ichikawa-lab.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Latest preprint from the lab, many years in the making! By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase. This could have big implications for our understanding of viral replication & assembly (🧵) www.biorxiv.org/content/10.1...

submitted 6 days ago • 8 comments

Daniel's paper is now published in @jcellsci.bsky.social, great experience with @reviewcommons.org 😀 Want to know everything tubulin assembly in trypanosome flagella and other microtubules? Here is the link: journals.biologists.com/jcs/article/...

submitted 12 days ago • 1 comment

SARS-CoV-2 entry captured: Cryo-ET reveals fusion intermediates of spike protein during membrane fusion, bridging stable pre- and postfusion states. PMID:40461447, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-60406-z #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

submitted 20 days ago • 0 comments

🇨🇦🚨Job Alert🚨🇨🇦 Canada Excellence Research Chair (C$5 or C$10M, 8 yr budget) U Toronto, Dept of Biochem/LabMedPath Was just told they're looking for a structural biologist using cryoEM (related to infectious disease?) Are you an established PI ready to move to 🇨🇦? research.utoronto.ca/funding-oppo...

submitted 24 days ago • 1 comment

We were thrilled to welcome Dr. Lisa Heinke @lisaheinke.bsky.social, a Senior Editor at Nature Reviews Molecular Cell Biology, to Fudan University! She gave a fantastic talk on the editorial process and career paths as a scientific editor! Thank you, Lisa!

submitted 29 days ago • 0 comments

ICYMI: New online: Multiple steps of dynein activation by Lis1 visualized by cryo-EM

submitted 31 days ago • 0 comments

ICYMI: New Online! Molecular machineries shaping the mitochondrial inner membrane

submitted 38 days ago • 0 comments

Scientific Editor position (absence cover) - apply now and join our team!

submitted 38 days ago • 0 comments

📣 🥳 🧑‍💻 Our department is hiring: Tenure-Track Assistant Professor / Associate Professor in Bioinformatics at Aarhus University, Denmark Deadline June 1st Thanks for sharing! mbg.au.dk/en/news-and-...

submitted 39 days ago • 0 comments

Our meeting at beautiful Dushu Lake near Suzhou ended yesterday after many great talks. I really enjoyed learning about cell death and immunity pathways associated with it! Now I’m on my way to Fudan University for a lab visit and seminar, kindly hosted by @ichikawa-lab.bsky.social 🙌🏻

submitted 39 days ago • 0 comments

🌏 Make your mark in Melbourne! 🌏 We are looking for innovative researchers to join WEHI as Laboratory Heads and help lead the next wave of biomedical discovery. For more information and to apply 👇

submitted 40 days ago • 0 comments

We're hiring 📢 The Research Cross-Journal Editorial Team @natureportfolio.nature.com has not one, but TWO openings for Associate or Senior Editors in Life Sciences. If you fancy a career in editorial, we'd love to hear from you 😀

submitted 47 days ago • 1 comment

Sweeeeeet, the corresponding author is called 'Zuker' affiliated with the Zuckerman Institute!!!! 🧪 What else could they have worked on?!? 😂 First structures of human sweet receptor are mindblowingly beautiful!! 🍰🍭😍 And very inspired paper title... www.cell.com/cell/fulltex...

submitted 47 days ago • 0 comments

While I generally think the CERC program is not an efficient use of Canada's research $, this is an excellent opportunity for a senior investigator to relocate to 🇨🇦 Western University (London, ON)

submitted 50 days ago • 0 comments

The one and only @agwrobel.bsky.social is hiring for his new lab at Oxford. Structural biology and biochemistry of viruses. More at www.wrobel-lab.org

submitted 50 days ago • 0 comments

My dept in London at Imperial (Bioengineering) is recruiting a group leader at Professor level 🧑‍🎓 Please RT. It's a great place with world-class expertise in all sorts of biomedical & biological engineering topics like synthetic biology. It's also not in the USA. www.imperial.ac.uk/jobs/search-...

