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ruizhao.bsky.social
Synthetic biologist and protein engineer. PhD at Westlake University & Zhejiang University. Looking for postdoc positions in SynBio and protein engineering (probably starting after Sep 2025).
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Genomes encode biological complexity, which is determined by combinations of DNA mutations across millions of bases In new work @arcinstitute.org, we report the discovery and engineering of the first programmable DNA recombinases capable of megabase-scale human genome rearrangement

submitted 12 days ago • 2 comments

Far-red chemigenetic kinase biosensors enable multiplexed and super-resolved imaging of signaling networks - @michellefrei17.bsky.social @jinzhanglab.bsky.social go.nature.com/3GfqrzL

submitted 36 days ago • 1 comment

www.cell.com/cell/fulltex... ENVLPE, our system for VLP-based delivery of gene editors, is now published in @cellcellpress.bsky.social. We showed efficient delivery of base- and prime-editors in primary T cells & in vivo retinal models. All core constructs are available from @addgene.bsky.social.

submitted 47 days ago • 1 comment

LIDAR is out! rdcu.be/efugD We are one baby step closer to making it useful for therapeutics. NIH high-risk high-reward program provides key support.

submitted 60 days ago • 0 comments

So cool!

submitted 83 days ago • 0 comments

I started my lab more then 4 years ago, and we have endured some very challenging times ever since.…I am very excited to share the first paper from my lab, published now in @naturemethods.bsky.social www.nature.com/articles/s41...

submitted 96 days ago • 10 comments

Tetanus on demand! (not for bioweapons, but for neuroscience research) Tetanus toxin induces paralysis by using a protease to cleave VAMP2, a protein required for synaptic vesicle fusion and neurotransmitter release. To harness this toxicity and use it as a beneficial tool for neuroscience,

submitted 117 days ago • 2 comments

Very cool work! Thermo-controllable protein translocation.

submitted 121 days ago • 0 comments

Human-mid protease controls secreted proteins

submitted 129 days ago • 0 comments

HaloTag goes so fascinating. Nexe step?

submitted 139 days ago • 0 comments

Super excited to finally share PANCS-Binders: our group's decade-long quest to accelerate protein binder discovery. TLDR: PANCS-binders is fast (2 days), cheap (pennies), has extremely high fidelity (low false positive and negatives), and high-throughput. 1/n

submitted 140 days ago • 4 comments

I was wondering why directed evolution in mammalian cells had not yet been well developed in the last two years, and here it happens.

submitted 140 days ago • 0 comments

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..

submitted 174 days ago • 33 comments