Profile avatar
ollikarkkainen.bsky.social
Senior researcher in drug toxicology at University of Eastern Finland and co-founder and CEO of Afekta Technologies Ltd. Metabolomics, biomarkers, alcohol, drugs, nutrition, disease progression, treatment responses. https://orcid.org/0000-0003-0825-4956
49 posts 767 followers 748 following
Prolific Poster

New preprint! 🚨 Itkonen et al. Metabolomic Insights: LC-MS Profiling of Human Placental Tissue from SSRI-Treated Pregnancies doi.org/10.1101/2025...

New preprint! 🚨 Itkonen et al. Metabolomic Insights: LC-MS Profiling of Human Placental Tissue from SSRI-Treated Pregnancies doi.org/10.1101/2025...

HS:n eilisessä velka-artikkelissa sivuutettiin lähes kokonaan valtionvelan hoitokustanukset ja inflaatio. Vaikka valtionvelan määrä on kasvanut, se kuormittaa julkista taloutta 2000-luvun alkua vähemmän, koska Suomi saa lainaa paljon aiempaa halvemmalla ja inflaatio pienentää lainapääoman arvoa. 1/

Its a long weekend here in Canada, which seems appropriate to mourn our recent @npp-journal.bsky.social paper, in which we find that FAAH inhibition does NOT improve symptoms in PTSD🙁 A heroic effort w/ @cannabrain.bsky.social @connorhaggarty.bsky.social @ryanntansey.bsky.social & many more 🧵⬇️

METABOLOMIC INSIGHTS: LC-MS PROFILING OF HUMAN PLACENTAL TISSUE FROM SSRI-TREATED PREGNANCIES https://www.medrxiv.org/content/10.1101/2025.05.12.25327429v1

First first author article for Eemeli Puhakka published! We identified a profile of metabolites separating those with early stage progressive alcohol-related liver disease from non-progressive alcohol-related liver disease using metabolomics doi.org/10.1111/liv.... #metabolomics #alcohol

🚨 📢 I’m #hiring!!! I am looking for an experienced #metabolomics scientist with a particular focus on LC-MS. Please follow the link below for more details and how to apply! 📢 🚨 Applications close at 23:59 on May 23rd!!! www.crick.ac.uk/careers-stud...

New publication from the Gut2Behave project! Neyrinck, Ahmed et al. Fecal transplantation from humans with obesity to mice drives a selective microbial signature without impacting behavioral and metabolic health. doi.org/10.1038/s415... #metabolomics

Important update! Thinking of submitting a poster abstract? Do not delay. Due to the high (and exciting!) volume of abstracts we will likely close abstract submission BEFORE May 15. Submit your abstract ASAP!

Metabolomics analysis reveals that tobacco smoking during pregnancy is associated with altered levels of metabolites linked to endocrine disruption and oxidative stress, and these chanses are correlated with low birth weight and small head circumference at birth. doi.org/10.1111/bcpt...

Metabolomics analysis reveals that tobacco smoking during pregnancy is associated with altered levels of metabolites linked to endocrine disruption and oxidative stress, and these chanses are correlated with low birth weight and small head circumference at birth. doi.org/10.1111/bcpt...

We have a new preprint! Here we looked at associations between levothyroxine treatment during pregnancy and metabolite and lipoprotein levels in the cord blood and in samples from the pregnant woman at different timepoints during pregnancy. www.medrxiv.org/content/10.1...

We have a new preprint! Here we looked at associations between levothyroxine treatment during pregnancy and metabolite and lipoprotein levels in the cord blood and in samples from the pregnant woman at different timepoints during pregnancy.

