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marcopessoa.bsky.social
Parent, husband, vinyl collector. Research Scientist at Embrapa, Brazil. Plant genomics, plant genetic resources, and breeding of tropical forages. 1st-gen DSc.
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The 'Oscar' of food prizes goes to a Brazilian who harnessed the power of bacteria Mariangela Hungria found microbes that were good at capturing nitrogen from the air and turning it into fertilizer for crops. www.npr.org/2025/05/14/n...

Genome-wide family prediction unveils molecular mechanisms underlying the regulation of agronomic traits in Urochloa ruziziensis https://www.biorxiv.org/content/10.1101/2023.09.25.559305v1

Advances in genomic characterization of Urochloa humidicola: exploring polyploid inheritance and apomixis https://www.biorxiv.org/content/10.1101/2023.08.31.555743v1

The rest of Mendel's alleles characterized! So, out of 7 traits, 3 caused by TE insertions!!! (though apparently there are two different green alleles, one cause by a TE insertion, but another a promoter deletion allele) www.nature.com/articles/s41...

Robin Waples' reference manual for the elegant, yet hideously complex concept of effective population size (Ne) #biodiversity #genomics #conservation #evolution onlinelibrary.wiley.com/doi/10.1111/...

Thrilled to see this paper out! 🎉 We analyzed 470 (!) angiosperm genomes and identified and dated 132 whole-genome duplication events. Importantly, we observed that WGD occurrence dates are not randomly distributed, but clustered at times of major environmental upheaval.

www.biorxiv.org/content/10.1...

🌱 "Introducing GWAStic: A user-friendly, cross-platform solution for genome-wide association studies and genomic prediction" integrates AI and traditional statistical methods to simplify complex genomic analyses. doi.org/10.1093/bioa... #Genomics #GWAS @snowformatics.bsky.social

🧬🖥 "new science of biological computing" #bioinformatics #classics from Aldhous P. 1993. Managing the Genome Data Deluge: Molecular biologists are turning to computer technology to help them manage the growing flood of sequencing and mapping data their field is producing. Science 262:502–503.

In a new preprint led by @TheNikhilMilind, we explored a fascinating paradox: For many traits the number of duplications or loss-of-function (LoF) mutations is correlated with phenotype. Curiously, for most traits, the AVERAGE direction of LoFs and Dups is the SAME. Why?

C. Woese was a prophet of what’s now happening in biology, namely its march to convergence and synthesis. This was simply put with a sense of destiny. Biology is realizing the value of reductionism and holism some 20 years later after this was published.

Doing good science is 90% finding a science buddy to constantly talk to about the project.

Align to AllTheBacteria with low RAM (1-2Gb) and quickly (seconds if just 1000s of hits, 15 mins for a gene present in all 2.4 million genomes) using @shenwei356.bsky.social Lexicmap. So you can basically BLAST AllTheBacteria locally - but need 3-4Tb disk for index www.biorxiv.org/content/10.1...

My work on a pangenome for the hexaploid oilseed crop Camelina sativa is now out early access in Genetics! This young polyploid genome has a small pangenome to match it's low SNP diversity, but regained lost diversity by packing in all the unique genes from its 3 diploid progenitors.

Poplar: A Phylogenetics Pipeline https://www.biorxiv.org/content/10.1101/2024.11.11.623070v1 🧬🖥️🧪 https://github.com/sandialabs/poplar

Our first draft assembly with PacBio Revio HiFi reads and hifiasm. Longest scaffold: 106 Mbp. This is a 1.5-Gbp heterozygous genome 🤯