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olzmannlab.bsky.social
Professor of Molecular Therapeutics and Metabolic Biology at UC Berkeley; Departments of Molecular & Cell Biology and Nutritional Sciences & Toxicology. Lipid droplets, ferroptosis, ubiquitin, drug development.
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So much fun catching up with my former postdoc Zhipeng Li, now an Asst Professor at U Florida. Beautiful campus and lots of cool science! πŸ‘ 🀩

What a terrific FASEB ER meeting! Exceptional science and community! ❀️ Plus we got to see sea turtles nesting on the beach and a spaceX rocket launch! Cool!

Happy to have contributed in a small way to this very cool study from Jim Wells lab, led by Fangzhu Zhao. They developed low-density lipoprotein receptor-targeting chimeras (LIPTACs) to promote induced extracellular protein degradation & ADC delivery. πŸ‘ www.biorxiv.org/content/10.1...

Happy to see our highlight out discussing new findings related to NADH and FSP1 compartmentalization in ferroptosis. Lead by two terrific postdocs Amalia Megarioti and Kirandeep Deol! 🀩 πŸ‘ www.cell.com/current-biol...

Excited to be at the FASEB ER meeting! Looking forward to a wonderful week of exciting science and to catching up with colleagues in the field. 🀩 #ERSRC

FYI - We've extended abstract submission deadline to June 8. Submit soon to be considered for a short talk. Come join us at the first FASEB #Ferroptosis meeting! It's going to be awwwwesome! 🀩 events.faseb.org/event/11797f...

Federal research cuts impact local economies, and stall progress. Publish an opinion piece in your hometown paper on June 16th to SPREAD THE WORD about how scientific research contributes to the everyday health and wealth of the general public. #McClintockLetters blogs.cornell.edu/asap/events-...

πŸ§ͺ McClintock Letters: Spread the Word! Write for your local paper Publish on June 16th

Congratulations James! From basic discovery to drugging it in such a short time! Amazing work out of #MolecularTherapeutics @mti-ucb.bsky.social @ucberkeleyofficial.bsky.social!!!

LBNL will host a new supercomputer named after @jenniferdoudna.bsky.social πŸŽ‰ newscenter.lbl.gov/2025/05/29/d...

Thrilled this paper is out! We solved the first cocrystal structure of FSP1 with an inhibitor (FSEN1), providing mechanistic insight & a foundation for medchem. Led by Amalia Megarioti & Sitao Zhang. A terrific collaboration with Da Jia. Brief Skytorial! 1/9

I always love commencement time. So much to celebrate and we get to wear our wizard robes! Congratulations to all the graduates! πŸ‘ 🀩

Congratulations to #MolecularTherapeutics faculty and @mti-ucb.bsky.social member @olzmannlab.bsky.social for receiving the Beatriz Manz award for 'transformational teaching and community service'. Glad to have you as a friend and colleague @ucberkeleyofficial.bsky.social, James!

REVIEW | KΔ±vanΓ§ Birsoy, Monther Abu-Remaileh and colleagues @rockefelleruniv.bsky.social, @stanford.edu The authors provide a broad overview of #choline #metabolism, its cellular handling, and how it impacts physiology and pathology.

Wonderful visit to the University of Oxford! What a beautiful campus. So nice to catch up with many friends there. Thanks for hosting, Pedro! 🀩

Fantastic new study from Raphael Rodriguez' lab shows that induced proximity concepts can be used to induce Ferroptosis! Inducing proximity of lysosomal iron and lipids induces lipid peroxidation! What a cool concept! Have a look at our News/Views with @olzmannlab.bsky.social shorturl.at/cbc8D

Excited to see our N&V w/ @mikelangelipid.bsky.social published in Nature, highlighting new work from Raphael Rodriguez and team. A heterofunctional molecule that activates lysosomal iron triggers lipid peroxidation and ferroptosis in therapy-resistant cancer cells. www.nature.com/articles/d41...

new out in Nature, very cool story www.nature.com/articles/s41...

Our team (hsph.harvard.edu/research/ube...) is excited to have contributed to the intranodal in vivo testing of the remarkable new compound, Fentomycin-1. Congrats to team Rodriguez et al. for the implications of this work in targeting ferroptosis in cancer. Check it out here!

Can't wait for this fantastic meeting! See you all there - registration deadline June 1. Check it out and join us there today at shorturl.at/QA6T1

Excited to be part of this meeting this summer! Great opportunity for us to learn from #ferroptosis experts. Looking forward to meeting friends/colleagues old and new.

Join for the first FASEB Ferroptosis conference in the US this July! This stellar speaker line up brings together almost all leaders in the field!

Reminder: The 1st FASEB #Ferroptosis Meeting is this summer! Spectacular speaker lineup + short talks selected from submitted abstracts. It is going to be awesome! Trainees, newcomers & all interested are welcome! πŸ“… Abstract deadline: June 1, 2025. shorturl.at/QA6T1

Excited to host @brentstockwell.bsky.social for a seminar tomorrow in the UC Berkeley Molecular Therapeutics Series! If you are on campus come by for an exceptional seminar on recent advances in our understanding and targeting of #ferroptosis! πŸ˜€

Anyone have info. into the pause on accepting Federal Payments by the University of California system due to the anti-DEI EO?

Beautiful spring day on UC Berkeley campus ☺️

I could not ask for a better group of colleagues and friends! Thank you for organizing this lovely dinner @micharapelab.bsky.social!! ☺️

tinyurl.com/mrce6bbb Fun to write this N&V together with Regina @hrshin.bsky.social, on the several cryoEM papers that build on her discovery of the fascinating LYCHOS protein and its role in cholesterol sensing and mTORC1 regulation!

Congrats to MCB faculty Liana Lareau, Edud Isacoff, Jim Hurley, Matt Welch, James Olzmann and PhD candidate Rumi Sherriff for receiving the MTI Innovator Award! πŸŽ‰πŸ‘ @olzmannlab.bsky.social, @mattwelchlab.bsky.social

Happy to have contributed in a small way to this exciting study from Daniel Nomura identifying a new covalent degrader handle that acts through the dcaf16 E3 ligase! 🀩

Excited to highlight our latest preprint by graduate student Lauren Orr on the discovery of a covalent degradative handle that acts through two unique C173 and C178, on the E3 ligase DCAF16 that can be used to modularly design monovalent and bifunctional degraders. www.biorxiv.org/content/10.1...