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laureloldach.bsky.social
Biochemistry & instrumentation reporter at Chemical & Engineering News. Signal: Laurel_Oldach.07
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Heartbreaking, important reporting. wapo.st/3GWKK5k

“With the Trump administration, there’s so many different things all at once,” says Zach Weinberg, CEO of biotech investment firm Curie.Bio. “Come next week, I’m sure there’ll be a whole new set of facts.” Chaos ably chronicled by @rowanwalrath.bsky.social today: cen.acs.org/pharmaceutic...

Today marks my 22nd work anniversary at @cenmag.bsky.social. My colleague @rowanwalrath.bsky.social points out that copper is the traditional gift for 22nd wedding anniversaries, so I thought I'd celebrate by posting this photo of the copper ball Barry Sharpless gave me.

Does your lab have experience working with AI research agents? Would you like to talk about where they fly and where they falter, for a story in C&EN? If so, hit me up - here, at [email protected], or on Signal (Laurel_Oldach.07)

Two excellent pieces of news about @cenmag.bsky.social reporters and their stories: First up, Priyanka Runwal's excellent article on efforts to treat sickle cell disease in India has won a AAJA 2025 Journalism Excellence Award. You can read that story here: cen.acs.org/pharmaceutic...

The same day this story goes live trying to work out what might happen to the drug approvals process, Biohaven became the latest firm to announce a pushed back PDUFA date ir.biohaven.com/news-release...

Hassan grills RFK Jr about HHS still employs David Geier and he *IS NOT* happy about her line of questioning, which he calls "defamatory"

Maybe someone needs to say this out loud, but computers can't model the physiology of a living organism because we don't know how many of the parts of an organism work, which is uhhh... why we do the research with the animal models?

Gang, do we reckon this is a sugar sweetened beverage? I can't tell whether we have an Arnold Palmer or a coffee on our hands

Things are changing so fast at the FDA that when I emailed a trade group for comment on a policy announced yesterday morning, they sent me an answer about the new policy from the day before. Here's a humble attempt to tally up the way these changes might affect drug dev: cen.acs.org/pharmaceutic...

Although temporarily paused by a court order, NSF's restructuring plans have many worried about the agency's future. “The entire landscape of American science, research, and engineering are under heavy attack,” one NSF employee says. cen.acs.org/policy/resea...

Hive mind, please help: there's a biohacker artist type I'm sure I used to follow on Twitter, but maybe not since the diaspora. He had an etsy shop where he sold interesting bioengineered houseplants - and maybe GFP-expressing bacteria, until Etsy cracked down?? What is this guy's name?

Friday timeline cleanse: the chemistry of chemosensation in this year's #DanceYourPhD winner! Featuring me, TRP channels, and Finnish chemist Sulo Roukka and his lab coat/sequinned tops/BRIGHT RED TIGHTS brigade. www.youtube.com/watch?v=V2mf...

Don't give up the book! www.wsj.com/us-news/educ...

👀 On our radar: Cuts hit #FDA program that monitors risky meds 💬 “There’s a handful of people desperately keeping the lights on,” says one fired employee. ✍️ @laureloldach.bsky.social, @cenmag.bsky.social

@laureloldach.bsky.social, @fmorningstar.bsky.social, Britt Erickson and I wrote about the Trump admin's proposed cuts to science agencies for FY26. Cuts range from ~24% at NASA to ~55% at the NSF and the EPA: cen.acs.org/policy/resea...

"Every day brings new reports of people fired, grants cancelled, funding held up, entire programs and sites and agencies under siege. I could write nearly full-time around here while just chasing after this news, but to what end? Regular readers already know what I think, new ones would be ...

well.

The average American has 3 friends

There are 77 currently-approved drugs in the US that can only be prescribed with extra care and precautions, because their risks might outweigh their benefit to patients. Pharmacists can't get updated info about how to dispense some of these drugs after the FDA RIF. cen.acs.org/safety/drug-...

Really important coverage from @science.org of all that's gone down at NIH since 1/20: www.science.org/content/arti...

As far as I can tell - and I would REALLY like to be wrong about this; colleagues? - all media requests for absolutely anything related to FDA, NIH and the rest of HHS are being funneled to one person's email inbox right now.

Let's discuss one of the *Great Philosophical Questions* people have been asking since the beginning of time: Why does my Tupperware get stained by tomato sauce (and what can I do about it)? There's some science 🧪 in here, I promise.

Modality profusion: There are more and more flavors of molecules in clinical or preclinical investigation. How do drug hunters choose between modalities to minimize risk and optimize their chance of developing a successful new drug? cen.acs.org/pharmaceutic...

Science advocates are pushing hard against the Trump administration's actions. But better leadership and more public engagement are needed to make a difference in this unprecedented political climate. cen.acs.org/policy/Scien... #ChemSky #Science #AcademicSky #SciSky

Leaked details on proposed HHS reorg: insidemedicine.substack.com/p/scoop-leak...

Important coverage if you like NIH, CDC, FDA, or generally not dying of preventable causes: www.washingtonpost.com/health/2025/...

"I will no longer be able to continue teaching." Hyeongseon Jeon, an assistant professor at the University of Houston, said he had his foreign visa unexpectedly terminated and now must return to Korea immediately. www.houstonchronicle.com/news/houston...

There is no good time for bad news and today is no different than any day in our recent time. Nevertheless, I write this thread to chemistry faculty job seekers in the United States. #chemjobs #facultychemjobs #chemsky 🧪⚗️

In case you were wondering, "what's the mouse behavioral assay for hallucination?" I'm sorry to tell you that it sounds nowhere near as much fun to watch as marble-burying or the social food preference test. But @bethanyhalford.bsky.social has the molecular deets. cen.acs.org/pharmaceutic...

I will keep posting about this because I want people to know it continues, and it is a lot more than the individual cases we see in the news. >1000 students at 170+ universities across 43 states now. Thank you @insidehighered.com and @amowreader.com www.insidehighered.com/news/global/...

US students. Looking to apply to graduate school? Had an offer rescinded recently? The University of British Columbia in Canada will re-open the application portal in some departments for US students from April 14-18. Details: www.grad.ubc.ca/us-applicant... #ubc #AcademicSky #PhDSky #ScienceSky

If you haven't already had enough of so-called dire wolves, I do think considering how this story blew up is of interest. Namely, how did at least three long detail-rich feature stories about the so-called dire wolves drop on the same day? And what were they missing thebulletin.org/2025/04/dire...