gati.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Does the brain learn by gradient descent? It's a pleasure to share our paper at @cp-cell.bsky.social, showing how mice learning over long timescales display key hallmarks of gradient descent (GD). The culmination of my PhD supervised by @laklab.bsky.social, @saxelab.bsky.social and Rafal Bogacz!

submitted 1 day ago • 4 comments

New work from our lab. Structures of K2P6.1 (TWIK2) that yield a new and suprising perspective on how lipids affect K2P channels. Great work from Abishek Mondal and Sangeeta Niranjan in my lab. www.biorxiv.org/content/10.1...

submitted 15 hours ago • 0 comments

A small-molecule STING agonist is conjugated to a nanobody that binds to serum albumins to increase tumor accumulation and augment antitumor immunity www.nature.com/articles/s41... www.nature.com/articles/s41...

submitted 4 days ago • 0 comments

An exciting Postdoc opportunity for a computational biophysicists, interested in #cryoEM image analysis/methods development, to join a #phenix subgroup. Competitive salary and #BestViewFromALab included. Please share! @kpande.bsky.social jobs.lbl.gov/jobs/computa...

submitted 5 days ago • 1 comment

These are con-artists. And I feel like I'm going crazy because so few people recognize them when it used to be a very common skill most people had!

submitted 6 days ago • 100 comments

Our latest paper w/ @pottslab.bsky.social & @amgen.bsky.social in @jacs.acspublications.org by co-first authors @cmzammit.bsky.social & Cory Nadel on discovery of covalent destabilizing degrader of AR & AR-V7 in prostate cancer. Thanks also to @themarkfdn.bsky.social ! pubs.acs.org/doi/10.1021/...

submitted 6 days ago • 0 comments

The structural basis of cold sensitivity www.biorxiv.org/content/10.1101/2025.06.06.658377v1 #cryoEM

submitted 7 days ago • 0 comments

A huge congrats to Jeppe Nielsen who defended his PhD thesis with excellence! An outstanding accomplishment! Thanks to profs. Harald Sitte, @poulnissen.bsky.social and Petrine Wellendorph for an inspiring assessment.

submitted 8 days ago • 0 comments

New preprint in the lab combining what we like best: insects, love, chemistry and the olfactory system! 1/8 www.biorxiv.org/content/10.1...

submitted 12 days ago • 1 comment

Excited to present our newest preprint on the structure-function relationship of anaphylatoxin complement receptors. A casual number of 19 structures deciphering ligand recognition mechanisms, G protein/arrestin and species specific signaling. Please check it out! 🧪💊 www.biorxiv.org/content/bior...

submitted 16 days ago • 0 comments

Very special feelings to announce this one... A project that started like 10 years ago is reaching the finish line, ready to shine. In a dream-team with @beckmannlab.bsky.social we solved the long-chased structure of the active membrane protein insertase SecYEG-YidC www.biorxiv.org/content/10.1...

submitted 20 days ago • 7 comments

1/10 Today in @science.org in collaboration with the Liu group we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells. drive.google.com/file/d/1I-Ub...

submitted 31 days ago • 2 comments

An amazing new enabling technology. Measurements of molecular size and shape on a chip. Couldn't be prouder of our friend Madhavi Krishnan of @ox.ac.uk this was and is one among the must fun collaborations I ever had. www.science.org/doi/10.1126/...

submitted 38 days ago • 8 comments

Happy to share we got the NoA for the NIH S10 proposal I submitted for a Glacios #cryoEM 🔬 for #IowaResearch #structuralbiology

submitted 40 days ago • 3 comments

🧠💰K99/R00 NoA day! Huge congrats to Dr Blake Kimmey … #GameOn 🔥🍾🙌🏼 Gonna brag on this guy and say he’s on job market this year and he can bring this kinda cutting-edge placebo / pain / addiction systems-circuit neuro research to your department: pubmed.ncbi.nlm.nih.gov/39803541/

submitted 40 days ago • 2 comments

Out today, we report how small chemical modifications in the metabolism of ergosterol are needed for yeast membranes to phase seperate into ordered yet fluid domains www.science.org/doi/10.1126/... (1/n)

submitted 52 days ago • 4 comments

Super happy to share that our work on the specific inhibition of USP30 - a clinical stage Parkinson's drug target - is now online at NSMB www.nature.com/articles/s41... Have a read if you fancy chimeric protein engineering or a framework for DUB ligandability. Huge congratulations to Nafizul & team!

submitted 42 days ago • 3 comments

Nice visit to the lovely Princeton campus. Could not be prouder of @automnenine.bsky.social. For those who are looking for a postdoc, there are exciting opportunities to join his lab!

submitted 41 days ago • 1 comment

My first time at #usasp2025. Great science, new and old friends. First talk in a symposium at an international conference. Thank you to my co-speakers @stefpuig.bsky.social and Ream Al-Asani

submitted 44 days ago • 0 comments

Friends, if anyone is looking for an electron microscopist outside of the US, I'm listening. Open to any country, regardless of weather. Can do cryo, room temp, image anything from tissues to nanoparticles, viruses, catalysts, etc. Thanks for any lead(s).

submitted 45 days ago • 3 comments

Excited to see this out in @science.org today!! www.science.org/doi/10.1126/...

submitted 45 days ago • 6 comments

Congratulations to Katalin Karikó (@PennNSG), Virginia Lee (@pennpathlabmed.bsky.social), @ejohnwherry.bsky.social (@PennSysPharmATT) & Mark Devlin (@physatpenn) on their election to @nasonline.org! tinyurl.com/5eehdtms

submitted 46 days ago • 0 comments

Honored and humbled. I have been very fortunate to have worked with amazing, inspirational colleagues in my lab, at Penn and in the broader community. Science matters www.nasonline.org/news/2025-na...

