jgcastillo.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Happy to say that my 2nd PhD paper is finally out in @cp-immunity.bsky.social!! One more to go! Thread coming later today!

submitted 1 day ago • 0 comments

NIH funding to HMS, including for ImmGen, has been terminated. This threatens tools used by 10,000+ immunologists globally. Please email support for ImmGen’s value to you to Immgen(at)gmail.com, your Senator (US), or US Embassy (abroad). Thanks The ImmGen Team #immgen #supportScience #NIHfunding

submitted 2 days ago • 0 comments

Succinate drives gut inflammation by promoting FOXP3 degradation through a molecular switch @natimmunol.nature.com www.nature.com/articles/s41... www.nature.com/articles/s41...

submitted 4 days ago • 0 comments

We are also raising money to support undergrads at UCSF this summer! Help me, @neuronush.bsky.social and @quexarce.bsky.social buy ice cream and pizza for our little community of undergraduate researchers! 20% of sales for the rest of the month will go towards our programs!!!

submitted 8 days ago • 4 comments

Zhang, Celis-Gutierrez, Malissen, Malissen et al. @ciml.bsky.social‬ demonstrate that the expression of a mutated CARMIL2 protein in CD28-deficient mice induces most of the developmental and functional consequences known to result from CD28 costimulation rupress.org/jem/article/...

submitted 15 days ago • 0 comments

I always love commencement time. So much to celebrate and we get to wear our wizard robes! Congratulations to all the graduates! 👏 🤩

submitted 13 days ago • 1 comment

Sang-Nee Tan et al. show that regulatory T cells converted from Th1 cells in tumors suppress #cancer immunity via CD39. rupress.org/jem/article/... 📘 In our Clinical #Immunology Collection: rupress.org/jem/collecti... #FOCIS2025

submitted 17 days ago • 0 comments

Was happy to provide a little excerpt, along with others, about the recent @hhmi.org Hanna Grey decision last week as an applicant and a former Gilliam Fellow that knows how important these fellowships are for early career scientists with limited resources.

submitted 17 days ago • 0 comments

Inhibition of IL2Rβ-dependent STAT5 activity supports T-cell stemness and augments antitumor efficacy of CD8+ T cells by preventing T-cell exhaustion www.biorxiv.org/content/10.1...

submitted 20 days ago • 0 comments

I honestly feel incredibly aggrieved for those like me who learned they are losing their NIH funding, but also for everyone who gave their all to their application only for it to be dismissed and not even given the time of day.

submitted 20 days ago • 0 comments

Word on the street is that HHMI is ending its highly impactful Hanna Gray Fellows Program. If true, its another extremely disappointing capitulation by our leading biomedical philanthropy www.hhmi.org/programs/han...

submitted 21 days ago • 3 comments

Heartbroken to hear that the @hhmi.org Hanna Grey fellowship competition is being cancelled this year. I poured so much work and creativity into this app and am very grateful for everyone who helped me revise. It is such a difficult time to be a young scientist.

submitted 21 days ago • 7 comments

Deeply disappointed in HHMI today. Others and I worked hard to submit these applications and to have them be pulled months after their submission, super disheartening…

submitted 21 days ago • 0 comments

To reduce the potential for immunogenicity, Shukla et al. screened a library of fully human anti-CD19 scFvs for expression, functionality, and tonic signaling. bit.ly/4j7Vw66

submitted 21 days ago • 0 comments

Our latest research is now available as a pre-print at BioRxiv. We show that the immune checkpoint receptor TIGIT cannot signal in T cells without simultaneous TCR stimulation. #ImmunoSky www.biorxiv.org/content/10.1...

submitted 23 days ago • 2 comments

More outstanding work from the @santoshvardhana.bsky.social lab, second preprint dropped this week! Take time to read the bluetorial, including brilliant application of #clickchemistry 👏

submitted 22 days ago • 0 comments

New lab preprint! Unveiling the Molecular Architecture of T Cells and Immune Synapses with Cryo-Expansion Microscopy (Cryo-ExM). A fantastic collaboration with Dr. Benita Wolf. Congratulations to all authors, especially Florent Lemaitre, for leading this amazing work! www.biorxiv.org/content/10.1...

submitted 44 days ago • 3 comments

Love to see a story from start to finish! Great job Alex!! 🙂

submitted 22 days ago • 0 comments

Excited to share our latest review! We explore how imaging advances understanding of antigen processing and presentation in cancer, key processes shaping T cell responses and immunotherapy outcomes. We highlight imaging tools, biomarkers, and challenges for clinical translation.

submitted 23 days ago • 0 comments

#Preprint alert! Kevin Chen, a brilliant @mskcancercenter.bsky.social GSK graduate student and NCI F99/K00 awardee, identifies a novel, post-transcriptional checkpoint on intratumoral T cell function: www.biorxiv.org/content/10.1...

submitted 24 days ago • 2 comments

1/ A long standing paradox in my mind (from always seeing immune "strength" or reactivity drawn as a spectrum from immunodeficiency to autoimmunity) was resolved this year at #AAI #Immunology2025. WHY do SO many people have both simultaneously? Each infection brings risk of developing autoimmunity!!

