gokcegroup.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

I'm excited to share our latest pre-print on proximity proteomics of primary cilia in human hypothalamic neurons, led by Viviana Macarelli, which revealed proteins involved in synapses and neurotransmission and the obesity-associated GPCR LPAR1. Details at bit.ly/4jcTodq

submitted 3 hours ago • 0 comments

This is (unfortunately) the truth. Thanks to @labonnelab.bsky.social for writing this When trying to understand how organs and organ systems work, and how diseases affect them, reductionist in vitro models (or 'AI') do not come close to in vivo studies

submitted 1 day ago • 0 comments

Why do the brain’s professional phagocytes stop clearing amyloid in Alzheimer’s disease? Can we restore microglial superpowers & rescue dying neurons in AD? YES, by stopping DGAT2-mediated lipid droplet formation! Checkout our latest manuscript @cp-immunity.bsky.social 👇🏼 www.cell.com/immunity/abs...

submitted 1 day ago • 4 comments

This is what can be achieved today due to longstanding federal support of academic basic science alongside close partnership of universities, private industry and NIH intramural initiatives. An ecosystem worth not just saving but doubling down on! innovativegenomics.org/news/first-p...

submitted 5 days ago • 3 comments

Excited to see this collection out! Thank you to all the authors and reviewers who contributed!

submitted 7 days ago • 0 comments

Let’s get the word out about the importance of federal funding of curiosity -driven science We all have similar stories to share

submitted 10 days ago • 1 comment

We are looking for additional Group Leaders to join the growing computational biology community at VIB. If you are excited about combining AI and machine learning with fundamental biology, we would love to hear from you! https://vib.ai/en/opportunities#/job-description/110906

submitted 24 days ago • 0 comments

Excited to dive into special issue on neuro-immune axis! Happy to share our review on microglia states and function by the Dynamic Microglia duo Constanze Depp and Jordan Doman Thank you @KavithaSci @ImmunityCP for the opportunity cell.com/immunity/libra…www.cell.com/immuni/newar...es

submitted 14 days ago • 1 comment

Microbiota-shaped neutrophil senescence regulates sexual dimorphism in bladder cancer www.nature.com/articles/s41... Interesting work where Zhu et al demonstrate that gut microbiota regulates sexually dimorphic antitumor immunity and bladder cancer progression

submitted 14 days ago • 0 comments

Europe’s choice is clear. To put science at the heart of its economy. To become the home of scientific freedom and collaboration. And to welcome talent from all over the world. I’m glad to present the first elements of our Choose Europe Initiative. → europa.eu/!TTbWbJ

submitted 15 days ago • 128 comments

Time to catch up on the past week’s news about science and medicine in the US. Whew. 1/10

submitted 18 days ago • 27 comments

Check out this paper from the Movahedi lab! It’s a great companion to ours - showing the populations of brain macrophages that monocytes can replace. Congrats to first author Jonathan Bastos!

submitted 19 days ago • 0 comments

…and that’s a wrap! Great #MIF meeting in Louisville - big thanks to co-organizers Bob Mitchell and Ashley Curry. Great to see the MIF community and many friends - @gokcegroup.bsky.social @karenenglish.bsky.social

submitted 19 days ago • 0 comments

It was fun to learn about blood vessel organoids together with @marinanikolova.bsky.social and Barbara Treutlein! Thanks to Reiner Wimmer and @penningerlab.bsky.social for introducing us to this system! www.cell.com/cell/fulltex... Great support from editors and reviewers @cellpress.bsky.social!