submitted 53 days ago • 0 comments

Postdoc position in my lab: investigating how the microtubule motor protein dynein-2 works in cilia. Here's dynein-2 at work translocating microtubules - how is this activity regulated? How does dynein-2 malfunction in disease? Find out more and apply: my.corehr.com/pls/uoxrecru...

submitted 55 days ago • 2 comments

How do cells keep their cilia “clean” and functional? Our new study uncovers a conserved mechanism for retrieving polyubiquitinated proteins from #cilia – a process essential for cellular signaling and health. #cellbiology #ciliopathy #ubiquitin #IFT 🧵👇 1/n

submitted 56 days ago • 2 comments

Just posted on bioRxiv! We reveal the structure of the MurJ/LysM (JM) complex. A small phage protein, LysM (37 residues), binds to MurJ like a wedge and freezes its motion. www.biorxiv.org/content/10.1...

submitted 58 days ago • 0 comments

🦠🧠 MemBrain update! 🧠🦠 We’ve updated our preprint! It now covers the full MemBrain v2 pipeline for end-to-end membrane analysis in #CryoET: segmentation, particle picking, and spatial statistics. 🔗 Preprint: doi.org/10.1101/2024... 🔗 Code: github.com/CellArchLab/... 🧵(1/6) #TeamTomo

submitted 60 days ago • 2 comments

Finally in peer-reviewed form: Mapping the ultrastructural topology of the corynebacterial cell surface. @bupbuse.bsky.social @vikramalva.bsky.social Please also see concurrent beautiful work from @adriasogues.bsky.social and Han Remaut.

submitted 62 days ago • 4 comments

📢 The University of Frankfurt (Germany) is hiring a Full Professor in Organic Synthesis -->Cutting-edge research in an open, collaborative environment? Check out the call and join one of Germany’s leading research universities. #AcademicJobs #FacultyPosition www.nature.com/naturecareer...

submitted 62 days ago • 0 comments

New online: The mechanochemical cycle of reactive full-length human dynein 1

submitted 63 days ago • 0 comments

Nature research paper: Structure of the ATP-driven methyl-coenzyme M reductase activation complex https://go.nature.com/4jhc50h

submitted 66 days ago • 1 comment

Our PhD student Louis Romette is optimizing long-term live-cell imaging. He just casually dropped this 65-hour movie of a growing neuron (div 3 to 6) with knocked-in actin 🔥🕶️ #realtimemicroscopy

submitted 68 days ago • 14 comments

Maybe the opportunity of your life, become the Head of the wonderful Department of Biomedical Engineering @unistrathclyde.bsky.social in Glasgow 🏴󠁧󠁢󠁳󠁣󠁴󠁿 : 👉 www.nature.com/naturecareer...

submitted 70 days ago • 0 comments

A week until our 51st @bscb-official.bsky.social @gensocuk.bsky.social @ukcilianetwork.bsky.social UK Cilia and Centrosome Network e-symposium: 15/04/2025 15:00-17:15 BST. Still not registered for the series- join us here: www.eventbrite.co.uk/e/bscb-genso... Free and open to all! /1

submitted 70 days ago • 2 comments

Check out our new study revealing how ATP-independent activator Bpa binds asymmetrically to the Mtb #proteasome — and pinpointing key Bpa residues involved in substrate interaction. 👏 Tatjana v. Rosen, Rafal Zdanowicz & @yasser-elhadeg.bsky.social 🔗 www.nature.com/articles/s41...

submitted 88 days ago • 0 comments

US students. Looking to apply to graduate school? Had an offer rescinded recently? The University of British Columbia in Canada will re-open the application portal in some departments for US students from April 14-18. Details: www.grad.ubc.ca/us-applicant... #ubc #AcademicSky #PhDSky #ScienceSky

submitted 74 days ago • 14 comments

Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social, @marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social 🔗 Preprint here tinyurl.com/3a74uanv

submitted 74 days ago • 12 comments

#CryoSPARC v4.7 is out! 🚀 Featuring a new automatic Micrograph Junk Detector that labels and rejects contaminants, new tools for curating subsets of particles, performance and stability fixes, and more! Full changelog: cryosparc.com/updates #cryoEM

submitted 76 days ago • 1 comment

Tenure track position in Metabolic Disease. Carleton University, Ottawa 🇨🇦

submitted 77 days ago • 0 comments

Young ones. Get thee to Europe.

