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rfregel.bsky.social
Associate Professor and PI of at the Paleogenomics Group at ULL (Canary Islands, Spain) working on ancient DNA of the Canary Islands human populations and more :)
23 posts 362 followers 425 following
Prolific Poster

Did leprosy exist in the Americas before European invasion? Our lab #aDNA study at @institutpasteur.bsky.social supervised by @nrascovan.bsky.social in collab with @avanzich.bsky.social (CSU) finds M.lepromatosis in pre-colonial Ancestors from North and South America www.science.org/doi/10.1126/...

🚨 Registration Deadline TONIGHT! #aDNA #HumanDNA #Research #Ethics

The FIRST International Conference on Palaeogenomics will happen in Stockholm, Sweden, June 23-26, 2026! Topics will encompass all corners of ancient DNA research, from humans to wildlife and sediments🧬🦣💀🦠 Save the dates ✅ Check the website icp2026.palaeogenomics.org and follow us for updates!

Excited to announce our paper on ancient Borrelia genomes is finally out! 🦠💀We document the evolutionary history of louse-borne relapsing fever, published today in @science.org‬ with @lucyvandorp.bsky.social and @pontus-skoglund.bsky.social #aDNA 🏺🧪🧬 Main findings and paper below: 🧵⬇️

New publication! 🎉 Here you can read all about dog drool, bleach, and a probable Central Asian Neanderthal child: doi.org/10.1016/j.ja...

www.cell.com/cell/fulltex...

It's finally out people ✅🗞️! Check out the final version of our work exploring factors influencing the germline mutation rate and spectra on ~10,000 WGS family trios 🧬👨‍👩‍👦! www.nature.com/articles/s41...

ESTO URGE Si la iniciativa ciudadana europea para prohibir las terapias de conversión en la Unión Europea no alcanza el millón de firmas antes de 5 días, por desgracia, fracasará. Más de 70 000 nuevas firmas en 24 h. Comparte, y firma aquí YA: eci.ec.europa.eu/043/public/#...

La iniciativa ciudadana para prohibir las terapias de conversión en la Unión Europea terminará en una semana y aún faltan 3000 firmas españolas para llegar a nuestro umbral. Por favor, firmad: se tarda menos de un minuto y es un tema trascendental. eci.ec.europa.eu/043/public/#...

🎉 This paper has been a long time and a labour of love (and hardship) for multiple group members, but, finally: we MPRA'ed 25k introgressed variants (Denisovan and Neanderthal) segregating at allele frequencies > 0.15 in humans today to evaluate their potential to regulate gene expression.

Cesar Fortes-Lima Fascinating talk exploring the demographic history of Sub-Saharan Africa's Bantu populations using genetic data from 14 countries. Generated datasets are vital to investigating the trans-Atlantic slave trade. www.nature.com/articles/s41... #HumanEvo25

This is finally out out: Medieval genomes from eastern Iberia illuminate the role of Morisco mass deportations in dismantling a long-standing genetic bridge with North Africa doi.org/10.1186/s130... Thread incoming...

My latest @newscientist.com cartoon

I wrote about how we must stand and fight against the threat of eugenics. Fueled by white nationalism and scientific racism, these beliefs are factually wrong and ethically abhorrent. This fight includes supporting efforts to diversify our workforce & science. To stop now would be a deep betrayal.

www.sciencedirect.com/science/arti...

I wrote a thing. I am eternally grateful for my editor, who took the original draft and helped me narrow down my key points into a more effective piece with a broader reach. Also, thanks to the editorial & legal teams, who maintained the message while protecting us in this fraught moment.

I am delighted to share with you some new insights into the selection processes that shaped the Spanish population! This work has been led by @ebosch1972.bsky.social @francesccalafell.bsky.social ( @upf.edu ) in collaboration with Rafael de Cid ( @igtp.bsky.social ) and @sabiagini.bsky.social ⬇️⬇️⬇️

Check out our ancient DNA paper on the maritime Punic civilization! 🦴🧬🌊 We find that their Levantine Phoenician cultural ancestors contributed surprisingly little ancestry to Punic sites in the central and western Mediterranean! (1/4) doi.org/10.1038/s415... #aDNA #PopGen #Punic #Phoenician

🦒🧬 New preprint🦒🧬 We investigated the degree of admixture, genetic diversity and inbreeding in ex situ giraffes using WGS data from the famous Marius, 12 zoo giraffes, and a data set from 71 wild giraffes. #ConsGen #PopGen #Genomics #Giraffes #Marius www.biorxiv.org/content/10.1...

Also out in @nature.com today, our research showing that hunter-gatherers understook substantial Mediterranean sea crossings during the Mesolithic. This research also documents the first evidence of pre-Neolithic peoples in Malta! www.nature.com/articles/s41...

New paper 🧵 A team co-led by #cpgsthlm 's researcher @jcchacond.bsky.social has analysed DNA from a large number of mammoths across a million-year timescale 🦣🧬 The findings include the discovery and analysis of the oldest known woolly #mammoth in North America! 👉 academic.oup.com/mbe/article/...

We just doubled the number of mammoth individuals with #million-year-old DNA! 🎉🦣🧬 Our new study reports 11 new #mammoth mitogenomes that are greater than 126,000 years old, of which two are more than one million years old! Congrats, Camilo (@jcchacond.bsky.social) and everyone! See thread below 👇

Ancient genomes reveal a deep history of Treponema pallidum in the Americas www.nature.com/articles/s41... #aDNA

We are happy to share our pre-print on dating bone using a novel non-destructive protocol we developed. The paper is on the Biorxiv here (Luftensteiner et al. 2025): www.biorxiv.org/content/10.1...

