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labwaggoner.bsky.social
Run a research lab focused on innate immune mechanisms governing pathogenesis of disease and on NK-cell based therapies for disease.
3,053 posts 3,058 followers 2,089 following
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Airway epithelial cells from children with wheeze are characterized by altered development and susceptibility to RSV infection science.org/doi/10.1126/...

submitted 5 hours ago • 1 comment

Immune cell infiltration into brain tumor microenvironment is mediated by Rab27-regulated vascular wall integrity www.science.org/doi/10.1126/...

submitted 5 hours ago • 0 comments

An engineered viral protein recruits the LCK kinase to activate STAT5 and sustain T cell functionality in solid tumors @sciimmunology.bsky.social www.science.org/doi/10.1126/...

submitted 5 hours ago • 0 comments

The neutrophil clockwork boosts daytime immunity against bacterial infection @sciimmunology.bsky.social www.science.org/doi/10.1126/...

submitted 5 hours ago • 1 comment

DDX5 super-enhancer promotes vasculogenic mimicry formation and metastasis in nasopharyngeal carcinoma by enhancing ADAM10 transcription @cp-cellrepmed.bsky.social www.cell.com/cell-reports...

submitted 5 hours ago • 0 comments

CyTOF-based peripheral immune profiling accurately detects cervical precancer w/ high diagnostic accuracy, especially in HPV16/18+ women, supporting a non-invasive strategy to improve cervical cancer screening www.cell.com/cell-reports... @cp-cellrepmed.bsky.social

submitted 5 hours ago • 0 comments

What radicalized you?

submitted 1 day ago • 256 comments

Announcing the 2025 Investigators in the Pathogenesis of Infectious Disease www.bwfund.org/news/announc... #bwfpath

submitted 9 hours ago • 0 comments

Secretory IgM regulates gut microbiota homeostasis and metabolism @natmicrobiol.nature.com www.nature.com/articles/s41...

submitted 7 hours ago • 0 comments

Review: Adjusting the scope of NK cells in cancer therapy www.nature.com/articles/s41...

submitted 7 hours ago • 0 comments

CAR-NK’s balancing act: when scFv affinity is not too tight, not too loose… but just right? jitc.bmj.com/content/13/5...

submitted 10 hours ago • 0 comments

A Colony Formation-Based Assay to Evaluate NK Cell Antitumor Responses In Vitro link.springer.com/protocol/10....

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Evaluation of NF-kB Nuclear Translocation in NK Cells by Imaging Multispectral Flow Cytometry as a Marker of Anticancer Immune Activation link.springer.com/protocol/10....

submitted 10 hours ago • 0 comments

Engineered CAR-NK Cells for Cancer Immunotherapy: Lentiviral-Based CAR Transduction of NK-92 Cells link.springer.com/protocol/10....

submitted 10 hours ago • 0 comments

High affinity CD16 polymorphism associated with reduced risk of severe COVID-19 @jci-insight.bsky.social insight.jci.org/articles/vie...

submitted 20 hours ago • 0 comments

Vagal oxytocin receptors are necessary for esophageal motility and function @jci-insight.bsky.social insight.jci.org/articles/vie...

submitted 20 hours ago • 0 comments

Fetoplacental extracellular vesicles deliver conceptus-derived antigens to maternal secondary lymphoid tissues for immune recognition @jci-insight.bsky.social insight.jci.org/articles/vie...

submitted 20 hours ago • 0 comments

Targeting intracellular LMP2 with costimulatory signal–armed antibody-like TCR T cells @jci-insight.bsky.social insight.jci.org/articles/vie...

submitted 20 hours ago • 0 comments

Review @jci-insight.bsky.social: Transcriptional signatures of endothelial cells shape immune responses in cardiopulmonary health and disease insight.jci.org/articles/vie...

submitted 20 hours ago • 0 comments

Sex-chromosome complement and Activin-A shape the therapeutic potential of TNFR2 activation in chronic neuropathic pain during multiple sclerosis @pnas.org www.pnas.org/doi/10.1073/...

submitted 20 hours ago • 0 comments

Antigen mobility regulates the dynamics and precision of antigen capture in the B cell immune synapse @pnas.org @katelynspillane.bsky.social www.pnas.org/doi/10.1073/...

submitted 20 hours ago • 0 comments

Molecular determinants of sialylated IgG anti-inflammatory activity @pnas.org www.pnas.org/doi/10.1073/...

submitted 20 hours ago • 0 comments

Microglia repair the BBB following concussion, but in doing so significantly alter the cellular ultrastructure of the brain milieu @pnas.org www.pnas.org/doi/10.1073/...

submitted 21 hours ago • 0 comments

Macrophages release neuraminidase and cleaved calreticulin for programmed cell removal @pnas.org www.pnas.org/doi/10.1073/...

submitted 21 hours ago • 0 comments

Cross-reactive sarbecovirus antibodies induced by mosaic RBD nanoparticles @pnas.org @bjorkman-lab.bsky.social www.pnas.org/doi/10.1073/...

