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folpe-mn-st.bsky.social
I like my wife and family, bikes, music, dogs, baking bread and soft tissue tumors. Only the last here though.
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#PathSky Laryngeal mass, older adult male. Primitive, highly vascular round cell neoplasm for the most part.

#PathSky 53F with shortness of breath and “ground glass” pulmonary opacity. Not a hard dx, but a spectacular (if very unfortunate) case.

#PathSky Abdominal wall mass, middle aged woman. Women basically only get 3 abdominal wall tumors, so it’s got to be a desmoid, DFSP or endometriosis. Classic desmoid morphology, aberrant nuclear beta-catenin. I can hear the cries of “boring..”

#PathSky Someone shared a chest wall Ewing sarcoma with me today, and I queried them about exactly what they were Askin. I should probably retire today.

#PathSky Middle aged woman, leg mass. It all looks like this. More nuclear palisading/ Verocay bodies than you’ve seen in your entire career. Nerve sheath? S100/Sox10 negative. LMS? Negative for all the muscle markers. Any other ideas?

#PathSky Right femur lesion in an older woman. Diffusely keratin-positive with 3 different antibodies.

#PathSky 45 with a forearm skin tumor. Highly cellular, monomorphic spindle cell tumor with a “packeted” pattern and deep, nodular lymphoid aggregates.

#PathSky Large, left sided abdominal/retroperitoneal mass in an older adult. Spindle cell proliferation with associated inflammation. All the outside IHC were negative. What to do next? MDM2 FISH? NGS? Methylation?

#PathSky 43M, forearm mass. At first glance, it looks like some kind of inflammatory process, maybe a synovitis with plasma cells, fibrosis and foamy macrophages.

#PathSky 55F, large retroperitoneal mass. Outside pathologist quite reasonably thought of WDL, but MDM2 FISH was negative. Any other ideas?

#PathSky Large, myxoid paraspinal mass, 79M. Transferred from HemePath to BST as “myxoid sarcoma”. MDM2 was negative.

#PathSky Middle-aged woman with a long-standing neck mass.