jnb-lab.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

I am delighted that our manuscript 'Staphylococcus haemolyticus is a reservoir of antibiotic resistance genes in the preterm infant gut' is now published. www.tandfonline.com/doi/full/10.... Big thank you to all co-authors, particularly @lisalamberte.bsky.social and @halllab.bsky.social

submitted 8 hours ago • 1 comment

Structure of the virulence-associated Neisseria meningitidis filamentous bacteriophage MDAphi Out in @pnas.org Congrats @janboehning.bsky.social @abultarafder.bsky.social Miles Graham @mathieucoureuil.bsky.social @mrclmb.bsky.social @hopitalnecker.bsky.social www.pnas.org/doi/10.1073/...

submitted 8 hours ago • 1 comment

I'm thrilled and honoured to receive the 2025 Lister Prize, along with seven other fantastic biomedical scientists 🔬🦠🧬 This award will enable us to determine high-resolution structures of viral protein synthesis inside infected cells

submitted 3 days ago • 7 comments

Our new preprint revealing a new mechanism of mitochondrial disease pathophysiology: the accumulation of toxic complex I intermediates bound to complex III www.biorxiv.org/content/10.1...

submitted 4 days ago • 0 comments

🤩 Last week I successfully defended my PhD! It was such a special day, made even better by having friends, family, and colleagues there with me. Thanks for all the support and kind words! Huge thanks to my jury members for the thoughtful feedback and conversations. @soldatilab.bsky.social

submitted 6 days ago • 2 comments

🚨 New preprint! Using U-ExM + in situ cryo-ET, we show how C2CD3 builds an in-to-out radial architecture connecting the distal centriole lumen to its appendages. Great collab with @cellarchlab.com @chgenoud.bsky.social @stearnslab.bsky.social 🙌. #TeamTomo #UExM www.biorxiv.org/content/10.1...

submitted 4 days ago • 0 comments

Our latest preprint is now available doi.org/10.1101/2025...! Led by my postdoc, Luqiang Guo @luqiang.bsky.social, we determined a ~2.4 A resolution structure of the hantavirus glycoprotein tetramer on the surface of VLPs. Also determined structures of dimers of tetramers and Fab-bound tetramers.

submitted 5 days ago • 2 comments

Latest preprint from the lab, many years in the making! By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase. This could have big implications for our understanding of viral replication & assembly (🧵) www.biorxiv.org/content/10.1...

submitted 5 days ago • 8 comments

Proud to share our latest paper. doi.org/10.1016/j.cr... Through the dedication of @glynnca.bsky.social and @cryingem.bsky.social we report a thorough method to image molecular organisation within hippocampus tissue. Structural biology in tissue is well and truly here! @rosfrankinst.bsky.social

submitted 6 days ago • 2 comments

‼️ Save the date! ‼️ Tuberculosis: Understanding the Disease Across Scales Keystone 2026 on March 23-26 in Cape Town, South Africa 🇿🇦 Very excited to organise this meeting with Digby, Bree and Margarida Short Talk Abstract Deadline: Nov. 24, 2025 www.keystonesymposia.org/conferences/...

submitted 7 days ago • 1 comment

GenerationResearch has two fully funded MRes positions (including stipend!) for UK Home students for projects in Chemistry (including structural biology). Applications are due June 19th, and students from underrepresented backgrounds are encouraged to apply. Please share!

submitted 10 days ago • 0 comments

1/x New story - the structure of the Vault cap, at 2.3Å! Matching a beautiful preprint from @sjorsscheres.bsky.social, we show that the cap of the vault particle has C13 symmetry, in contrast to the 39-fold symmetry of the body. Study lead by talented postdoc @huanli00.bsky.social from my group! ⬇️

submitted 11 days ago • 2 comments

We are reviewing the current state of scientific publishing, and we want to hear from researchers on their perceptions of publishing in the current context and how it might develop in future. Complete our short survey now:

submitted 19 days ago • 6 comments

"a fascinating case study on the limits of AI in biology and the harms of current publishing incentives" rachel.fast.ai/posts/2025-0...

