Profile avatar
sjorsscheres.bsky.social
Joint Head of Structural Studies at @mrclmb.bsky.social. Develops & uses #cryoEM to study amyloids in neurodegeneration. #tau, #alphasynuclein, #opensoftware, #RELION. All opinions my own.
236 posts 3,214 followers 737 following
Regular Contributor
Active Commenter

Recommended!

Perhaps we could have a national discussion about personal wealth: how much money does the hardest working, smartest, most dedicated individual deserve: £10M, £100M, £1B? 🤔

This is disappointing from @theguardian.com. The study is about how social-media influences local govt decisions. Its conclusion is hopeful: social media does not seem to affect decisions too much. But the tone of discussion on social media it reports is worrying! www.theguardian.com/news/2025/ma...

The amazing Sofia Lövestam initiated the below project, when she became interested in the vault particles that we sometimes observe in #cryoEM images of brain-derived #amyloid filaments. www.biorxiv.org/content/10.1...

Congratulations to LMB Group Leaders Leo James, Greg Jefferis & Marta Zlatic who have been elected Fellows of the @royalsociety.org! Congratulations also to the #LMBAlumni joining them: John Briggs, Graham Hatfull & Baljit Khakh. Read more: www2.mrc-lmb.cam.ac.uk/leo-james-gr... #LMBNews

Whew! We’ve just recovered from that #UniversityChallenge final! Congratulations to Christ’s College for their first victory, captained by Oscar Despard, PhD student in @cellbiol-mrclmb.bsky.social. Read about the incredibly close match here: www2.mrc-lmb.cam.ac.uk/oscar-despar... #LMBNews

Labour continues the stupid culture war politics of the previous govt. 😡 Cyclists killing pedestrians is super rare. There are so many more useful things the govt could spend their time on legislating, e.g making streets safer for cyclists. www.theguardian.com/news/2025/ap...

Am having a whale of a time at the @ccpem.bsky.social Spring Symposium today! I have hung out with other crowds too recently, but it's good to be reminded how much fun Structural Biology conferences are. Atomic structure has a beautiful definitiveness to it: it is what it is. 🤗

Cool structures, Emil! 🥳

At the #Synuclein2025 in Cambridge this week. There is a large unmet need for help with #cryoEM structure determination of amyloids.

Keen to see the positive effects this will undoubtedly have on lung health in and around Paris 😍🫁🇫🇷

Great stuff by @jgreener64.bsky.social and @kjamali.bsky.social: search protein structures in 0.1 seconds using their open software!

I found the below in the stand of @stressmarq.bsky.social at #ADPD2025. When I asked how these "tau oligomers" were made, I was told this was a company secret! 😱😱😱 How can you ever publish results obtained with such materials? How could you or anyone else replicate them if the company went bust?

In Vienna for a few days for #ADPD2025. Looking forward to great scientific discussions. 😍

Finished this book today. With everything going on in the US right now, many more people should read it, especially our politicians.

Alzforum has written a piece on our most recent updates to the structure-based classification of tauopathies. 🥳 www.alzforum.org/news/researc...

🚨 PostDoc opportunity at the MRC-LMB 🚨Join our team to explore transcription-coupled splicing using cryoEM and biochemistry! 🔬🧬 Please spread the news 🙏🏼 Apply here: mrc.tal.net/vx/mobile-0/... #Postdoc #CryoEM #MolecularBiology

You can now get bitterballen in Cambridge!! 🥳🥳🥳 www.burencambridge.co.uk/menu

Having read its rather sensationalist marketing, I started reading "Doctored" by @charlespiller.bsky.social with the intention of hating it. However, I ended up appreciating this book as a much-needed reminder of the importance of doing solid science. I will encourage my trainees to read it.

The latest by me, for CityLab : How Britain’s Most Bike-Friendly New Town Is Being Built www.bloomberg.com/news/article...

Have been reading about the history of toxic oligomers of #alphasynuclein and #Abeta the past few days. As far as I can tell, this whole story originated from observations for in vitro assembly of recombinant protein, which has now been shown to yield disease-irrelevant filaments.

Just a reminder that our tenure track group leader position in the Structural Studies Division of @mrclmb.bsky.social will close in four days! mrc.tal.net/vx/lang-en-G...

Chao has shown that disease-causing tau mutations V337M and R406W both lead to the formation of filaments with the #Alzheimer fold in human brain. Could one use these mutations to speed up models for tau filament formation in AD?

Cool stuff from our collaboration with @mxhend.bsky.social: the fold of tau filaments matters for seeding in primary cultures & in live mice: the AD fold is more seeding efficient than non-AD folds! But that's not all: phosphorylation of the fuzzy coat matters too. 🤩 www.biorxiv.org/content/10.1...

If you do an experiment for someone else's paper and you become a co-author, this means that you agree with *everything* in that paper! It takes time and effort to reach consensus, but this ensures better science. That's why I cannot understand how some people publish so many papers each year.