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stimulatingbrains.org
A podcast & talk series about brain stimulation and stimulating brains. Home at the @netstim.org
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@foxmdphd.bsky.social's legendary anticorrelation paper has now been cited over 10.000 times and this was reason for a dedicated PNAS cake. Congratulations again, Mike, for this unbelievable pioneering effort that opened up the then novel field of resting-state fMRI! @braincircuits.bsky.social

Hard to keep track about all the great things our labmembers have achieved recently:

Happening today! We have two amazing speakers, Nicole Provenza and Martijn Figee who will share their thoughts on engineering for Neuromodulation and circuit based DBS for OCD respectively. Be sure to tune in on May 29th, 12 noon EST/6:00 PM CET Register here: partners.zoom.us/webinar/regi...

Are we on the cusp of moving beyond the levodopa challenge test to predict the best candidates and response to DBS in Parkinson's disease? We’ve long relied on the levodopa challenge to decide who’s a good candidate for deep brain stimulation but what if that test is only part of the story?

Is there a shared brain circuit target for tremor that transcends diagnosis and DBS site? New work by @lukasgoede.bsky.social @andreashorn.org @braincircuits.bsky.social says YES

Can brain injury cause the loss of visual imagination? We studied #aphantasia due to brain injury. Lesions were in many different regions but 100% were connected to the fusiform imagery node - a region active during visual mental imagery @braincircuits.bsky.social www.medrxiv.org/content/10.1...

Curious in an update on networks involved in treating tremor using neuromodulation? New study from the lab spearheaded by the one and only @lukasgoede.bsky.social out now at nature comms - nice summary thread below 👇👇

Tremor is a common symptom across many neurological disorders. But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis? We think: yes. Our study is out now in @natcomms.nature.com: 🔗 www.nature.com/articles/s41... 🧵 A thread.

New research from @lukasgoede.bsky.social @andreashorn.org & colleagues provides a robust, cross-condition tremor network that may guide both invasive & noninvasive neuromodulation strategies for #Parkinsons & essential tremor www.nature.com/articles/s41...

Is there a role for noninvasive "network" stimulation (multifocal tDCS) to evaluate candidates for deep brain stimulation? @lukasgoede.bsky.social says yes – new study here: onlinelibrary.wiley.com/doi/10.1002/... A 🧵 @netstim.org @braincircuits.bsky.social @lead-dbs.org

Patient selection for Deep Brain Stimulation (DBS) is crucial. Are there ways to improve it? In our new study, we found hints that non-invasive brain stimulation might enhance the levodopa response - and serve as an additional marker for DBS outcomes. doi.org/10.1002/acn3... A thread. 🧵

New insights on tremor therapeutic sweetspot and tract this time in FUS thalamotomy, congrats @andreashorn.org and team

First Fiber Filtering study using MRgFUS lesions (instead of DBS Stimulation Volumes)! 👇👇

MR guided focused ultrasound surgery is an effective and uprising treatment option for Essential tremor. But where is the optimal site to sonicate? Which spots to avoid due to side-effects? @science.org @braincircuits.bsky.social @netstim.org – a thread🧵! www.science.org/doi/10.1126/...

Mark your calendar: May 29 🧠 @nicoleprovenza.bsky.social & @mfigee.bsky.social are joining Stimulating Brains this month! Register now 👉 stimulatingbrains.org/talk-series/

When modeling volumes of tissue activated in subthalamic DBS for clinical outcomes, does it matter whether we process data in native or template space? Julianna Pijar and Clemens Neudorfer say No in the Brain Stimulation Journal: doi.org/10.1016/j.br...

It was a great honor to talk with the founding editor of Brain Stimulation, Dr. Harold Sackeim! Beyond the past, present and future of ECT, we covered the entire field of neuromodulation. Priceless insights from a key leader in the field! Tune in here 👇 stimulatingbrains.org/71-harold-sa...

Truly inspiring episode about a life lived in neurosurgery across 🇨🇦 and the 🇺🇸, from ventriculography- & frame-based procedures including ablative lesions in neuro & psych to intraoperative MRI all the way to carrying out over 600 lesions using MR guided focused ultrasound. Tune in below 👇👇

Join us on Thursday, 12 PM ET to hear more of Dr. Rees Cosgrove's thoughts on the evolution of functional neurosurgery! partners.zoom.us/webinar/regi...

We had a truly inspiring and insightful conversation with Dr. Rees Cosgrove, Director of Epilepsy and Functional Neurosurgery at @brighamandwomens.bsky.social & Professor of Neurosurgery @harvardmed.bsky.social Rediscovering the lost art of brain lesions…! stimulatingbrains.org/70-rees-cosg...

🧠 Big brains, big moves! Join us 📆 April 24 for a Stimulating Brains sesh with Dr. Rees Cosgrove & @bassamalfatly.bsky.social ⚡️ We will dive into topics of mapping causal brain networks & the evolution of movement disorder surgery! Where: partners.zoom.us/webinar/regi... 🕛 Thurs, 12 PM ET / 6 PM CET

Probably the most insightful and most important paper on physiomarkers of subthalamic DBS in a long while. Bravo @julianneumann.bsky.social @tsbinns.com and team!! Out at @natcomms.nature.com: www.nature.com/articles/s41...