submitted 19 days ago • 1 comment

I’m very happy to share my first paper on the effects of AWI interactions and flexibility on SPA data quality! Thank you to everyone on the team 🤩 www.sciencedirect.com/science/arti...

submitted 21 days ago • 3 comments

Phage people: Rich Losick and I are combing the world looking for T4 rIIB mutant FC0 (also known as P13). FC0 was the starting point for Francis Crick's beautiful 1961 paper on the triplet nature of the genetic code. We want to sequence it. Anyone have it in an ancient stock collection?

submitted 22 days ago • 4 comments

Check out our latest preprint! We show that the same antibacterial toxin requires different immunity proteins depending whether it’s intra or extracellular

submitted 22 days ago • 1 comment

🇨🇦🚨Job Alert🚨🇨🇦 Canada Excellence Research Chair (C$5 or C$10M, 8 yr budget) U Toronto, Dept of Biochem/LabMedPath Was just told they're looking for a structural biologist using cryoEM (related to infectious disease?) Are you an established PI ready to move to 🇨🇦? research.utoronto.ca/funding-oppo...

submitted 23 days ago • 1 comment

🔬𝐔𝐊 𝐄𝐮𝐫𝐨-𝐁𝐢𝐨𝐈𝐦𝐚𝐠𝐢𝐧𝐠 𝐍𝐨𝐝𝐞 𝐬𝐞𝐜𝐮𝐫𝐞𝐬 £𝟏.𝟖𝐌 from @ukri.org This will: -Democratise access to cutting-edge biological and biomedical imaging -Support 200+ researchers yearly -Boost open science Thanks to BBSRC and MRC for this major upgrade! 🚀 Congrats to the entire UK Node team 👏 Link in replies⬇️

submitted 24 days ago • 3 comments

Pleased to share my very general review of Photosynthesis now published in Nature Reviews Mol Cell Biol 🌞🌱 rdcu.be/em1lz Hopefully a useful primer for Postgrad and undergrad students

submitted 33 days ago • 0 comments

Proud to share the results of a study that tells us how M. tuberculosis remodels central metabolism in response to iron deficiency. @agnese75.bsky.social @luizcarvalholab.bsky.social www.biorxiv.org/content/10.1...

submitted 41 days ago • 1 comment

Happy to share our latest paper. Result of a great collaboration between @sheinerlab.bsky.social @oninopantsu.bsky.social and Alexander Mühleip’s new group. www.nature.com/articles/s41...

submitted 35 days ago • 4 comments

EtfD links beta oxidation to OxPhos in mycobacteria - recent work suggests that targeting EtfD could shorten #tubeculosis treatment. But how does EtfD work? And how can you assay its activity? In his final PhD manuscript @courbongautier.bsky.social provides answers! www.biorxiv.org/content/10.1...

submitted 38 days ago • 1 comment

Having recently submitted manuscripts to Nature Communications/Science Advances and the like, very surprised to see the data like this published, claiming magnesium interaction. The purported resolution is 2.5 Å doi.org/10.1038/s414...

submitted 39 days ago • 2 comments

1/ Excited to share our latest work on gene transfer agents (GTAs) in Caulobacter crescentus, led by Emma Banks in collaboration with Pavol Bardy and Mai Nguyen from York!!! See a brief thread below. shorturl.at/o6S1w

submitted 45 days ago • 2 comments

"LLM on way to replace doctors" gets published in Nature. meanwhile "LLM judgement not as good as human MDs" gets a spot in "Physical Therapy and Rehabilitation Journal".

submitted 50 days ago • 2 comments

1/5: Over the last few months, I have been working on an update for the #FollowRelionGracefully dashboard, which offers improved real-time job previews for #cryoEM #Relion jobs.

