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michaeldrazer.bsky.social
Physician-scientist @ the intersection of genomics, hematology/oncology, & patient care. Runner. Tweets are my own - no COI. Scholar: https://shorturl.at/r7pPC Lab: thedrazergroup.org
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Key rules to achieve sustainable success: 1. Consistency trumps perfection. 2. Be a minimalist to be a maximalist. 3. Have a quiet ego. 4. Focus on the process, not results. 5. Establish a secure but flexible identity. 6. Stress + Rest = Growth

Was discussing a recent case with a colleague when the utility of the day 14 marrow in our patients undergoing intensive induction for AML was discussed. Prompted a return to the "old" literature on this topic, much of which was written by Eli Estey (and @drchrishourigan.bsky.social).

Vicar of Christ

Classic lecture from Michael Joyner: "Is reductionism killing biomedical research?" youtu.be/dG8lszogw_E?... Nearly a decade on, it has aged well

1/ 🧬 A Hitchhiker’s Guide to Long-Read Genomic Analysis is out now! This mini-review walks through the latest advances in long-read DNA sequencing — from assemblies to variant calling to epigenetics. Link 🔗 genome.cshlp.org/content/35/4... 🧵👇

Probably a canary in a coal mine

Fact check: True.

From the #StemCellEvidence Alert: Factors associated with survival following allogeneic transplantation for myeloid neoplasms harboring TP53 mutations by Baranwal et al. www.stemcellevidence.com/alerts/artic... #MedSky

Happy to have had a chat about some of our recent work in inherited hematological diseases and pregnancy loss published as a CAHLN Research Pulse podcast. Team effort. @SAPathology @CCB_Research @UniversitySA @SAHealth www.buzzsprout.com/1982738/epis...

Catching up on recent presentations in the HHM space - Dr. Tawana did a superb job summarizing recent updates in the field. Worth a listen! youtu.be/XGHbvMhFtH0?...

"The Rise of Jess McClain" Fantastic video about the top American finisher on the women's side at the Boston Marathon: youtu.be/LU3vBjUdY5M?...

What do you do if you have a patient with a low Absolute Neutrophil Count (ANC)? 🤔 Follow these steps to learn how to respond appropriately 👇 Download the ASH Neutropenia Navigator to learn more: www.hematology.org/e... #DuffyNull #DANC #ASHEducation #HemeSky #MedSky @ash.edu.hematology.org

7+7 continues to show encouraging results www.nature.com/articles/s41...

Induced pluripotent stem cells are being tested to treat blindness, paralysis, Parkinson’s disease and more. Approvals might be around the corner https://go.nature.com/42xdB7d

MAP Kinase pathway strikes again

In Brief: US FDA approves the first RNAi drug for treating heart failure caused by amyloidosis. Alnylam gets the nod for #Amvuttra (vutrisiran) to treat transthyretin amyloid cardiomyopathy caused by sporadic or hereditary ATTR, expanding the drug’s label www.nature.com/articles/s41... rdcu.be/ehRIa

🧬🧪 Did you miss @ellen-epi.bsky.social talk this morning or unable to attend #KSEpigenetics25? Want a closer look at our upcoming meCUT&RUN DNA methylation sequencing and Multiomic CUT&RUN assays? 🔎 Download her poster for a sneak peek! explore.epicypher.com/posters/keys...

Absolutely loving this call-to-arms by @vigocarpathian.bsky.social in @naturebiotech.bsky.social — here it is summarized in today's Briefing

My book, An Intuitive Primer on Effective Functional Genomics Study Design, is published! I’d really appreciate it if you could help spread the word, and I’d love to hear your thoughts and feedback. I hope people will find it useful. It’s available on Amazon: tinyurl.com/mx2hewen

Keys to longevity: -Move your body regularly, sometimes hard -Eat whole foods -Lean body mass -Don't smoke -Don't drink much, if at all -Go outside -Build community -Sleep at night At this point everything else is hype. Don't "optimize" your life so much you forget to live it.

Really sharp article, although it could be further optimized for physician-scientist tracks. publichealth.realclearjournals.org/perspectives...

Two CRISPR tools for combinatorial genetic perturbations reveal gene regulatory networks #NBTNV go.nature.com/3WOWHjb rdcu.be/dItUy

SpatialRNA: a Python package for easy application of Graph Neural Network models on single-molecule spatial transcriptomics dataset www.biorxiv.org/content/10.1... 🧬🖥️🧪 github.com/pyg-team/pyt...

Many patients with rare and unexplained diseases could benefit from genome sequencing, yet access remains limited. Discover how genome sequencing works, its impact on diagnosis, and hear insights from experts Carlos Prada and Murugu Manickam. https://ja.ma/4bLt3B6

Happy Friday "Old Man" by Tom Misch - video released 5 hours ago, but it's already an instant classic. www.youtube.com/watch?v=LI8O...

Few things are more energizing and meaningful than pursuing excellence with a good team.

Laz: *chef's kiss*

Watching the US take a wrecking ball to science 💔 🤯 Reminder of the importance of doing science in the open. Put data, software, resources in public domain, where no single govt can erase them. This is our collective knowledge. Distributed data systems are essential. www.nature.com/articles/s41...