lindorfflarsen.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Basically the @elife.bsky.social model?

submitted 7 hours ago • 1 comment

Excited to share our BICePs manuscript now out in #JCTC @acs.org – congrats Rob Raddi! doi.org/10.1021/acs....

submitted 1 day ago • 1 comment

How the hell are we supposed to predict this stuff?? #compchem

submitted 4 days ago • 4 comments

If you're at the @proteinsociety.bsky.social annual symposium, make sure to go listen to @mcagiada.bsky.social's talk at 14:30 today on Predicting Absolute Protein Folding Stability Using Generative Models

submitted 4 days ago • 1 comment

Magnetic Stirring May Cause Irreproducible Results in Chemical Reactions doi.org/10.1021/jacs...

submitted 4 days ago • 1 comment

Wonderful to be back in Cambridge for a PhD viva Thanks @rcollepardo.bsky.social and Aleks Reinhardt for inviting me and for letting me stay at Trinity while my old college St John’s was having their May Ball

submitted 4 days ago • 2 comments

How might a quantum computer be used to understand and quantify molecular recognition? In this new interdisciplinary study we bridge from quantum algorithms via quantum chemistry and machine-learning potentials to biomolecular free-energy calculations to explore this problem doi.org/10.48550/arX...

submitted 4 days ago • 0 comments

If quantum computers are to deliver benefit to biochemistry, they are not going to work in isolation. With FreeQuantum we provide, implement and demonstrate a computational pipeline for computing free energies of biomolecular systems. It is quantum-ready! arxiv.org/abs/2506.20587

submitted 4 days ago • 0 comments

New €94M research centre for protein design will open at the University of Copenhagen and be led by Dek Woolfson Funded by the Novo Nordisk Foundation, the centre will operate across the Departments of Biology and & Drug Design and Pharmacology novonordiskfonden.dk/en/news/new-...

submitted 5 days ago • 0 comments

From plastic to painkiller A biocompatible Lossen rearrangement in Escherichia coli doi.org/10.1038/s415...

submitted 6 days ago • 2 comments

Iterative in vivo cut‘n’paste of chromosomal loci in Escherichia coli K-12 using synthetic DNA doi.org/10.1101/2025...

submitted 7 days ago • 0 comments

TuberKiller 🤩 🧫🦠❄️🔬 #scicomm

submitted 8 days ago • 0 comments

I saw Tanja talk about this interesting work in Copenhagen a few weeks ago. Do stress condensates act as a precursor to amyloid fibrils or, on the contrary, a diversion from them? It seems the latter. www.cell.com/molecular-ce...

submitted 25 days ago • 0 comments

New paper out from the Mittag lab: www.biorxiv.org/content/10.1... New adventures in understanding structure and function of SPOP, which involve donuts! 🍩 Congratulations to first authors Matt Cuneo, Ömer Güllülü and Mohamed-Raafet Ammar, and all other authors!

submitted 9 days ago • 1 comment

Small angel X-ray scattering

submitted 10 days ago • 0 comments

Just finished two days with 30 orals exams where the students present different papers on integrative structural biology One interesting observation is that many students present the story in the same “chronological” way as in the paper even when we this storyline is often somewhat artificial

submitted 11 days ago • 1 comment

Screening de novo designed protein binders in unpurified lysate using flow induced dispersion analysis https://www.biorxiv.org/content/10.1101/2025.06.17.660127v1

submitted 12 days ago • 0 comments

Sequence-based prediction of condensate composition reveals that specificity can emerge from multivalent interactions among disordered regions https://www.biorxiv.org/content/10.1101/2025.06.13.659429v1

submitted 12 days ago • 0 comments

Does crossing the pond affect crystal quality? No!

submitted 13 days ago • 1 comment

Due to the high level of interest, we have decided to extend the deadline to 10 July. That means there’s still time to apply for our @embo.org course at meetings.embo.org/event/25-bio... !!

submitted 13 days ago • 1 comment

In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput approach to measure nuclear condensate formation, and applied it to ~14,000 IDPs to find out! rdcu.be/eq975

submitted 13 days ago • 3 comments

“The search is on for 25 researchers from around the world in Lund University’s largest ever international recruitment drive. The main focus will be on AI research and other areas in which the University has a strategic focus.” www.lunduniversity.lu.se/article/lund...

submitted 18 days ago • 0 comments

Join us in Lisbon for an International Symposium on Protein Interactions and Self-assembly Slots available for short talks and flash presentations to be selected from submitted abstracts Dates: 14-16 July WWW: twin2pipsa.campus.ciencias.ulisboa.pt/ISPIS2025.html Registration fee: 0 EUR Speakers 👇

submitted 18 days ago • 0 comments

Only a few days left to apply for our EMBO course with a great lineup of speakers and tutors! Please feel free to RT! Course website: meetings.embo.org/event/25-bio... Organizers: myself, @amjjbonvin.bsky.social @bioinfo.se @lindorfflarsen.bsky.social Location: www.ibg.edu.tr

submitted 19 days ago • 1 comment

How it started... How it's going

submitted 20 days ago • 2 comments

Why do inverse folding models work for zero-shot stability prediction? We clarify the connection to thermodynamic free energy New preprint w/ M Kassem, T Bengtsen, L Olsen, @lindorfflarsen.bsky.social, J Ferkinghoff-Borg, @wouterboomsma.bsky.social 📝 arxiv.org/abs/2506.05596 @aicentre.dk @dtu.dk

submitted 20 days ago • 0 comments

Why can one use inverse folding models to estimate changes in protein stability? @jesfrellsen.bsky.social @wouterboomsma.bsky.social et al explore this in a new preprint: Zero-shot protein stability prediction by inverse folding models: a free energy interpretation doi.org/10.48550/arX...

submitted 21 days ago • 0 comments

This paper combines two sort-of-crazy (in the best sense) approaches in cryoEM sample preparation: (1) Native, soft-landing electrospray ion beam deposition, followed by (2) deposition of amorphous ice, and reheating and freezing by laser flash melting. Has potential for time-resolved studies.

submitted 21 days ago • 0 comments

Looks useful: CGBack: Diffusion Model for Backmapping Large- Scale and Complex Coarse-Grained Molecular Systems Includes applications to reverse-CG/backmap multi-chain molecular systems, including densely packed condensates. doi.org/10.1101/2025...

submitted 21 days ago • 0 comments

Denmark — Northern Ireland Let’s go

submitted 23 days ago • 1 comment

Excited to unveil Boltz-2, our new model capable not only of predicting structures but also binding affinities! Boltz-2 is the first AI model to approach the performance of FEP simulations while being more than 1000x faster! All open-sourced under MIT license! A thread… 🤗🚀

submitted 24 days ago • 10 comments