Follow this interesting study led by @bahnebahners.bsky.social and @andreashorn.org using MEG‑LFP data to investigate cortico‑subthalamic coupling in Parkinson’s disease. The study showed that the optimal DBS response network defined by fMRI operates in the high‑beta band. Happy to be part of it!

Research defined the optimal DBS response network in STN-DBS for Parkinson’s Disease in a spatial domain. Other research defined physiomarkers for DBS response locally, in a temporal domain. However, nobody has analyzed these two concepts simultaneously. Enter @bahnebahners.bsky.social 👇👇

🚨 🥁 Preprint alert: The Deep Brain Stimulation Response Network in Parkinson’s Disease Operates in the High Beta Band ->> www.researchgate.net/publication/... <<--

Well have the great honor of interviewing Harold Sackeimer on the podcast soon. Any guest questions we should ask?

We had a wonderful conversation with Dr. Terry Sanger from CHOC who is a very inspirational figure and innovator in the field of DBS – with a special focus on treating pediatric forms dystonia / cerebral palsy. Tune in here 👇👇 stimulatingbrains.org/69-terrence-...

Is generalized epilepsy a seizure of the whole brain or a specific brain network? In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome. Paper: nature.com/articles/s41... A 🧵 below:

Interested in an update on connectomic and adaptive deep brain stimulation for obsessive compulsive disorder? Take a look at our summary of this exciting field and how things could be brought together out now in BPS: www.biologicalpsychiatryjournal.com/article/S000... A brief 🧵

The John #MaddoxPrize recognises researchers who stand up + speak out for science +evidence-based policy, advancing public discussion around difficult topics, despite challenges or hostility. Know someone who fits that description? Nominate them for the prize today 👉 tinyurl.com/4ma3n86t

As a long time listener and admirer of @andreashorn.org contributions to the field of neuromodulation, it was an honor and a pleasure to speak with him on @stimulatingbrains.org.

Adaptive DBS was recently approved by the FDA – in this episode, we talk with @toddherrington.bsky.social about the underlying ADAPT-PD trial, the mechanism of action of DBS, and the potential role of stem cell therapy in movement disorders. Tune in here 👇🎧👇🎧 stimulatingbrains.org/68-todd-herr...

March‘s Stimulating Brains is here! Joins us on March 27th for talks by Molly Hermiller and Ziad Nahas at noon ET/ 5 PM CET. *Please be aware that the time has changed to 5 PM CET for those in Europe.

Can an entire treatment course of TMS for depression be condensed into a single day? Find out in this very inspiring conversation with Jonathan Downar here: stimulatingbrains.org/67-jonathan-...

Ever wondered how well your Lead-DBS electrode localizations compare to expert solutions on the same data? Now, with Lead-Tutor, you can self-assess!

Want to learn DBS electrode localization with @lead-dbs.org while being able to verify your results? This new tool from the @netstim.org lab lets you compare your performance against experts. Spearheaded by Savir Madan & @laurenahart.bsky.social

Great for anyone looking to learn DBS electrode localization @braincircuits.bsky.social

Want to learn Lead-DBS yourself? This is now possible thanks to a new dataset and tool extension created by Savir Madan & @laurenahart.bsky.social – out now in @apertureohbm.bsky.social 👇👇

Very excited by this paper led by Savir Madan & @laurenahart.bsky.social, which introduces the first self-train dataset for learning Lead-DBS and a nice tool to self-assess how well localizations compare to expert solutions.

Madan and Hart et al. introduce Lead-Tutor, an open-access educational resource that combines an imaging dataset of anonymized DBS cases with a software tool for self-teaching: doi.org/10.52294/001... @laurenahart.bsky.social @andreashorn.org @jordytasserie.bsky.social @ohbmofficial.bsky.social

I am excited to announce that I will be founding an institute for network stimulation at the University Hospital Cologne – already this coming May!

Excited to introduce our database of icons for MDS-UPDRS-III items in Parkinson’s disease! Available at osf.io/ybcah/ in various formats for easy edits. We hope these icons help enhancing science communication. Big thanks to @andreashorn.org, @lukasgoede.bsky.social and the patients for their input!

Ever needed illustrations to visualize UPDRS-III exams? Well, @patriciazvarova.bsky.social just made some - free and open to use for anyone! Check them out below 👇👇

Does human creativity map to a specific brain circuit? Can damage to this brain circuit increase creativity? New paper by Julian Kutsche @isaiahneuro.bsky.social @braincircuits.bsky.social out today in JAMA Network says answer to both is YES. Paper is open access and great thread below:

How can a brain disease increase creativity? We derive a brain circuit from creative tasks demonstrating they share reduced activity in the right frontal pole. Then we show that brain lesions & neurodegeneration that increase creativity are connected to this location jamanetwork.com/journals/jam...

New center paper on lesion & atrophy mapping for creativity out in JAMA open today – great work by Julian Kutsche, @isaiahneuro.bsky.social et al.! Thread below 👇👇

Do lesions that cause psychosis fall into a common brain network? Exciting new work by @andrewpines.bsky.social, @shansiddiqi.bsky.social and colleagues – tweetorial below by the first author, paper here: jamanetwork.com/journals/jam...