submitted 47 days ago • 26 comments

“Join the Pigino Lab! We’re hiring a PhD student to explore primary cilia biology using advanced imaging, spatial ‘omics, and AI. Apply now at www.cilia-ai.eu and be part of the Cilia-AI Doctoral Network!”

submitted 116 days ago • 0 comments

tinyurl.com/mrce6bbb Fun to write this N&V together with Regina @hrshin.bsky.social, on the several cryoEM papers that build on her discovery of the fascinating LYCHOS protein and its role in cholesterol sensing and mTORC1 regulation!

submitted 48 days ago • 0 comments

🚀 Check out our latest paper on the selectivity of sugar transport in plants👇 Amazing work initiated by ⭐Laust Bavnhøj and spearheaded by 💫Camilla Andersen: www.pnas.org/doi/10.1073/... Also 💎💎💎💎 CRYSTALS💎💎💎💎

submitted 49 days ago • 1 comment

Beyond excited to present our study on the glycine transporter #GlyT2, a promising #non-opioid target for the treatment of neuropathic pain. @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...

submitted 52 days ago • 2 comments

Dear al, check out our latest paper with @uhammes.bsky.social . A great collaborative effort by Lukas and Lam!!

submitted 55 days ago • 0 comments

I'm excited to share our lab's newest publication on the structure and pharmacology of human GABA transporter 3 @natcomms.nature.com. Much to our surprise, GAT3 adopts an inward-open conformation in complex with the (moderately) selective antagonist SNAP-5114. 💊 🧪 #CryoEM #OpenAccess rdcu.be/ei2KY

submitted 53 days ago • 3 comments

We are looking for a postdoctoral fellow to join us to explore telomerase regulation by histones. Please get in touch if this may interest you.

submitted 60 days ago • 0 comments

#CryoSPARC v4.7 is out! 🚀 Featuring a new automatic Micrograph Junk Detector that labels and rejects contaminants, new tools for curating subsets of particles, performance and stability fixes, and more! Full changelog: cryosparc.com/updates #cryoEM

submitted 68 days ago • 1 comment

Excited to share work led by Preston Anderson and Peng Xiao in collaboration with Jinpeng Sun (just like old times when we were postdocs in Lefko lab). We find that beta-arrestins form biomolecular condensates to regulate GPCR function - www.biorxiv.org/content/10.1...

submitted 68 days ago • 2 comments

Filizola lab - Gmeiner lab finally revealed onlinelibrary.wiley.com/doi/abs/10.1...

submitted 69 days ago • 0 comments

THIS IS HUGE! Researchers at the University of Pennsylvania have developed an antiviral chewing gum that may help reduce the spread of viruses. In lab studies, it cut down viral loads of two herpes simplex viruses (HSV-1 and HSV-2) and two influenza A strains (H1N1 and H3N2) by more than 95%. 🧪🧵⬇️

submitted 69 days ago • 117 comments

🔥🔥🔥

submitted 71 days ago • 0 comments

… a good day

submitted 74 days ago • 3 comments

Counting particles could give wrong probabilities in Cryo-Electron Microscopy www.biorxiv.org/content/10.1101/2025.03.27.644168v1 #cryoEM

submitted 79 days ago • 0 comments

Check out our latest - we found that complex terpene extracts from Cannabis had similar pain relief and cannabimimetic effects as purified single terpenes, and also via the same target, the adenosine a2a receptor. Free share link! url.usb.m.mimecastprotect.com/s/Uq14CnGWL0...

submitted 81 days ago • 3 comments

Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/... @wehi-research.bsky.social @komanderlab.bsky.social

submitted 94 days ago • 9 comments

Proud to share this work from my group in the intramural research program at NIH! We describe a new kind of conjugate made from a small molecule adenosine analog linked to a GPCR targeting nanobody to make antibody drug conjugates that potently and specifically activate signaling (1/n) 🧪 #chembio

submitted 95 days ago • 1 comment

Very proud of our new review article on the Beta 1-Adrenergic GPCR now available on bioRxiv: www.biorxiv.org/content/10.1.... With @saureli.bsky.social @valeriorizzi.bsky.social and Nicola we used OneOPES to fully converge the free energy landscapes associated with B1AR apo/holo activation.

submitted 96 days ago • 0 comments

Interesting paper about how to find out whether ligands affect a receptor's conformation via induced fit or via conformational selection. www.biorxiv.org/content/10.1...

submitted 98 days ago • 1 comment

FRESH OFF THE PRESS @filizolalab1 : Fine-Tuned Deep Transfer Learning Models for Large Screenings of Safer Drugs Targeting Class A GPCRs | Biochemistry pubs.acs.org/doi/full/10....

submitted 99 days ago • 0 comments

Poll Finds Most Americans Would Swap Democracy For $100 Best Buy Gift Card theonion.com/poll-fi...

submitted 99 days ago • 294 comments

Emily Whitehead and her father on CNN with Jake Tapper speaking to the value of science. She is alive thanks to CAR T therapy developed at Penn and CHOP.

submitted 100 days ago • 1 comment

Excited to share our latest work, led by the incredible @automnenine.bsky.social (now an Ass. Prof. at Princeton)! We uncover key insights into the retrotransposition mechanisms of LINE-1 ORF2p, the enzyme responsible for writing a significant portion of our genome. www.science.org/doi/10.1126/...

submitted 101 days ago • 8 comments