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gholsonlyon.bsky.social
physician-scientist; rare diseases; child, adolescent, adult psychiatry, Institute for Basic Research in Developmental Disabilities, & professor at CUNY
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David Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏 youtu.be/8YhJM6zxYDw?...

On Friday, my son stayed home from school because he had a sore throat and wasn’t feeling well. He went with my husband to his office for the morning while I handled our daughter. When he came back at lunch, he was not interested in eating, saying his throat hurt too much. 1/n

Amazing move Sinners. This interview goes into some of the symbolism. Highly recommend watching it in theaters. I went to IMAX last weekend and loved it! www.youtube.com/watch?v=0mU_...

I have basically given up on trusting any journal or any peer review process. You have to read the article for yourself, sadly, as peer review can be absolute garbage in many instances, as all of us are so busy with so many other tasks. Just sad that journals still are the major gatekeeper.

just published finally. The Cardiovascular Manifestations and ManagementRecommendations for Ogden Syndrome rdcu.be/ejNYr

The Grand Egyptian Museum, outside Cairo, has been delayed by revolutions, wars, financial crises and a pandemic. At long last, here’s a look inside.

aside: a stunning comment from David Baker, UW professor who won the Nobel Prize in 2024. Now 15 lab members are looking for positions overseas. “There’s so many amazing people who want to come in, & we can’t take them. The Nobel Prize was just a little blip. But things have gotten quite bleak.”

They were careless people, Tom and Daisy- they smashed up things and creatures and then retreated back into their money or their vast carelessness or whatever it was that kept them together, and let other people clean up the mess they had made. -FS Fitzgerald, The Great Gatsby, published 4/10/1925.

Fraser Stoddart (1942-2024) Guardian obituary #chemsky 🧪 www.theguardian.com/science/2025...

The Atlantic story on the situation at NIH is sobering. We are so screwed. www.theatlantic.com/health/archi...

www.science.org/content/arti...

I was talking with my sister about how weird it was that people used the Four Humors theory even into the 20th century, isn’t it so stupid to reduce everything to these chemical systems? And she said “Look at the way people talk about dopamine, serotonin, and oxytocin on TikTok” Huh.

A source close to the situation confirmed that study sections are continuing to be cancelled. On the chopping block this week: developmental brain disorders, mechanisms of cancer therapy, and neurotoxicology of alcohol. For some labs, this was the last chance to get funding or they’ll shut down.

Don't be a useful idiot puppet for the regime drugmonkey.wordpress.com/2025/02/25/d...

We need to make sure that everyone understands how important science is for EVERYONE not just for scientists...

Bluebird bio to sell to investment funds after struggling to make money from gene therapies. endpts.com/bluebird-bio...

Over on LinkedIn, the head of the Executive Secretariat of the NIH -- a central part of NIH leadership 🧪🩺-- resigned with a lettter worth reading www.linkedin.com/posts/nathan...

FDA’s former top food official says Trump firings are ‘dismantling’ the division www.statnews.com/2025/02/18/f... via @statnews.com

When I talk to kids today and they ask me what I would do if I were 12 today, my answer is always the same, read books and learn how to use AI in every way shape and form you can. It is a living library that gives you responses and can help no matter who you are or where you live.

Big, growing crowd just west of the U.S. Capitol protesting Trump, Musk and DOGE on President’s Day. “Hey Congress, grow a spine,” they shout, gathering for a rally around the reflecting pool.

From Harold Varmus (Former NIH and NCI Director and Nobel laureate) Why Would We Undermine the Marvel of American Science? www.nytimes.com/2025/02/14/o...

sad. Head of ARPA-H and Biden appointee Renee Wegrzyn told staff Friday morning that she was fired, a source told STAT. www.statnews.com/2025/02/14/f...

New preprint. The Cardiovascular Manifestations and Management Recommendations for Ogden Syndrome. www.medrxiv.org/content/10.1...

Not doing much with social media anymore. Not sure I want to bother. I have been reading tons of great literature lately. Just bought the Letters of Oliver Sacks to read, beyond his books. www.amazon.com/dp/045149291... I have been re-reading Freud too, along with some A.R. Luria, before them.....

I had already decreased my plastics use, but will re-double my efforts on this, including not drinking from small plastic water bottles. I do already filter my water with a Brita filter....

A new paper on microplastics accumulating in the brain was just published in Nature Medicine. I've reviewed the background and main findings in a new Ground Truths post erictopol.substack.com/p/the-microp...

Cool! Dysregulation of mTOR signalling is a converging mechanism in lissencephaly. www.nature.com/articles/s41...

I opened that other site (X) for the first time in a few weeks, then was inundated with horrible news articles and negativity. I immediately closed it again. For now, I am loving some great literature, at this amazing book club: www.patreon.com/c/hardcoreli...

Love hearing inside stories behind NIH programs like the New Innovators Award from @jeremymberg.bsky.social !

youtu.be/EkX8Y5sNg3U

Opinion | The exodus from X to Bluesky has happened – the era of mass social media platforms is over - The Guardian

Waves of new BlueSky arrivals in last few days! I’ve been tracking starter packs relevant to molecular/mechanistic/genetic/cellular…etc biology Hope it’s helpful but warning: now a v long thread! Probably the last time I can do this...

glad to see this published: A framework for N-of-1 trials of individualized gene-targeted therapies for genetic diseases www.nature.com/articles/s41...

The Salk Institute shared the sad news that Prof. Joanne Chory passed away yesterday due to complications from Parkinson’s disease. She was one of the most influential biologists of our time. And this is how I will remember Joanne, expertly guiding us on where to go. Joanne, we will miss you! ❤️

about Child Neurology meeting in San Diego. www.linkedin.com/posts/gholso...

Reminder for newcomers that bioRxiv has Bluesky accounts in every subject category - great way to keep up (please re-skeet) connect.biorxiv.org/news/2023/09...

Today would have been Carl Sagan's 90th birthday. He wrote this in 1995. Carl was absolutely right. #CarlSaganDay

My favorite painting at Denver Art Museum, not surprisingly: The Family of Street Acrobats: the Injured Child (La Famille du Saltimbanque: L'Enfant BlessĂŠ) 1873 Artist Gustave DorĂŠ, French, 1832-1883 denverartmuseum.org/en/object/20...

“Look for the helpers” ~ Fred Rogers Key advice for young scientists getting started in academia. Find the givers & stay away from the takers. I have seen SO many sr faculty take advantage of junior faculty over my 25-year career as a professor.