurup wins prestigious PATH award for groundbreaking malaria research research.uga.edu/news/kurup-w... #bwfpath

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Teaching bioinformatics? Galaxy’s Learning Pathways offer ready-to-use project ideas perfect for the classroom or student-led research. Step-by-step tutorials ✅ Real-world datasets ✅ No installation needed ✅ Explore Learning Pathways: training.galaxyproject.org/training-mat... #STEMeducation

submitted 13 days ago • 0 comments

Coming to America 'First published in 1964 in the Argentine weekly “Primera Plana” — with material originally drawn for an unrealized ad campaign for home appliances — “Mafalda” blends cutting satire with playful humor, layered with meanings that appeal to readers young and old.'

submitted 13 days ago • 2 comments

transcriptionists take note 👇 gRNA + dCas12f + σE > new promoter 👀 #MicroSky #RNASky

submitted 13 days ago • 2 comments

New from The Strain Team: 🎊 Springer Nature Discovers MDPI 🎊 Springer Nature has spawned a copycat journal series called "Discover" mimicking #MDPI journal titles and citation behaviours. We even made a browser game to prove it (see 🔗). Gross! 😀 1/n #ResearchIntegrity #SciPub #AcademicSky

submitted 15 days ago • 11 comments

Now how the heck did Novo Nordisk end up with such poor patent coverage for Ozempic/Wegovy in Canada? Incompetence cannot be ruled out:

submitted 13 days ago • 5 comments

Thanks to Jakob Franke for highlighting the Taxol/FoTO1 gene discovery and the mpXsn approach spearheaded by @cmcclune.bsky.social in @nature.com! Check it out here: www.nature.com/articles/d41... #plants #anti-cancer #singlecell #plantbiology

submitted 13 days ago • 2 comments

(Longish thread. Apologies) I have met many inspiring colleagues over the past few months, many of whom are in academic institutions targeted by the current administration, and many others who are about to be (the analogy to the ‘eye of Sauron’ has been invoked many times; gallows humor). 1/

submitted 16 days ago • 10 comments

We are developing a simple, very cheap, low tech way to reduce malaria transmission. Instead of giving the antimalarials to people, we give them to the mosquitoes that spread the parasite. How do we drug a mosquito? Read on. www.sciencedirect.com/science/arti...

submitted 17 days ago • 1 comment

Wanted to highlight our latest preprint--a huge effort by multiple people and labs, but led primarily by @wsdewitt.github.io, Tatsuya Araki, and Ashni Vora, in a very close wet-dry collaboration with @matsen.bsky.social’s lab at the Hutch www.biorxiv.org/content/10.1...

submitted 19 days ago • 1 comment

Thrilled to share that my first #micropublication is out! 🧬🔬 I created a user-friendly ImageJ/FIJI plugin for nuclear segmentation and multi-channel fluorescence analysis that doesn't require programming skills. www.micropublication.org/journals/bio...

submitted 17 days ago • 2 comments