Alcohol: Call for new strategy targeting older people as deaths reach record high in England www.bmj.com/content/389/... via @bmj.com

Attention #Metabolomics ECRs!👩‍🔬 Meet the speakers for our upcoming Virtual Networking event w/ Metabolomics South Africa! Each bring unique insights and expertise — from academia, industry, government, and beyond Check out their bios below! 🌍 📢 #Networking #ECR Register here 🔗 tinyurl.com/9kkj85tp

Research Council of Finland preparing call for universities to invite foreign researchers to Finland

📢 Application deadline extended!! There is still time to submit your application for the ISBRA 2025 Early Career Investigator Award - application deadline has now been moved to 31st March 2025. For more details, visit: www.isbra.com/awards/early...

Today at UEF's Equality Day, Doctoral Researchers Wadzanai Masvosva and @philipchambers.bsky.social shared their experiences regarding #equality & equal opportunities at the university. Being seen & heard and inclusive communication are issues they found important.

It's time for Tox Tuesday and some fountain pen structures! This beast is BREVETOXIN-1, produced by the marine dinoflagellate Karenia brevis. It is also the cause of neurotoxic shellfish poisoning (NSP). But aside from harming humans, it also harms our economy, so buckle up!

A study using an n=1 experiment with single standards at 0V CID reported that 70% of detected ions were in-source fragments (ISFs). www.nature.com/articles/s42... This finding was extrapolated to suggest that ISFs affect all metabolomics experiments to this degree. A counterpoint. rdcu.be/ebFwc 1/n

Minna Canthin päivän iltamat 19.3 klo 17-19.00 Kuopion taidemuseolla. Keskustelua tasa-arvosta, mukana FINGO, Kuopion taidemuseo, Kuopion kaupunginteatteri, Setlementti Puijola, Minna Canthin Talo Kanttila, Martat ja UEF Tervetuloa!

Applications are open for the #FeMS+ 2025 Q2 Empowerment Awards! Thanks @brukercorporation.bsky.social for sponsoring! Apply here: airtable.com/appyGufCIumj... #TeamMAssSpec #WomenEmpowerment

Toksikologin työ yhdistää uteliaisuuden ja täsmällisen tieteen turvalliseen arkeen ja huoltovarmuuteen www.rapport.fi/juho-paavola...

New publication by Amadieu and Ahmed et al. (me included): Effect of inulin supplementation on fecal and blood metabolome in alcohol use disorder patients: A randomised, controlled dietary intervention www.sciencedirect.com/science/arti...

New Lancet Psychiatry study on 105,495 individuals with bipolar disorder in Sweden: lithium reduces the risk of hospitalisation for depression (aHR 0·75, 95% CI 0·67–0·85) mania (0·61, 0·54–0·68), and somatic hospitalisation (0·86, 0·80–0·93), unlike any other drug. doi.org/10.1016/S221...

BMJ: "instruct[ing] scientists to withdraw or retract articles from journals is sinister...We will not retract articles on the basis that they contain so-called banned words.." www.bmj.com/content/388/...

Karoliina Kurkisen väitös 13.2.2025: Aineenvaihdunnan muutoksilla yhteys nuorten mielenterveyden häiriöihin. www.uef.fi/fi/artikkeli... On ollut ilo olla toinen ohjaaja tässä kiinnostavassa väitöskirjaprojektissa!

I won't be around for ToxTueday, so you'll have to settle for ToxMonday, instead. Today, I'm posting an experiment I did about 5 years ago with my old lab for some "team building." So what did we do? Look for drugs on money, of course! What did we find? Lots, but you'll have to keep reading:

The health economics of alcohol-associated hepatitis If you are advocating for policy changes, studying the burden of AH, or evaluating the cost-effectiveness of AH interventions, this is the paper for YOU journals.lww.com/hepcomm/full... #liversky

I did a list of #WomeinSTEM working in #metabolomics & #lipidomics and #datascience please join or share with others, use it for conferences, media & networking, mentoring, supporting, anything that helps, 300+ women have joined docs.google.com/document/u/0...