I'm beyond excited to share our new paper in Nature! We sequenced the first ancient human autosomal genomes from the Central Sahara, two ~7,000-year-old individuals from Takarkori in Libya, revealing a long-isolated North African lineage: www.nature.com/articles/s41... Here's a short thread: (1/n)

Our study analyzing the DNA of ~7ky-old Pastoralists from the "Green Sahara" is out! Who were these people, and how did herding spread into the region when the present-day desert was dotted with water bodies? 🧬🦴🏜️ (1/7) #PopGen #GreenSahara #aDNA www.nature.com/articles/s41...

Ancient genomes from the Green #Sahara. Study led by @nadasalem.bsky.social, @hringbauer.bsky.social & Johannes Krause reveals a long-isolated North African human lineage in the Central Sahara during the African Humid Period over 7,000 years ago. tinyurl.com/43maxc7k & www.nature.com/articles/s41...

🏺 *** IMPORTANT INFORMATION *** With thanks to the colleague who has alerted me for the lack of Alt text in this important message, please be aware of the change in format for the annual meeting #EAA2025. Information attached, and in your emails.

Repeated plague infections across six generations of Neolithic farmers #aDNA rdcu.be/eeNLE

Our paper on ancient human population structure is now published. We find that the ancestors of modern humans lived in multiple populations during the period when Homo sapiens evolved in Africa. www.nature.com/articles/s41...

How did Europe's first farmers interact with their pigs and local wild boar? @jolijnerven.bsky.social has a new paper addressing just that using 11 ancient suis genomes! www.pnas.org/doi/10.1073/...

High continuity of forager ancestry in the Neolithic period of the eastern Maghreb www.nature.com/articles/s41... #aDNA

Please enjoy part 1 of a series of blog posts written by myself and @brettfavaro.bsky.social offering our advice on how scientists can effectively speak with jouranlists about our areas of expertise. Part 2 is coming next week. Please read and share! www.southernfriedscience.com/advice-for-t... 🧪

🌍 Hello #AncientPathogens community! 🦴🧬🦠 APG's Preliminary Program is up! Registration waivers for LMIC trainees (thanks to Novogene & Twist Bioscience)! 🙌Abstract deadline extended! ⏳ 🔗 Details: liigh.unam.mx/apg/ 🇲🇽 ¡Nos vemos en Querétaro! 🌮🪅 Please RT!

This is the exciting paper drop. New aDNA science out of Dublin. Matrilineal descent systems demonstrated for Late Iron Age Dorset. Building on the work of Mel Giles (2012) who first spotted the potential for it in the archaeology of Middle Iron Age Yorkshire. www.nature.com/articles/s41...

Super excited to be at #AABA2025 this week! Our lab’s presentations and posters this year focus on aDNA, modern genomics and community engagement 🧬💀🤝 from projects in 🇵🇪 🇵🇷. All scheduled for this Saturday 🗓️ and featuring work by stellar trainees 🧑‍🔬 ! Come say hi and nerd out with us @bioanth.org 🤓

www.livescience.com/animals/dome...

Haplotype analysis of the LCT region in East Asians further complicates the story of its evolution. A 0.5Mb haplotype absent in Europeans reached frequency of 25% in East Asians. It originated in Neandertals and underwent positive selection already ~10-30kya. 1/3 www.pnas.org/doi/10.1073/...

New paper out! 📄 My first adventures in (ancient) metagenomics. 🦠 “Exploring DNA degradation in situ and in museum storage through genomics and metagenomics” www.nature.com/articles/s42... Curious about the water color painting (see ALT text)? 🦌 Thread (Bluetorial?) with findings! 🧶👇 (1/n)

Historic manioc genomes illuminate maintenance of diversity under long-lived clonal cultivation www.science.org/doi/10.1126/... #aDNA

Reassuring news for PhD students everywhere. Extracts from Crick’s lab-book 1949-50:

In @nature.com we show that humans lived in rainforests ~150,000 years ago – over double the previous oldest estimate. Their presence in West Africa’s rainforests demonstrates the spread of early humans and places ecological diversity at the heart of our species. www.nature.com/articles/s41...

🦠 1/6 Big new study alert on old animal diseases! Team analyzed 346 ancient animal bones & teeth spanning 6,000 years across Eurasia, hunting for traces of ancient pathogens. Found 68 signatures, including some nasty zoonotic diseases we still deal with today! 🤢

From reddit: a letter from a postdoc who survived the Bolsonaro years. This is helpful framing for how to science in this administration. 🧪 www.reddit.com/r/labrats/s/...

It's #DarwinDay, the year 2025. And (sad to say) this insight from the 1870s is more relevant than ever.

Finally getting some of my research for my PhD out there! Hopefully soon in a journal near you ;) Ancient Y. pestis infection from a sheep falls on the LNBA lineage, previously only known from humans! +molecular evolutionary analysis to leverage the ever increasing number of ancient genomes known!

BREAKING: 22 states sue NIH over Trump administration's new 15% cap on overhead for federal research grants. Suit filed federal court in Boston contends lifesaving research 'will grind to a halt' under the policy. Doc: storage.courtlistener.com/recap/gov.us...

Bronze Age Yersinia pestis genome from sheep sheds light on hosts and evolution of a prehistoric plague lineage https://www.biorxiv.org/content/10.1101/2025.02.07.637078v1

Study of shared segments of DNA from self-described white British and Irish groups used to reconstruct recent (last couple of hundred years) population histories of regions. Not much surprising here but interesting nonetheless! www.nature.com/articles/s41...