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rna-guy.bsky.social

Physician scientist at UW rheumatology. I study the genome to search for the causes of autoimmune diseases. Creator of a podcast (Bitesize Immunology). My research focuses on alternative splicing and non-coding RNA 🇮🇶🇺🇸 najjar.blog

56 posts 2,560 followers 585 following

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Being a scientist is like being a standup comedian, you generate jokes (data) until you have enough material for a 1-hour event, then you tour the country to perform shows (grand rounds) #academicsky

submitted 20 days ago • 0 comments

My quote of the day If an elderly but distinguished scientist says that something is possible, he is almost certainly right; but if he says that it is impossible, he is very probably wrong. Arthur C. Clarke

submitted 25 days ago • 4 comments

Reporting of the Xenon gas Mount Everest story makes it seem like anyone can just take Xenon and climb a mountain. These men were highly trained and spent 10 weeks sleeping in low oxygen tents, so they did acclimatize. It is unknown how much additional benefit Xenon provided (no control group)

submitted 24 days ago • 0 comments

First time at the #RNA25 conference. I’m delighted to overhear nearby groups say the word RNA so many times. The control frequency is zero

submitted 28 days ago • 0 comments

Phrases in immunology that mean "we do not know": - loss of tolerance - crosstalk - caused by genetic and environmental factors #ImmunoSky #MedSky

submitted 32 days ago • 0 comments

New podcast episode on inflammation. topics covered: - Inflammation is good for you - Why and how do we develop fever? I question the idea that fever boosts immune processes or hurts pathogens. - Low level non-infectious chronic inflammation #ImmunoSky #MedSky

submitted 46 days ago • 0 comments

1/2 A new publication with a new idea in autoimmunity. - The immune system learns to tolerate normally expressed peptides. This includes the multiple transcripts of the same genes that are made through alternative splicing. #MedSky #ImmunoSky #RheumSky

submitted 80 days ago • 1 comment

Weekly recap in ACR Journals Environmental Risk Factors for SLE through the Lens of Social Determinants of Health doi.org/10.1002/acr.... Dysregulated mRNA splicing in SLE doi.org/10.1002/acr2... Associations of fire smoke and other pollutants with incident RA and RA-ILD doi.org/10.1002/art....

submitted 159 days ago • 1 comment

I haven't done long exposure photography in years, decided to try it again on NYE. The space needle was electrified with fireworks and drones. Happy New Year #seattle

submitted 172 days ago • 0 comments

1/2 What do you think of these jobs I assigned to T cells? CTL= a bounty hunter with a wanted poster (TCR) Th1= a personal trainer pushing macrophages to do better Th2= a plumber flushing intestinal pipes, who also has anxiety Th17= a lobbyist asking for more neutrophils #MedSky #ImmunoSky #RheumSky

submitted 203 days ago • 1 comment

It's day 7 of your Covid-19 infection: Each T cell that recognized the virus was activated and has been copying itself over and over again until a clone army is created. Listen to my latest podcast on T cells najjar.blog/2024/12/01/what-are-t-cells/ #ImmunoSky #MedSky

submitted 204 days ago • 2 comments

1/2 A Sisyphean T cell: One of your T cells recognizes a virus that does not infect humans. It will circulate endlessly between lymph nodes, touching countless dendritic cells but never finding its antigen. Listen to my latest podcast episode on T cells najjar.blog/2024/12/01/what-are-t-cells/

submitted 206 days ago • 2 comments

Viral persistence is a complex phenomenon observed in several viruses, particularly those from the herpes family. These viruses can enter a latent state, evading detection by the innate immune system through mechanisms that aren't fully understood.

submitted 208 days ago • 3 comments

Which statement is more correct? 1. Lupus is one disease. One day we will have highly effective treatments that work for most patients 2. Lupus is a phenotypic grouping of multiple diseases. One day we will have highly effective treatments that each work for a subset of patients #medsky #rheumsky

submitted 212 days ago • 4 comments

Hi all 👋 I am new to this, but was convinced to join by @rna-guy.bsky.social for the #medsky #rheumsky of it all during #ACR2024! I am a clinician-scholar bringing a sociological structural critical lens to rheumatology especially around issues of race, gender, immigration and class. Let's connect!

submitted 219 days ago • 2 comments

I'm proud to share an original bad joke that I came up with: - What's your favorite snack? - RNA scientist: GUAC Where are my fellow RNA scientists #RNAsky #rnabiology

submitted 225 days ago • 1 comment

Added new folks to the #Immunology Starter Pack 🧪 @sarahdimeloe.bsky.social @mahimaswamy.bsky.social @profken.bsky.social @johannajoyce.bsky.social @alanmcn1.bsky.social @immunoah.bsky.social @bnmelgert.bsky.social @copperbae.bsky.social @benjaminkrishn3.bsky.social go.bsky.app/PY5tCas

submitted 241 days ago • 44 comments

A naive B cell receives a vision from an oracle (T follicular helper cell), it now knows its destiny is not to fight infection. Instead, its fate is to be auto-reactive creating an autoimmune disease (myasthenia gravis), but first it must survive the negative selection #ImmunoSky #MedSky #RheumSky

submitted 226 days ago • 2 comments

I'm working on a podcast episode on types of T cells, I try to imagine different jobs or roles for each type, to make learning more fun. I imagined the T follicular helper cell as an oracle that appears in visions to B cells to tell them their destiny #ImmunoSky #RheumSky #MedSky

submitted 228 days ago • 2 comments

Looking to gather a list of all rheumatologists and rheumatology professionals! Comment if I missed you! #ACR24 #rheum go.bsky.app/CEj2dcZ

submitted 231 days ago • 71 comments