submitted 22 days ago • 1 comment

PhD Timeline xkcd.com/3081

submitted 25 days ago • 614 comments

Read our newest publication @jem.org about #microglia and #CD8Tcell interactions in spastic paraplegia! 💡Immune activation happens before #neuronal loss! 💡 Team effort with the labs of Marc Beyer and Ralf Stumm 👇 doi.org/10.1084/jem.... @limes-bonn.bsky.social @immunosens.bsky.social #immunosky

submitted 27 days ago • 4 comments

Microglia & monocyte-derived cells were long assumed to have similar functions during remyelination. Our new paper @plosbiology.org shows non-redundant roles, with monocytes ultimately inhibiting remyelination. Team effort by Bianca Hill,Rebecca Holloway, Lindsey Forbes,Claire Davies plos.io/3RryCLF

submitted 27 days ago • 2 comments

I recenty did a podcast about our work in the lab @ukdri.ac.uk @uclqsion.bsky.social to understand the mechanisms that cause FTD/ALS check it out here: SoundCloud on.soundcloud.com/xs6j9EcMbTRW... - Apple Podcasts podcasts.apple.com/it/podcast/n... - Spotify open.spotify.com/episode/7cnY...

submitted 33 days ago • 0 comments

Silencing of transgenes during iPSC differentiation is a frequent problem. 🧬🫢 Check out the piggyBac system below, which has resisted silencing in many protocols across many labs. 💪 Excited that our lab could contribute to this team effort led by @tuenaka.bsky.social & Marius Wernig!

submitted 34 days ago • 0 comments

Harvard has set an example for other higher-ed institutions - rejecting an unlawful and ham-handed attempt to stifle academic freedom, while taking steps to make sure students can benefit from an environment of intellectual inquiry, rigorous debate and mutual respect. Let’s hope others follow suit.

submitted 35 days ago • 1664 comments

Interested in cellular mechanisms of cognitive decline after stroke? Check out this work in Nature communications: Anna-Sophia Wahl lab track the fate of individual neurons involved in spatial memory before + after multiple, distributed microstrokes using chronic 2photon imaging in-vivo. 👍

submitted 36 days ago • 0 comments

#AReminderResourcesAreFinite #WhatDoWeGainFromADeadPlanetRethuglicans ⁉️

submitted 39 days ago • 0 comments

Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social, @marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social 🔗 Preprint here tinyurl.com/3a74uanv

submitted 39 days ago • 12 comments

In @nature.com today we report sensory #assembloids comprising four parts to recapitulate aspects of the pathway that processes pain stimuli and we use it to study genetic syndromes. Work pioneered by the brilliant Ji-il Kim & Kent Imaizumi in close collab with @gregscherrer.bsky.social ! Link 👇

submitted 40 days ago • 3 comments

A package of research papers from the MICrONS (Machine Intelligence from Cortical Networks) consortium in Nature and Nature Methods provides a detailed map of mouse brain cell structure and connections, offering insights into how they relate to activity in the mouse brain. 🧪

submitted 41 days ago • 1 comment

Do you know the 8 action items to make levodopa fully available in Africa? Did you know the problem is a worldwide one? Can you imagine that we have dopamine pills for Parkinson's, and some people on earth can't get it?

submitted 43 days ago • 0 comments

What a success, dear Rajula! We congratulate you on this milestone 🎉

submitted 43 days ago • 0 comments

Thanks to FOX24News for having me on to spotlight #CADASIL. I hope this gives insight into this disease and highlights why we believe targeting blood vessels is key to developing effective treatments #VCID #EndDementia. More info below 👇 www.elahilab.com/

submitted 160 days ago • 0 comments

Inside you are two wolves

submitted 44 days ago • 0 comments

Raj Lab @ #ADPD2025: Tatsuhiko Naito on mosaic chromosomal alterations (mCA) in #Alzhiemer’s (ID 1090, Fri 17:50, Hall F2) & Mikaela Rosen on scRNA-seq of PBMCs & T cells in #Parkinson’s (ID 1462, on demand).

submitted 46 days ago • 0 comments

Very proud of two new preprints from the lab: 1) CREsted: to train sequence-to-function deep learning models on scATAC-seq atlases, and use them to decipher enhancer logic and design synthetic enhancers. This has been a wonderful lab-wide collaborative effort. www.biorxiv.org/content/10.1...

submitted 46 days ago • 5 comments