submitted 78 days ago • 1 comment

Importin-9 and a TPR domain protein MpH drive periodic patterning of ciliary arrays in #Tetrahymena, say Anushi Suwaneththiya Deraniyagala, Wolfgang Maier, Jacek Gaertig @universityofga.bsky.social and colleagues: rupress.org/jcb/article/... #Cilia #Development

submitted 81 days ago • 0 comments

Happy #FluorescenceFriday 🔬🌈 Ex vivo live-cell imaging of photoreceptor cells in mouse retina explants. What are all those green dots? Stay tuned 😉!

submitted 81 days ago • 3 comments

Structural basis of a phosphotransferase system xylose transporter https://www.biorxiv.org/content/10.1101/2025.04.02.646771v1

submitted 81 days ago • 0 comments

Are you an established (”distinguished”) researcher outside Europe? Thinking of moving here for some reason? Grant opportunity just dropped: www.vr.se/english/appl...

submitted 84 days ago • 0 comments

The number of new grants handed out by the National Science Foundation since President Donald Trump took office has fallen by nearly 50% compared with the same 2-month period 1 year ago. scim.ag/42dCJjc

submitted 84 days ago • 3 comments

We are looking for a PhD student/Postdoc to develop methods of cryo-ET and/or study the structure and function of membrane proteins. Great team at the MDC in Berlin. It's a broad call, please apply and share! jobrxiv.org/job/max-delb...

submitted 88 days ago • 0 comments

Exhausted at the thought of having to resubmit your paper to a new journal after rejection? 🙁 Did you know you can transfer your paper+reviewers reports from any journal to any of @biologists.bsky.social journals, and get a quick decision, from editors who are working biologists 😃 #biologists100

submitted 90 days ago • 0 comments

Universities in France and elsewhere in Europe have begun recruiting researchers who lost their jobs in the Trump administration’s cost-cutting efforts, or are anxious over perceived threats to academic freedom.

submitted 91 days ago • 69 comments

The unexpected structure & dynamics of #vimentin networks. Komal Bhattacharyya & Stefan Klumpp discuss new work from Renganathan et al. (rupress.org/jcb/article/...) that provides unprecedented detail of the intermediate filament network in cells rupress.org/jcb/article/... #Cytoskeleton

submitted 91 days ago • 0 comments

Nuclear F-actin in unperturbed Plasmodium falciparum using electron cryo-tomography from Josie L Ferreira lab - WOW!! www.embopress.org/doi/full/10....

submitted 91 days ago • 0 comments

Nanopore technology might be able to sequence proteins soon! Read about the road ahead in this exciting Perspective rdcu.be/edWPi in @naturebiotech.bsky.social

submitted 98 days ago • 2 comments

Given the current situation, is there a possibility that Dynein2025 will allow online participation..?

submitted 94 days ago • 1 comment

I'm super happy that our story is now published! 📖 www.science.org/doi/10.1126/... But what changed compared to the original preprint? Also, I feel i should post Movie 1 🎥, that inspired the cover. Back when I did the original bluesky thread, movies were not available.

submitted 95 days ago • 7 comments

Asgard archaea have actin - but what about microtubules? Where do they come from? 🧐 Our new paper www.cell.com/cell/fulltex... by @xujwet.bsky.social & @florianwollweber.bsky.social, in collaboration with the Schleper & Wieczorek labs, describes tiny Asgard microtubules! #TeamTomo #ArchaeaSky 1/6

submitted 95 days ago • 8 comments

We're on the cover of @science.org this week. Awesome work by @florentwaltz.bsky.social. #CryoET is reaching crazy resolutions inside cells, and this is just the beginning. Fantastic interpretation of the proton motive force by @verenaresch.bsky.social. Always a pleasure making #SciArt with you!🧪🧶🧬🌾

submitted 96 days ago • 16 comments