🚨 Postdoc Opportunity in Chemical Exposomics in our group! Join INQUIRE project to improve indoor air quality. 🌍 Based at SciLifeLab, with guidance from Prof.Jonathan Martin and Dr. @papazianstefano.bsky.social in a dynamic research team. 📝 Apply now in www.su.se/english/abou....

🚨 New preprint with two of my favorite topics: metabolomics and post-mortem brains! We observed that high nicotine metabolite cotinine levels in frontal cortex were associated with alterations in metabolites linked to increased oxidative stress and neuroinflammation www.medrxiv.org/content/10.1...

🚨 New preprint with two of my favorite topics: metabolomics and post-mortem brains! We observed that high nicotine metabolite cotinine levels in frontal cortex were associated with alterations in metabolites linked to increased oxidative stress and neuroinflammation www.medrxiv.org/content/10.1...

🚨 New preprint! Here we did a metabolomics analysis of human post-mortem brain and CSF samples to find metabolites associated with high cotinine levels

Inulin alters fecal and blood metabolome in patients with alcohol use disorder Some interesting finding include decreased fecal levels of 5-AVAB, one of my favorite metabolites! Metabolomics paper by Amadieu, Ahmed et al. (me included): clinicalnutritionespen.com/article/S240...

🚨 New preprint! Here we did a metabolomics analysis of human post-mortem brain and CSF samples to find metabolites associated with high cotinine levels

Inulin alters fecal and blood metabolome in patients with alcohol use disorder Some interesting finding include decreased fecal levels of 5-AVAB, one of my favorite metabolites! Metabolomics paper by Amadieu, Ahmed et al. (me included): clinicalnutritionespen.com/article/S240...

Meconium metabolomics! Meconium samples from preeclamptic pregnancies have altered metabolite profiles New paper by Toivonen et al. (me included): link.springer.com/article/10.1...

Meconium metabolomics! Meconium samples from preeclamptic pregnancies have altered metabolite profiles New paper by Toivonen et al. (me included): link.springer.com/article/10.1...

Hello, Bluesky!

Anyone up for some #ToxTuesday? A lot of us love spicy foods, and the capsaicin in chili peppers that gives us that heat can be addictive. But is there anything hotter? I'm glad you asked. Yes, yes there is. And it's called RESINIFERATOXIN

Big news from Finnish publication forum. Almost all MDPI and Frontiers journals will be downgraded to level 0 and thus are not considered as properly peer reviewed trustworthy scientific journals. julkaisufoorumi.fi/en/news/chan...

New preprint 🚨 We identified metabolites (e.g. glycine conjugated bile acids and glutamate) associated with progressive alcohol-related liver disease (ALD) when compared to non-progressive ALD (simple steatosis) Excellent collaboration with Peter Stärkel's group! www.medrxiv.org/content/10.1...

Differences in the serum metabolomic profile of progressive alcohol-related liver disease in comparison to non-progressive alcohol-related liver disease: a cross sectional metabolomics study https://www.medrxiv.org/content/10.1101/2024.12.10.24318756v1

New preprint 🚨 We identified metabolites (e.g. glycine conjugated bile acids and glutamate) associated with progressive alcohol-related liver disease (ALD) when compared to non-progressive ALD (simple steatosis) Excellent collaboration with Peter Stärkel's group! www.medrxiv.org/content/10.1...

👇Check it out! 👇 Our @3d_omics project introduction video youtube.com/watch?v=Lo75... #microbiome #hologenomics #SpatialGenomics #SpatialTranscriptomics #Bioinformatics #microscopy #lasermicrodissection #nextgenseq #metabolomics

As the Editor-in-Chief I’d urge you to follow @metabolomicsj.bsky.social where you’ll get updates on the amazing #metabolomics papers we publish, as well as other news from the journal. Some exciting developments happening in 2025…

Alterations in the plasma metabolome associated with maternal smoking during the first trimester https://www.medrxiv.org/content/10.1101/2024.11.28.24318123v1

Looking for a grad position in #ecotox? Check out this opportunity!