submitted 21 hours ago • 0 comments

Review: TRIM proteins: A ‘swiss army knife’ of antiviral immunity journals.plos.org/plospathogen...

submitted 21 hours ago • 0 comments

EBV LMP1 subverts IMPDH pathways to drive B-cell oncometabolism journals.plos.org/plospathogen...

submitted 21 hours ago • 0 comments

Rev-RRE activity modulates HIV-1 replication and latency reactivation: Implications for viral persistence and cure strategies journals.plos.org/plospathogen...

submitted 21 hours ago • 0 comments

Fatty acid desaturases link cell metabolism pathways to promote proliferation of EBV-infected B cells journals.plos.org/plospathogen...

submitted 21 hours ago • 0 comments

A CARMIL2 gain-of-function mutation suffices to trigger most CD28 costimulatory functions in vivo rupress.org/jem/article/... @jem.org

submitted 21 hours ago • 0 comments

Gut dysbiosis from high-salt diet promotes glioma via propionate-mediated TGF-β activation @jem.org rupress.org/jem/article/...

submitted 21 hours ago • 0 comments

Preprint: Sentinel Tregs reinforce immune surveillance in the CNS www.researchsquare.com/article/rs-6...

submitted 21 hours ago • 0 comments

Glioma-neuronal circuit remodeling induces regional immunosuppression @natcomms.nature.com www.nature.com/articles/s41...

submitted 21 hours ago • 0 comments

CellLENS enables cross-domain information fusion for enhanced cell population delineation in single-cell spatial omics data @natimmunol.nature.com @zongmingma.bsky.social @garrypnolan.bsky.social @shaleklab.bsky.social www.nature.com/articles/s41...

submitted 21 hours ago • 0 comments

Comparative duration of neutralizing responses and protections of COVID-19 vaccination and correlates of protection @natcomms.nature.com www.nature.com/articles/s41...

submitted 21 hours ago • 0 comments

Neutrophils secrete exosome-associated DNA to resolve sterile acute inflammation @natcellbio.nature.com www.nature.com/articles/s41...

submitted 21 hours ago • 0 comments

FcRn-silencing of IL-12Fc prevents toxicity of local IL-12 therapy and prolongs survival in experimental glioblastoma @natcomms.nature.com www.nature.com/articles/s41...

submitted 21 hours ago • 0 comments

Cell trajectory modulation: rapid microfluidic biophysical profiling of CAR T cell functional phenotypes @natcomms.nature.com www.nature.com/articles/s41...

submitted 21 hours ago • 0 comments

Tumor antigens preferentially derive from unmutated genomic sequences in melanoma and non-small cell lung cancer @natcancer.nature.com www.nature.com/articles/s43...

submitted 21 hours ago • 0 comments

NIH killed grants on orders from Elon Musk’s DOGE www.nature.com/articles/d41... @maxkozlov.bsky.social @nature.com

submitted 21 hours ago • 0 comments

Autophagy is an upstream mediator of chromatin dynamics in normal and autoimmune germinal center B cells www.jci.org/articles/vie... @jclinical-invest.bsky.social

submitted 21 hours ago • 0 comments

Myeloid cell genome-wide screen identifies variants associated with Mycobacterium tuberculosis-induced cytokine transcriptional responses @jclinical-invest.bsky.social www.jci.org/articles/vie...

submitted 21 hours ago • 0 comments

Silencing translation of specific mitochondrial mRNAs in living human cells by delivering synthetic peptide-morpholino chimeras @science.org ‪@luisdcruzz.bsky.social‬ www.science.org/doi/10.1126/...

submitted 1 day ago • 0 comments

Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense www.science.org/doi/10.1126/... @science.org @kuchroolab.bsky.social @thexavierlab.bsky.social

submitted 1 day ago • 0 comments

Cross-species tropism of AAV.CPP.16 in the respiratory tract and its gene therapies against pulmonary fibrosis and viral infection @cp-cellrepmed.bsky.social www.cell.com/cell-reports...

submitted 1 day ago • 1 comment

Zero-distance photo-crosslinking reveals direct protein-DNA interactions in living cells, enabling quantitative analysis of the DNA-interacting proteome on a timescale of minutes with single-amino-acid resolution www.cell.com/cell/fulltex... @cellcellpress.bsky.social

submitted 1 day ago • 0 comments

Near-infrared spatiotemporal color vision in humans enabled by upconversion contact lenses @cellcellpress.bsky.social www.cell.com/cell/fulltex...

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A searchable atlas of pathogen-sensitive lncRNA networks in human macrophages @natcomms.nature.com www.nature.com/articles/s41...

submitted 1 day ago • 1 comment

Review @natimmunol.nature.com Intestinal neuron-associated macrophages in health and disease nature.com/articles/s41...

submitted 1 day ago • 0 comments

Human monoclonal antibodies isolated from meningococcus B vaccinees enabled identification of gonococcal antigens responsible for cross-protection www.science.org/doi/10.1126/...

submitted 2 days ago • 0 comments