submitted 56 days ago • 2 comments

Honoured and very excited to be a recipient of the AMS Springboard Award 2025. This award will support us in unravelling the complex role of glycans in neurological disorders @unisouthampton.bsky.social 🔬🧠 #Springboard25

submitted 76 days ago • 0 comments

inspiring and relatable talk from @alisterburt.bsky.social #ccpem

submitted 59 days ago • 3 comments

The architecture of membrane structures involved in hepatitis C virus genome replication revealed in close-to-native conditions by cryo-electron tomography www.biorxiv.org/content/10.1101/2025.04.24.650446v1 #cryoEM

submitted 59 days ago • 0 comments

Super excited that this manuscript investigating verapamil potentiation of bedaquiline in M. tuberculosis is now in PNAS!! Great collaborative effort with Lalita Ramakrishnan and her team at the MRC-LMB!! www.pnas.org/doi/10.1073/... @pnas.org @universityofotago.bsky.social

submitted 60 days ago • 0 comments

After years parked at a Polara, I’m excited to share that my PhD work is finally out! We figured out why imaging at liquid helium temperatures wasn’t working—and how to fix it. 🔗 www.pnas.org/doi/10.1073/...

submitted 61 days ago • 2 comments

Welcome @oraxdrf.bsky.social! Following him = news about the latest and greatest in #cryoEM ❄️🔬and #cryoET applications 🙂

submitted 62 days ago • 1 comment

Absolutely stunning images of mycophages attacking a mycobacterial cell

submitted 62 days ago • 0 comments

Hurray, it is finally out! Meet bacteriophage Bxb1 - the subject of my first full-phage cryo-EM study. My structures are beautifully complemented by the Park Lab’s cryo-ET analysis, shedding light on mycobacteriophage structural changes during infection. www.sciencedirect.com/science/arti...

submitted 68 days ago • 5 comments

Geese at York on their way to confront Jamie blaza @jnb-lab.bsky.social about his role in the DUC …luckily its good Friday and we hope to see him feathers intact at the joint BCI user meeting an @ccpem.bsky.social spring symposium next week!

submitted 66 days ago • 1 comment

1) We have a jammed packed agenda for the joint BCI-user meeting and CCPEM spring symposium that starts just after Easter on the 23rd April! ...for those lucky registered attendees there is a difficult choice to be made with 5 parallel sessions!!! @ccpem.bsky.social @diamondlightsource.bsky.social

submitted 69 days ago • 1 comment

Super excited for the arrival of our brand new Lumicks C-Trap in Biology at York @yorkbioimaging.bsky.social, funded by @ukri.org BBSRC. This state-of-the-art optical tweezers / confocal microscope will enable us to probe the dynamics of structured viral RNAs, one molecule at a time 🔆🧬🔆

submitted 68 days ago • 0 comments

Long-chain fatty acids can be carbon sources for pathogens but are also potent antimicrobials. In our latest work, we explored the question of how Mycobacterium tuberculosis avoids getting killed by a preferred carbon source. www.biorxiv.org/content/10.1...

submitted 69 days ago • 0 comments

First time I am seeing holes in my aromatics, collected at #SLAC temalpha #cryoem. Full story hopefully by the end of the summer!

submitted 69 days ago • 0 comments

I started on this around 2006 so only taken 20 years! The project itself started over 30 years ago. Great to finally see the elusive structure.

submitted 74 days ago • 1 comment

Needless bureaucracy and “bullshit jobs” are preventing academics from fulfilling their core creative responsibilities and making clinical research an “impossible task”, a leading neuroscientist has warned. @patrickjack.bsky.social reports #AcademicSky

submitted 74 days ago • 0 comments

Two ERC-funded postdoc positions available in the team - one here and second to follow - please repost! jobs.ncl.ac.uk/job/Newcastl...

submitted 75 days ago • 1 comment