submitted 26 days ago • 2 comments

Our team (hsph.harvard.edu/research/ube...) is excited to have contributed to the intranodal in vivo testing of the remarkable new compound, Fentomycin-1. Congrats to team Rodriguez et al. for the implications of this work in targeting ferroptosis in cancer. Check it out here!

submitted 30 days ago • 3 comments

Excited to see this out in @science.org today!! www.science.org/doi/10.1126/...

submitted 36 days ago • 6 comments

Curious what your favorite gene might do in T cells? We made #FITdb to enable an intuitive integrated view of functional requirements of various human and mouse T cell types across diverse contexts. Want to contribute? reach out! feedback welcomed. Happy exploring! @lji.org

submitted 30 days ago • 0 comments

Reminder: The 1st FASEB #Ferroptosis Meeting is this summer! Spectacular speaker lineup + short talks selected from submitted abstracts. It is going to be awesome! Trainees, newcomers & all interested are welcome! 📅 Abstract deadline: June 1, 2025. shorturl.at/QA6T1

submitted 34 days ago • 0 comments

Deep, Gudjonson, Rudensky et al. identified two distinct differentiation paths for effector and precursor central memory T cells arising from heterogeneous naïve CD4+ T cells. rupress.org/jem/article/... 📘 In JEM #Immunology Collection: rupress.org/jem/collecti... #AAI2025

submitted 33 days ago • 0 comments

We think of Tregs having no PI3K/Akt/mTOR activation or glycolytic switch after CD3/CD28 stimulation. However, TNFR2 costimulation actually induces glycolytic flux via mTORC1, contributing to their suppressive function and stability. www.nature.com/articles/s42... De Kivit et al 2020 🧪⑂

submitted 36 days ago • 0 comments

Multiplexed orthogonal base editing systems introduce different point mutations at two loci simultaneously go.nature.com/3K8Kfn1 rdcu.be/ej7Kz

submitted 36 days ago • 0 comments

Now online! Selective requirement of glycosphingolipid synthesis for natural killer and cytotoxic T cells

submitted 38 days ago • 0 comments

Our review on Protein Synthesis and Metabolism in T cells is out @annualreviews.bsky.social @cantrell-lab.bsky.social Protein Synthesis and Metabolism in T Cells #proteomics #immunometabolism #Tcells www.annualreviews.org/content/jour...

submitted 41 days ago • 0 comments

Tissue-resident memory T cells have high levels of mRNA of proinflammatory cytokines but produce the proteins only upon stimulation. 🧪⑂ The integrated stress response inhibits mRNA translation in these cells, having these cells poised for rapid responses in 🐭 and 🧓. 1/2

submitted 43 days ago • 2 comments

genomebiology.biomedcentral.com/articles/10.... Quite an indictment of some of the current single cell "virtual cell" foundation models. Even for the relatively mundane applications, cell labeling, batch correction etc, they are poor compared to much simpler & cheaper methods.

submitted 47 days ago • 6 comments

The five senses of immunity #immunology

submitted 48 days ago • 0 comments

A new chapter of the Peruvian Genome Project is out! We explored the genetic composition and dynamics of individuals living in urban areas. We analyze genome-wide data from 432 urban individuals across 13 regions of Peru, including 346 newly genotyped! (1/6)

submitted 49 days ago • 1 comment

Liver-targeted allergen immunotherapy rapidly and safely induces antigen‑specific tolerance in a mouse model of allergic asthma, suppressing airway inflammation and reducing IgE levels. A single administration yields long‑lasting protection with minimal side effects. www.science.org/doi/10.1126/...

submitted 50 days ago • 0 comments

CD62L marks a progenitor subset of the progenitor-exhausted CD8 T-cell in mice with chronic LCMV infection and the transcription factor MYB is important for this state. Conditional MYB -/- leads to hyperinflammation, illustrating exhaustion as an adaptive state. doi.org/10.1038/s415... 🧪

submitted 54 days ago • 1 comment

It used to be thought that T-cell priming occurred as single phase. Now we know it takes two. www.science.org/doi/10.1126/... @science.org

submitted 57 days ago • 3 comments

Showcase your research! Submit your poster abstract by April 16 (11:59pm MST) to join speakers @lydiafinley.bsky.social, Ralph J. DeBeradinis, & Keynote Navdeep Chandel. Apply now: keysym.us/KSMetabDev25. Can't attend? Access insights On Demand for 6 months post-conference! #KSMetabDev25 #cellfate

submitted 56 days ago • 0 comments

Integration of biobank-scale genetics and plasma proteomics reveals evidence for causal processes in asthma risk and heterogeneity www.cell.com/cell-genomic...

submitted 59 days ago • 0 comments

Hi everyone, we are petitioning them to reconsider, if you are willing to co-sign our rebuttal because you or your trainees are personally interested in attending such a workshop, please add your name and professional affiliation to the end of the following document! docs.google.com/document/d/1...

submitted 63 days ago • 2 comments