henajose.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

When science fiction becomes science fact: in a triumph of science based personalized therapy a baby with a unique fatal #genetic disease was saved by a bespoke #CRISPR approach. Unthinkable 20 years ago. www.nature.com/articles/d41...

submitted 17 days ago • 0 comments

An atlas of tissue-specific protein-protein associations helps to prioritise targets for drug discovery www.ppiatlas.com?ref=blog.ope...

submitted 26 days ago • 0 comments

Computer scientists and bioinformaticians address four key questions to help rookie coders to make the right choice https://go.nature.com/42UuoT3

submitted 40 days ago • 3 comments

Implicates 700 effector genes and highlight eight biological processes including the circadian clock, glial-cell-related processes and pathways with an established role in osteoarthritis (TGFβ, FGF, WNT, BMP and retinoic acid signalling, and extracellular matrix organization)

submitted 42 days ago • 0 comments

Scientists have developed CIPDEL, a new GENE EDITING method using Cas12a’s unique DNA-cutting ability to enhance gene editing precision. New dawn to safer medical therapies, improved crops, and more efficient research tools. doi.org/10.1186/s130...

submitted 47 days ago • 2 comments

Cepheid and Oxford Nanopore collaboration to look into infectious disease first nanoporetech.com/news/cepheid...

submitted 53 days ago • 1 comment

A great study where monogenic and polygenic studies converges

submitted 56 days ago • 0 comments

Back in 1962, DNA circles were first spotted in cancer cells. Now, armed with modern molecular biology and genomics tools, researchers are realising that these circles might explain why some cancers are more lethal than others. #ChemSky

submitted 69 days ago • 0 comments

Today for the first time in decades, a new oral antibiotic to treat urinary tract infections was approved by the FDA Gepotidacin is a triazaacenaphthylene that inhibits bacterial DNA replication by targeting DNA gyrase and topoisomerase IV Trade name? BLUJEPA® !!! www.gsk.com/en-gb/media/...

submitted 68 days ago • 3 comments

For the first time, researchers have used the CRISPR gene editor to repair AAT gene in the human body. www.science.org/content/arti...

submitted 70 days ago • 0 comments

Computational biology XKCD!

submitted 76 days ago • 1 comment

One of those truly multiomic studies. Get to see sQTL, eQTL, pQTL, mQTL connect genetic etiology across molecular traits and health outcomes

submitted 89 days ago • 0 comments

RNA xkcd.com/3056

submitted 95 days ago • 159 comments

Synthetic biologists discuss with Nature why it’s so hard to write a genome. “We underestimated how complex biology is.” 🧪 🧬

submitted 98 days ago • 1 comment

SBX technology utilizes a proprietary biochemical conversion process to expand and encode the sequence of a DNA template into an Xpandomer molecule.

submitted 101 days ago • 0 comments

#RareDiseaseDay (coming up on Friday, February 28, 2025) is a day dedicated to raise awareness of rare diseases and the people they affect. Tune in to this amazing podcast series that delves into the science behind mapping variants in diseases and rare diseases. www.varianteffect.org/podcast

submitted 106 days ago • 0 comments

Simultaneous single-cell CRISPR, RNA, and ATAC-seq enables multiomic CRISPR screens to identify gene regulatory relationships www.biorxiv.org/content/10.1...

submitted 109 days ago • 0 comments

CZI is partnering with an initial cohort of experts in the single-cell field and developers of lifescieence tech. This partnership prioritizes data generation with initial data sets including organisms such as mouse, zebrafish, and primary human cell models. www.prnewswire.com/news-release...

submitted 115 days ago • 0 comments

Applying LLMs to biomedical research today can go one of two ways: we either use a closed-source web app, or we get coding ourselves. Many researchers lack training for the latter, so their only choice is the former. We want to change that. www.nature.com/articles/s41...

submitted 117 days ago • 2 comments

Check out my recent talk on dimensionality reduction, where I try to lay out my thoughts on the topic: youtu.be/AuJzMnH78wM?...

submitted 118 days ago • 1 comment

Geneticist Sir Paul Nurse on the amazing breakthroughs that followed the discovery of DNA - and how it directly impacted his own family. www.bbc.com/videos/cg4yy...

