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kasperdhansen.bsky.social
Professor @ JHU, statistical genomics, www.hansenlab.org
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I've seen folks talk about how "in four years" they'll be able to get back to their planned projects and I really don't think that's going to work out. People & projects losing funding now will not be able to hit pause and come back once funding is restored. Hard-won progress & capacity will be lost

I am at StatGen 2025 in Minneapolis. I would be happy to chat with students or postdocs about research or career questions. Send me a DM.

Apparently, transcriptomics is not the only field struggling with overly optimistic results from new deep learning techniques. www.understandingai.org/p/i-got-fool...

I wrote a thing about multivariate normal sampling in #rstats, and why you would be well-advised to prefer mvtnorm::rmvnorm() over MASS::mvrnorm() Now. Let us never speak of this again

"I'm still in shock. I know that there have been political issues around Harvard in recent weeks, but antibiotic resistance isn't one of them." My conversation with Harvard microbiologist @baym.lol, one of many researchers there who just lost millions in fed. grants. www.wbur.org/news/2025/05...

I received a surprising and disturbing request from NIH on Friday. They wrote to cancel a subaward to Hong Kong on one of my grants. (This was disturbing but not surprising.) They also ordered us not to interact with our collaborators in Hong Kong on any work under the award:

I wrote about how we must stand and fight against the threat of eugenics. Fueled by white nationalism and scientific racism, these beliefs are factually wrong and ethically abhorrent. This fight includes supporting efforts to diversify our workforce & science. To stop now would be a deep betrayal.

I miss when the biggest controversy about mRNA was whether it correlated with protein or not.

Schumer needs to go

Tenure clock extensions are a great deal for the institution. Not so much for the faculty member

Really excited to present in this fantastic seminar series this Wednesday. Will be sharing some of the insights we have gained into disease-associated epigenetic changes by studying the Mendelian developmental disorders of the epigenetic machinery.

UC Berkeley researcher pushes AI to the next level by comprehensively simulating the complex behavior of a complete organism.

Switching from internet to zoom phone so campus can save money. With new training, websites etc. How often do campuses think through: "we save $100,000, but use 1.5hrs of prof time with 5,000 profs getting paid $75/hr and.. oh shit we just spent $550K on salary to save $100K" .. I'm guessing never

Super huge congrats to postdoc in our group Bernie Mulvey and co-leads Kristen Maynard & @kasperdhansen.bsky.social on this absolute tour de force paper profiling sex differences in the human hypothalamus. Really important biological insight about gene expression differences in sex-biased disorders.

For #FluorescenceFriday - sneak peek from new preprint coming soon investigating spatially-resolved molecular sex differences in the human hypothalamus - spearheaded by postdoc in our group Bernie Mulvey, and led by Kristen Maynard and @kasperdhansen.bsky.social 🧠🔬🧪

At CSHL for Biological Data Science 2024

We had a great seminar at JHU from David Gorkin (Emory) on mechanisms that link chromatin remodelers (specifically BAF) to developmental disorders. I especially enjoyed how he contrasted - in the fetal mouse brain - the effect of heterozygous (more patient relevant) vs. homozygous LOF.

Read this if you’re interested in epigenome editing.

This whole thread is 🤯 full of great science

For all the new followers here: welcome! Here some recent highlights: (1/4) My eclectic and subjective list of scientific writing tips

Looks interesting!

I'm biased because Chris Lo is a close friend and Kasper Hansen is on my committee, but this will be a great resource for population transcriptomics. Trans-eQTL calling is limited by power with "only" hundreds of samples. This corpus has hundreds of thousands. doi.org/10.1101/2023...