submitted 121 days ago • 1 comment

This is a real instance of dissecting existing data to derive new insights Great work by European Molecular Biology Lab The temporal profiles retrospectively constructed for novel drug targets approved over the past two decades suggest the importance of genetic support for clinical progression

submitted 124 days ago • 0 comments

Ensembl is 25! 🥳 Join us in celebrating our silver birthday by trying out our new browser - beta.ensembl.org 🎂 Silver carp 🩶🐟 and silvery gibbon 🩶🦧 genomes await!

submitted 125 days ago • 2 comments

Metagenome-informed metaproteomics of the human gut microbiome, host, and dietary exposome uncovers signatures of health and inflammatory bowel disease www.cell.com/cell/abstrac...

submitted 131 days ago • 0 comments

And now including our press release @radboudumc.bsky.social www.radboudumc.nl/en/news-item...

submitted 139 days ago • 2 comments

IQVIA, Illumina, Mayo Clinic and Arc Institute Harness NVIDIA AI and Accelerated Computing to Transform $10 Trillion Healthcare and Life Sciences Industry nvidianews.nvidia.com/news/nvidia-...

submitted 139 days ago • 0 comments

Why focus on genomic research in Africa? Despite 99% of human evolutionary history having occurred in Africa and the majority of genetic diversity present in people of African descent, less than 3% of global genomic datasets come from individuals of African origin. www.roche.com/stories/afri...

submitted 147 days ago • 0 comments

Wonderful to see out of 50 drugs approved by @fda.gov in 2024, nearly 20 drugs are for blood and cancer diagnosis! It is promising news for our patients. Applaud the focus on cancer research by industry and academia! @oncoalert.bsky.social

submitted 147 days ago • 0 comments

Great list! Love seeing progress in cancer, preventing HIV, and CAR-T in the @statnews.com article. By @matthewherper.bsky.social apple.news/ArmBm3oYRT1G...

submitted 151 days ago • 0 comments

Who among them received two Nobel Prizes? Which individual was the oldest recipient of the Nobel Prize? How many female Nobel laureates have there ever been? Finally...What letter did most of their name begin with, A or B? www.nature.com/immersive/d4...

submitted 156 days ago • 0 comments

Ok people. I’m drawing silhouettes this afternoon. If you have a paper coming up and you are in need of a #silhouette please let me know and I will have it ready today. As always I upload all my silhouettes to phylopic.org I also have tutorials on how to put a silhouette in a plot in R.

submitted 157 days ago • 18 comments

Surprise, surprise! 😳 This raises an important question… How will our @naturemethods 2024 Method of the Year, #SpatialProteomics, will tackle this before it becomes a potential pitfall? Why Bax detection in >1400 publications might be flawed | Cell Death & Disease www.nature.com/articles/s41...

submitted 157 days ago • 0 comments

I am so incredibly excited to announce that we made the cover of Genome Research! Check out our work on diet evolution across mammals in the latest issue! @genomeresearch.bsky.social @eepuckett.bsky.social @sorrywm.bsky.social

submitted 160 days ago • 0 comments

Check EpiGePT, a breakthrough #Transformer model for human #epigenomics. By using #3Dgenome data & #transcriptionfactor activities, it outshines current models in predicting context-specific signals. A game-changer for unseen cellular contexts! PMID:39696471, Genome Biol 2024 doi.org/10.1186/s130...

submitted 159 days ago • 0 comments

We're excited to announce the beta release of the Apollo 3 Genome Annotation Editor! Apollo provides a flexible and modern interface for interacting with your genome annotations. See our blog post for several ways you can try out Apollo. apollo.jbrowse.org/blog/2024/12...

submitted 164 days ago • 1 comment

Very cool paper. Something I have always been curious about is the extent to which rare burden trait-specific genes are themselves regulators of pleiotropic genes. I.e. the genes on the bottom are TFs for the variants on the top.

submitted 165 days ago • 2 comments

What a cell does depends on its location. Experiments like single cell sequencing strip away signs of where a cell was in its original organ or tissue. New spatial -omics techniques collect in-depth molecular data from cells while retaining that spatial information. Learn more: youtu.be/izhZ9VB1jRM

submitted 173 days ago • 0 comments

Once again, careful scientific investigation demonstrates that, unlike soda or sweet spreads, ice cream and chocolate are good for you. @talyarkoni.com www.frontiersin.org/journals/pub...

submitted 170 days ago • 0 comments